Sharif Digital Repository

Tortuosity is an abnormality that may occur in some arteries, such as carotid. It can reduce the blood flow to distal organs, and even in severe cases, causes ischemia and stroke. Tortuosity can be congenital or occurs due to hypertension and reduced axial pre-stretch of artery, in which case called buckling. Since atherosclerotic plaques disrupt the normal pattern of blood flow, and thus make the artery more susceptible to buckling, in this study, the effect of atherosclerotic plaques on arterial stability has been investigated using computational simulation of fluid-structure interaction under pulsatile flow and large deformation. Ideal geometry of normal and atherosclerotic carotid artery... 

Coronary arteries often experience tortuosity under internal blood pressure and longitude axial twisting. Arterial tortuosity can enhance the stress concentration on the artery walls. Now if the coronary arteries suffer from atherosclerosis (a common disease among adults) the stress concentration on the tortuous artery plaque will be enhanced as well. Increased stress on the plaque may result in plaque rupture and its consequent damages. This study aims to investigate the stress concentration on the plaques and blood flow patterns within the coronary arteries with plaque. Moreover, the plaque growth was predicted taking into account various geometrical parameters including fibrous cap...