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Microengineered poly(HEMA) hydrogels for wearable contact lens biosensing
, Article Lab on a Chip ; Volume 20, Issue 22 , 2020 , Pages 4205-4214 ; Zhang, S ; Cui, Q ; Ni, J ; Wang, X ; Cheng, X ; Alem, H ; Tebon, P ; Xu, C ; Guo, C ; Nasiri, R ; Moreddu, R ; Yetisen, A. K ; Ahadian, S ; Ashammakhi, N ; Emaminejad, S ; Jucaud, V ; Dokmeci, M.R ; Khademhosseini, A ; Sharif University of Technology
Royal Society of Chemistry
2020
Abstract
Microchannels in hydrogels play an essential role in enabling a smart contact lens. However, microchannels have rarely been created in commercial hydrogel contact lenses due to their sensitivity to conventional microfabrication techniques. Here, we report the fabrication of microchannels in poly(2-hydroxyethyl methacrylate) (poly(HEMA)) hydrogels that are used in commercial contact lenses with a three-dimensional (3D) printed mold. We investigated the corresponding capillary flow behaviors in these microchannels. We observed different capillary flow regimes in these microchannels, depending on their hydration level. In particular, we found that a peristaltic pressure could reinstate flow in...