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controlled-release-formulation
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Preparation and evaluation of bioactive and compatible starch based superabsorbent for oral drug delivery systems
, Article Journal of Drug Delivery Science and Technology ; Volume 23, Issue 5 , 2013 , Pages 511-517 ; 17732247 (ISSN) ; Ebrahimi, A. A ; Barzegar, S ; Sharif University of Technology
2013
Abstract
Novel types of highly swelling hydrogels (superabsorbent) were prepared by grafting crosslinked poly acrylic acid-co-2-hydroxyethylmetacrylate (PAA-co-HEMA) chains onto starch through a free radical polymerization method. The effect of grafting variables (i.e., concentration of methylenebisacrylamide (MBA), acrylic acid/2-hydroxy methymetacrylate (AA/HEMA) weight ratio, ammonium persulfate (APS), starch, neutralization percent, were systematically optimized to achieve a hydrogel with a maximum swelling capacity. The superabsorbent (SAP) formation was confirmed by Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The controlled-release behavior of...
UV-prepared salep-based nanoporous hydrogel for controlled release of tetracycline hydrochloride in colon
, Article Journal of Photochemistry and Photobiology B: Biology ; Volume 102, Issue 3 , March , 2011 , Pages 232-240 ; 10111344 (ISSN) ; Pourjavadi, A ; Ghavami, S ; Soleyman, R ; Jafarpour, F ; Sharif University of Technology
2011
Abstract
A highly swelling nanoporous hydrogel (NPH) was synthesized via UV-irradiation graft copolymerization of acrylic acid (AA) onto salep backbone and its application as a carrier matrix for colonic delivery of tetracycline hydrochloride (TH) was investigated. Optimized synthesis of the hydrogel was performed by the classic method. The swelling behavior of optimum hydrogel was measured in different media. The hydrogel formation was confirmed by Fourier transform infrared spectroscopy (FTIR) and thermo-gravimetric analysis (TGA/DTG/DTA). The study of the surface morphology of hydrogels using SEM showed a nanoporous (average pore size: about 350 nm) structure for the sample obtained under...
Pyromellitic dianhydride crosslinked cyclodextrin nanosponges for curcumin controlled release; formulation, physicochemical characterization and cytotoxicity investigations
, Article Journal of Microencapsulation ; Volume 36, Issue 8 , 2019 , Pages 715-727 ; 02652048 (ISSN) ; Zarrabi, A ; Caldera, F ; Trotta, F ; Ghias, N ; Sharif University of Technology
Taylor and Francis Ltd
2019
Abstract
Aim: In this study, a nanosponge structure was synthesised with capability of encapsulating curcumin as a model polyphenolic compound and one of the herbal remedies that have widely been considered due to its ability to treat cancer. Methods: FTIR, DSC and XRD techniques were performed to confirm the formation of the inclusion complex of the nanosponge-drug. Results: DSC and XRD patterns showed an increasing stability and a decreasing crystallinity of curcumin after formation of inclusion complex. Encapsulation efficiency was 98% (w/w) and a significant increase was observed in loading capacity (184% w/w). The results of cytotoxicity assessments demonstrated no cell toxicity on the healthy...