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    Dysregulation of lncRNAs in circulation of patients with periodontitis: results of a pilot study

    , Article BMC Oral Health ; Volume 21, Issue 1 , 2021 ; 14726831 (ISSN) Ghafouri Fard, S ; Gholami, L ; Badrlou, E ; Sadeghpour, S ; Nazer, N ; Shadnoush, M ; Sayad, A ; Taheri, M ; Sharif University of Technology
    BioMed Central Ltd  2021
    Background: Periodontitis is a chronic inflammatory disorder with a complex etiology. Long non-coding RNAs (lncRNAs) have been shown to affect pathoetiology of periodontitis. We aimed at identification of expression of five lncRNAs, namely Linc0116, Linc00667, CDK6-AS1, FENDRR and DIRC3 in the circulation and gingival tissues of these patients compared with healthy controls. Methods: In a pilot case–control study, we compared expressions of Linc0116, Linc00667, CDK6-AS1, FENDRR and DIRC3 lncRNAs between blood and tissue samples of patients with periodontitis and healthy controls using real time quantitative PCR technique. The present work was performed on samples got from 26 patients with... 

    Efficiency studies of modified IFAS-OSA system upgraded by an anoxic sludge holding tank

    , Article Scientific Reports ; Volume 11, Issue 1 , 2021 ; 20452322 (ISSN) Fazelipour, M ; Takdastan, A ; Borghei, S. M ; Kiasat, N ; Glodniok, M ; Zawartka, P ; Sharif University of Technology
    Nature Research  2021
    An upgraded integrated fixed-film activated sludge-oxic settling anoxic (IFAS-OSA) system is a new technology for reducing nutrients and excess sludge. The results showed that the average TN removal efficiency of the IFAS-OSA system was gradually increased up to 7.5%, while the PO4–3-P removal efficiency increased up-to 27%, compared with that of the IFAS system. The COD removal efficiency of the IFAS-OSA system was slightly increased up-to 5.4% and TSS removal efficiency increased up to 10.5% compared with the control system. Biomass yield coefficient (Yobs) in the IFAS and IFAS-OSA systems were 0.44 and 0.24 (gr MLSS/ gr COD). Hence, sludge production decreased by 45%. The average SVI was... 

    Two statistical methods for resolving healthy individuals and those with congestive heart failure based on extended self-similarity and a recursive method

    , Article Journal of Biological Physics ; Volume 32, Issue 6 , 2006 , Pages 489-495 ; 00920606 (ISSN) Atyabi, F ; Livari, M. A ; Kaviani, K ; Rahimi Tabar , M. R ; Sharif University of Technology
    In this paper we introduce two methods for measuring irregularities in human heartbeat time series (HHTS). First we consider the multi-fractal structure of HHTS to distinguish healthy individuals and from those with congestive heart failure. In this way we modify the Extended Self-Similarity (ESS) method and apply it to HHTS. Our second approach is based on the recursive method, which we use to predict the duration of the next heartbeat by considering a few previous ones. We use standard physiological data and show that these approaches lead to very satisfactory methods to resolve the healthy and CHF individuals. These methods can be used potentially in portable electronic heart alarm... 

    Effects of an exercise therapy targeting knee kinetics on pain, function, and gait kinetics in patients with knee osteoarthritis: A randomized clinical trial

    , Article Adapted Physical Activity Quarterly ; Volume 38, Issue 3 , 2021 , Pages 377-395 ; 07365829 (ISSN) Bokaeian, H. R ; Esfandiarpour, F ; Zahednejad, S ; Kouhzad Mohammadi, H ; Farahmand, F ; Sharif University of Technology
    Human Kinetics Publishers Inc  2021
    In this study, the effects of an exercise therapy comprising yoga exercises and medial-thrust gait (YogaMT) on lower-extremity kinetics, pain, and function in patients with medial knee osteoarthritis were investigated. Fifty-nine patients were randomly allocated to three treatment groups: (a) the YogaMT group practiced yoga exercises and medial thrust gait, (b) the knee-strengthening group performed quadriceps-and hamstring-strengthening exercises, and (c) the treadmill walking group practiced normal treadmill walking in 12 supervised sessions. The adduction and flexion moments of the hip, knee, and ankle; pain intensity; and 2-min walking test were assessed before and after treatment and at... 

    Subject-specific compressive tolerance estimates

    , Article Technology and Health Care ; Volume 11, Issue 3 , 2003 , Pages 183-193 ; 09287329 (ISSN) Davis, K. G ; Parnianpour, M ; Sharif University of Technology
    IOS Press  2003
    Spinal load models have become an increasingly valuable tool for the evaluation of the stress placed on the spine. In order to get an accurate representation of these spinal loads, they must be compared to known tolerance values. Bone mineral content and density of the lumbar spine of 23 males and 21 females was measured using a dual energy x-ray absorptiometry. Compression tolerance values were predicted by previously published studies based upon bone mineral levels. Anthropometric measurements were recorded and related to the compression tolerance values through the use of multivariate linear regression techniques. Compression tolerance values based on the bone mineral content or density... 

    The effects of anxiety and external attentional focus on postural control in patients with Parkinson’s disease

    , Article PLoS ONE ; Volume 13, Issue 2 , 2018 ; 19326203 (ISSN) Jazaeri, S. Z ; Azad, A ; Mehdizadeh, H ; Habibi, S. A ; Mandehgary Najafabadi, M ; Saberi, Z. S ; Rahimzadegan, H ; Moradi, S ; Behzadipour, S ; Parnianpour, M ; Taghizadeh, G ; Khalaf, K ; Sharif University of Technology
    Public Library of Science  2018
    Background Although anxiety is a common non-motor outcome of Parkinson's disease (PD) affecting 40% of patients, little attention has been paid so far to its effects on balance impairment and postural control. Improvement of postural control through focusing on the environment (i.e. external focus) has been reported, but the role of anxiety, as a confounding variable, remains unclear. Objectives This study aimed to investigate the influence of anxiety and attentional focus instruction on the standing postural control of PD patients. Methods Thirty-four patients with PD (17 with high anxiety (HA-PD) and 17 with low anxiety (LA-PD)), as well as 17 gender- and age-matched healthy control... 

    Optimization of operating parameters and rate of uranium bioleaching from a low-grade ore

    , Article Journal of Radioanalytical and Nuclear Chemistry ; Vol. 301, issue. 2 , 2014 , pp. 341-350 ; ISSN: 02365731 Rashidi, A ; Roosta-Azad, R ; Safdari, S. J ; Sharif University of Technology
    In this study the bioleaching of a low-grade uranium ore containing 480 ppm uranium has been reported. The studies involved extraction of uranium using Acidithiobacillus ferrooxidans derived from the uranium mine samples. The maximum specific growth rate (μ max) and doubling time (t d) were obtained 0.08 h-1 and 8.66 h, respectively. Parameters such as Fe2+ concentration, particle size, temperature and pH were optimized. The effect of pulp density (PD) was also studied. Maximum uranium bio-dissolution of 100 ± 5 % was achieved under the conditions of pH 2.0, 5 % PD and 35 °C in 48 h with the particles of d 80 = 100 μm. The optimum concentration of supplementary Fe2+ was dependent to the PD.... 

    Behavior of tilted angle shear connectors

    , Article PLoS ONE ; Volume 10, Issue 12 , December , 2015 ; 19326203 (ISSN) Khorramian, K ; Maleki, S ; Shariati, M ; Ramli Sulong, N. H ; Sharif University of Technology
    Public Library of Science  2015
    According to recent researches, angle shear connectors are appropriate to transfer longitudinal shear forces across the steel-concrete interface. Angle steel profile has been used in different positions as L-shaped or C-shaped shear connectors. The application of angle shear connectors in tilted positions is of interest in this study. This study investigates the behaviour of tilted-shaped angle shear connectors under monotonic loading using experimental push out tests. Eight push-out specimens are tested to investigate the effects of different angle parameters on the ultimate load capacity of connectors. Two different tilted angles of 112.5 and 135 degrees between the angle leg and steel... 

    Highly dispersible and magnetically recyclable poly(1-vinyl imidazole) brush coated magnetic nanoparticles: An effective support for the immobilization of palladium nanoparticles

    , Article New Journal of Chemistry ; Volume 40, Issue 2 , 2016 , Pages 1729-1736 ; 11440546 (ISSN) Pourjavadi, A ; Safaie, N ; Hosseini, S. H ; Bennett, C ; Sharif University of Technology
    Royal Society of Chemistry 
    A heterogeneous recoverable catalyst was prepared via the complexation of palladium onto the surface of magnetic nanoparticles coated by a poly(1-vinyl imidazole) brush. The stable, active and reusable catalyst was proven to be highly active in aerobic oxidation of primary and secondary alcohols with excellent yields. Only 0.1 mol% of the catalyst was used to oxidize 1 mmol of primary and secondary alcohols. The catalyst was readily recovered and reused up to 10 times under the described reaction conditions without significant loss of activity  

    The role of mscl amphipathic n terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels

    , Article Nature Communications ; Volume 7 , 2016 ; 20411723 (ISSN) Bavi, N ; Cortes, D. M ; Cox, C. D ; Rohde, P. R ; Liu, W ; Deitmer, J. W ; Bavi, O ; Strop, P ; Hill, A. P ; Rees, D ; Corry, B ; Perozo, E ; Martinac, B ; Sharif University of Technology
    Nature Publishing Group  2016
    The bacterial mechanosensitive channel MscL gates in response to membrane tension as a result of mechanical force transmitted directly to the channel from the lipid bilayer. MscL represents an excellent model system to study the basic biophysical principles of mechanosensory transduction. However, understanding of the essential structural components that transduce bilayer tension into channel gating remains incomplete. Here using multiple experimental and computational approaches, we demonstrate that the amphipathic N-terminal helix of MscL acts as a crucial structural element during tension-induced gating, both stabilizing the closed state and coupling the channel to the membrane. We... 

    MFP-Unet: A novel deep learning based approach for left ventricle segmentation in echocardiography

    , Article Physica Medica ; Volume 67 , 2019 , Pages 58-69 ; 11201797 (ISSN) Moradi, S ; GhelichOghli, M ; Alizadehasl, A ; Shiri, I ; Oveisi, N ; Oveisi, M ; Maleki, M ; Dhooge, J ; Sharif University of Technology
    Associazione Italiana di Fisica Medica  2019
    Segmentation of the Left ventricle (LV) is a crucial step for quantitative measurements such as area, volume, and ejection fraction. However, the automatic LV segmentation in 2D echocardiographic images is a challenging task due to ill-defined borders, and operator dependence issues (insufficient reproducibility). U-net, which is a well-known architecture in medical image segmentation, addressed this problem through an encoder-decoder path. Despite outstanding overall performance, U-net ignores the contribution of all semantic strengths in the segmentation procedure. In the present study, we have proposed a novel architecture to tackle this drawback. Feature maps in all levels of the decoder... 

    Trial-by-trial surprise-decoding model for visual and auditory binary oddball tasks

    , Article NeuroImage ; Volume 196 , 2019 , Pages 302-317 ; 10538119 (ISSN) Modirshanechi, A ; Kiani, M. M ; Aghajan, H ; Sharif University of Technology
    Academic Press Inc  2019
    Having to survive in a continuously changing environment has driven the human brain to actively predict the future state of its surroundings. Oddball tasks are specific types of experiments in which this nature of the human brain is studied. Detailed mathematical models have been constructed to explain the brain's perception in these tasks. These models consider a subject as an ideal observer who abstracts a hypothesis from the previous stimuli, and estimates its hyper-parameters - in order to make the next prediction. The corresponding prediction error is assumed to manifest the subjective surprise of the brain. While the approach of earlier works to this problem has been to suggest an... 

    Quantifying how staining methods bias measurements of neuron morphologies

    , Article Frontiers in Neuroinformatics ; Volume 13 , 2019 ; 16625196 (ISSN) Farhoodi, R ; Lansdell, B. J ; Kording, K. P ; Sharif University of Technology
    Frontiers Media S.A  2019
    The process through which neurons are labeled is a key methodological choice in measuring neuron morphology. However, little is known about how this choice may bias measurements. To quantify this bias we compare the extracted morphology of neurons collected from the same rodent species, experimental condition, gender distribution, age distribution, brain region and putative cell type, but obtained with 19 distinct staining methods. We found strong biases on measured features of morphology. These were largest in features related to the coverage of the dendritic tree (e.g., the total dendritic tree length). Understanding measurement biases is crucial for interpreting morphological data  

    Interview based connectivity analysis of EEG in order to detect deception

    , Article Medical Hypotheses ; Volume 136 , 2020 Daneshi Kohan, M ; Motie NasrAbadi, A ; sharifi, A ; Bagher Shamsollahi, M ; Sharif University of Technology
    Churchill Livingstone  2020
    Deception is mentioned as an expression or action which hides the truth and deception detection as a concept to uncover the truth. In this research, a connectivity analysis of Electro Encephalography study is presented regarding cognitive processes of an instructed liar/truth-teller about identity during an interview. In this survey, connectivity analysis is applied because it can provide unique information about brain activity patterns of lying and interaction among brain regions. The novelty of this paper lies in applying an open-ended questions interview protocol during EEG recording. We recruited 40 healthy participants to record EEG signal during the interview. For each subject,... 

    The effect of temperature on eccentric contraction-induced isometric force loss in isolated perfused rat medial gastrocnemius muscle

    , Article Tehran University Medical Journal ; Volume 66, Issue 6 , 2008 , Pages 388-395 ; 16831764 (ISSN) Vasaghi Gharamaleki, B ; Keshavarz, M ; Gharibzadeh, S ; Marvi, H ; Mosayebnejad, J ; Ebrahimi Takamjani, E ; Sharif University of Technology
    Tehran University of Medical Sciences  2008
    Background: The typical features of eccentric exercise-induced muscle damage are delayed-onset muscle soreness (DOMS) and prolonged loss of muscle strength. It has been shown that passive warmth is effective in reducing muscle injury. Due to the interaction of different systems in vivo, we used isolated perfused medial gastrocnemius skeletal muscle to study the direct effect of temperature on the eccentric contraction-induced force loss. Methods: After femoral artery cannulation of a rat, the left medial gastrocnemius muscle was separated and then the entire lower limb was transferred into a prewarmed (35oC) chamber. With the chamber temperature at 31, 35 and 39oC before and during eccentric... 

    Equity or equality? Which approach brings more satisfaction in a kidney-exchange chain?

    , Article Journal of Personalized Medicine ; Volume 11, Issue 12 , 2021 ; 20754426 (ISSN) Hosseinzadeh, A ; Najafi, M ; Cheungpasitporn, W ; Thongprayoon, C ; Fathi, M ; Sharif University of Technology
    MDPI  2021
    In United States (U.S.), government-funded organizations, such as NLDAC, reimburse travel and subsistence expenses incurred during living-organ donation process. However, in Iran, there is a non-governmental organization called Iranian Kidney Foundation (IKF) that funds the direct and indirect costs of donors through charitable donations and contributions from participants in the exchange program. In this article, for countries outside the U.S. that currently use an equality approach, we propose a potential new compensation-apportionment approach (equitable approach) for kidney-exchange chains and compare it with the currently available system (equality approach) in terms of the... 

    Estimation of nitrogen content in cucumber plant (Cucumis sativus L.) leaves using hyperspectral imaging data with neural network and partial least squares regressions

    , Article Chemometrics and Intelligent Laboratory Systems ; Volume 217 , 2021 ; 01697439 (ISSN) Sabzi, S ; Pourdarbani, R ; Rohban, M. H ; García Mateos, G ; Arribas, J. I ; Sharif University of Technology
    Elsevier B.V  2021
    In recent years, farmers have often mistakenly resorted to overuse of chemical fertilizers to increase crop yield. However, excessive consumption of fertilizers might lead to severe food poisoning. If nutritional deficiencies are detected early, it can help farmers to design better fertigation practices before the problem becomes unsolvable. The aim of this study is to predict the amount of nitrogen (N) content (mg l−1) in cucumber (Cucumis sativus L., var. Super Arshiya-F1) plant leaves using hyperspectral imaging (HSI) techniques and three different regression methods: a hybrid artificial neural networks-particle swarm optimization (ANN-PSO); partial least squares regression (PLSR); and... 

    The olfactory bulb modulates entorhinal cortex oscillations during spatial working memory

    , Article Journal of Physiological Sciences ; Volume 71, Issue 1 , 2021 ; 18806546 (ISSN) Salimi, M ; Tabasi, F ; Nazari, M ; Ghazvineh, S ; Salimi, A ; Jamaati, H ; Raoufy, M. R ; Sharif University of Technology
    BioMed Central Ltd  2021
    Cognitive functions such as working memory require integrated activity among different brain regions. Notably, entorhinal cortex (EC) activity is associated with the successful working memory task. Olfactory bulb (OB) oscillations are known as rhythms that modulate rhythmic activity in widespread brain regions during cognitive tasks. Since the OB is structurally connected to the EC, we hypothesized that OB could modulate EC activity during working memory performance. Herein, we explored OB–EC functional connectivity during spatial working memory performance by simultaneous recording local field potentials when rats performed a Y-maze task. Our results showed that the coherence of delta,... 

    Diagnosis of early Alzheimer's disease based on EEG source localization and a standardized realistic head model

    , Article IEEE Journal of Biomedical and Health Informatics ; Volume 17, Issue 6 , 2013 , Pages 1039-1045 ; 21682194 (ISSN) Aghajani, H ; Zahedi, E ; Jalili, M ; Keikhosravi, A ; Vahdat, B. V ; Sharif University of Technology
    In this paper, distributed electroencephalographic (EEG) sources in the brain have been mapped with the objective of early diagnosis of Alzheimer's disease (AD). To this end, records from a montage of a high-density EEG from 17 early AD patients and 17 matched healthy control subjects were considered. Subjects were in eyes-closed, resting-state condition. Cortical EEG sources were modeled by the standardized low-resolution brain electromagnetic tomography (sLORETA) method. Relative logarithmic power spectral density values were obtained in the four conventional frequency bands (alpha, beta, delta, and theta) and 12 cortical regions. Results show that in the left brain hemisphere, the theta... 

    A new framework based on recurrence quantification analysis for epileptic seizure detection

    , Article IEEE Journal of Biomedical and Health Informatics ; Volume 17, Issue 3 , 2013 , Pages 572-578 ; 21682194 (ISSN) Niknazar, M ; Mousavi, S. R ; Vosoughi Vahdat, B ; Sayyah, M ; Sharif University of Technology
    This study presents applying recurrence quantification analysis (RQA) on EEG recordings and their subbands: delta, theta, alpha, beta, and gamma for epileptic seizure detection. RQA is adopted since it does not require assumptions about stationarity, length of signal, and noise. The decomposition of the original EEG into its five constituent subbands helps better identification of the dynamical system of EEG signal. This leads to better classification of the database into three groups: Healthy subjects, epileptic subjects during a seizure-free interval (Interictal) and epileptic subjects during a seizure course (Ictal). The proposed algorithm is applied to an epileptic EEG dataset provided...