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In-depth investigation of project planning and control software package application in the construction industry of iran
, Article International Journal of Engineering, Transactions A: Basics ; Volume 33, Issue 10 , 2020 , Pages 1817-1825 ; Shiri, N ; Alikhani, H ; Sharif University of Technology
Materials and Energy Research Center
2020
Abstract
Inefficient project planning and control have been identified as the main contributor to the reduced performance of the construction industry in Iran. Meanwhile, improper use of planning and control software packages (PPCSPs) in these projects can be a key factor in this reduced performance. This study investigates different aspects of the PPCSP applications to draw the role of PPCSPs in the planning and control processes of construction projects in the country using a survey-based method. It is found that only 32.5% of the construction companies in Iran highly or very highly use PPCSPs. The low level of skill and the lack of management support are two main contributing factors to this...
Chemo-mechanistic multi-scale model of a three-dimensional tumor microenvironment to quantify the chemotherapy response of cancer
, Article Biotechnology and Bioengineering ; Volume 118, Issue 10 , 2021 , Pages 3871-3887 ; 00063592 (ISSN) ; Firoozabadi, B ; Mozafari, A ; Sharif University of Technology
John Wiley and Sons Inc
2021
Abstract
Exploring efficient chemotherapy would benefit from a deeper understanding of the tumor microenvironment (TME) and its role in tumor progression. As in vivo experimental methods are unable to isolate or control individual factors of the TME, and in vitro models often cannot include all the contributing factors, some questions are best addressed with mathematical models of systems biology. In this study, we establish a multi-scale mathematical model of the TME to simulate three-dimensional tumor growth and angiogenesis and then implement the model for an array of chemotherapy approaches to elucidate the effect of TME conditions and drug scheduling on controlling tumor progression. The...