Sharif Digital Repository

A thorough investigation on different controlled release systems were evaluated. The required devices were constructed simultaneously and the required experiments were performed. The polymeric network and membranes of poly vinyl alcohol with cross-linking agent glutaraldehyde for preparation of hyrogel system was effected. Paraquat, a type of herbicide was introduced as solute in the system. Glutaraldehyde was utilized as cross-linking agent at different concentration. Increase in the concentration of the cross-linking agent will cause a decrease in the extent of release out of the system. The effect of temperature on hydrogel adsorption demonstrates a higher adsorption at lower temperature.... 

Blend drug-loading method in electrospun scaffolds has gained much attention as a cost-effective and simple delivery system in regenerative medicine. However, it has some drawbacks, such as the burst release of encapsulated drugs and denaturing active agents in harsh organic solvents. In this study, a new silk fibroin-gelatin (SF–G) fibrous sheet has been introduced as an engineered scaffold and a straightforward drug delivery system for skin tissue engineering applications. The hybrid sheets have been prepared via co-electrospinning and in-situ crosslinking methods without corrosive solvents and toxic crosslinking agents. To evaluate the proposed scaffold as a controlled release system, the... 

Blend drug-loading method in electrospun scaffolds has gained much attention as a cost-effective and simple delivery system in regenerative medicine. However, it has some drawbacks, such as the burst release of encapsulated drugs and denaturing active agents in harsh organic solvents. In this study, a new silk fibroin-gelatin (SF–G) fibrous sheet has been introduced as an engineered scaffold and a straightforward drug delivery system for skin tissue engineering applications. The hybrid sheets have been prepared via co-electrospinning and in-situ crosslinking methods without corrosive solvents and toxic crosslinking agents. To evaluate the proposed scaffold as a controlled release system, the...