Search for: curcumin
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    Photoluminescence and electrochemical investigation of curcumin-reduced graphene oxide sheets

    , Article Journal of the Iranian Chemical Society ; Volume 15, Issue 2 , February , 2018 , Pages 351-357 ; 1735207X (ISSN) Hatamie, S ; Ahadian, M. M ; Iraji zad, A ; Akhavan, O ; Jokar, E ; Sharif University of Technology
    Springer Verlag  2018
    This paper reports on a novel low-temperature method for preparing curcumin-reduced graphene oxide (Cur-rGO) from graphene oxide (GO) and investigates their cyclic voltammetry (CV) and photoluminescence (PL) properties. GO sheets were synthesized using modified Hummers’ method and then were chemically reduced using polyphenol curcumin into graphene sheets. Atomic force microscopy, transmission electron microscopy and x-ray photoelectron spectroscopy were used to confirm the formation of Cur-rGO and revealed their functionalization with polyphenol curcumin. The electrochemical and optical properties of the Cur-rGO sheets were investigated using CV and PL spectroscopy. According to the PL and... 

    The Study on Relationship between Viscoelastic Properties and Drug Release of Wound Dress Polyvinyl Alcohol Hydrogel

    , M.Sc. Thesis Sharif University of Technology Rezvan, Gelareh (Author) ; Bagheri, Reza (Supervisor) ; Pircheraghi, Gholamreza (Supervisor)
    Wound is a defect or failure in the skin texture which occurs as a result of physical or heat injuries or physiological conditions. The wound dress as a temporary cover can improve wound healing process and due to the unique properties, hydrogels have become appropriate choice for this application. Hydrogel’s structure allows drug to be loaded in the wound dress. Hydrogel wound dress should have adequate fluidity to cover wound’s bed and make full contact with the skin. Sufficient cohesion and strength is also necessary to allow the wound dress to remove from wound completely. Therefore, the study on the viscoelastic properties of hydrogel is important. In this study, polyvinyl alcohol... 

    Targeted Delivery of Curcumin by Mesoporous Silica Nanoparticle Coated with Liposome

    , M.Sc. Thesis Sharif University of Technology Hedayati, Mohammad Hassan (Author) ; Abdekhodaie, Mohammad Jafar (Supervisor) ; Akbari, Hamid (Supervisor)
    Several studies based on anti- cancer, anti- metastatic and anti- tumor effects of curcumin have been reported . Besides these benefits, the therapeutic efficacy of curcumin is limited due to its poor aqueous solubility, extensive first-pass metabolism, inadequate tissue absorption and degradation at alkaline pH, which severely diminishes its bioavailability. In this project we seek to solve some of the problems with nanoscience to work more effectively. In the past decade, mesoporous silica nanoparticles (MSNs) have found widespread application as controlled drug delivery systems. Recent reports on the design of capped and gated MSN-based systems have shown promise in preventing premature... 

    Synthesis and Characterization of Wound Dressings based on Alginate-Quince Seed Gum

    , M.Sc. Thesis Sharif University of Technology Abedini, Amir Abbas (Author) ; Pircheraghi, Gholamreza (Supervisor) ; Seyed Reihani, Morteza (Supervisor)
    Quince seed gum is a natural material that was used in Iranian traditional medicine for wound treatment. Alginate is a beneficial biomaterial that has been used in making commercial wound dressings for a long time. In this work, the preparation method and properties of films based on Alginate and Quince seed gum for drug delivery and wound healing have been investigated. According to the obtained results about crosslinking and plasticizing, the suitable condition of synthesis is 0.5% CaCl2 concentration, 2min soaking time, and 13% glycerol in crosslinking solution. In this crosslinking solution, a film with good mechanical properties (tensile strength: 13MPa, elongation: 27.3%, and Young’s... 

    Investigation on Insulin Release from Microcapsules Containing Beta Cell

    , M.Sc. Thesis Sharif University of Technology Hosseinzadeh, Zahra (Author) ; Alemzadeh, Iran (Supervisor) ; Vossoughi, Manouchehr (Supervisor)
    Type 1 diabetes, formerly known as insulin-dependent diabetes, may present at any age, but is the most common type of diabetes affecting children and adolescents. People with type 1 diabetes do not produce enough insulin. This type accounts for 5-10% of all types of diabetes. In this type of diabetes, beta cell destruction occurs in the pancreas. In type 1 diabetes, the pancreas does not secrete any insulin; insulin is a hormone that enables the body to convert glucose in food into energy. If sugar in the blood cannot enter the cells, it accumulates in the arteries and results in high blood sugar. High blood sugar over time can have irreversible effects on various parts of the body. Curcumin... 

    Curcumin as a green fluorescent label to revive the fluorescence property of functionalized graphene oxide nanosheets

    , Article Journal of Drug Delivery Science and Technology ; Volume 45 , June , 2018 , Pages 422-427 ; 17732247 (ISSN) Akbari, E ; Akhavan, O ; Hatamie, S ; Rahighi, R ; Sharif University of Technology
    Editions de Sante  2018
    In this work, graphene oxide (GO) aqueous suspensions prepared by a chemical exfoliation method showed a fluorescence peak at ∼615 nm. Photoluminescence spectroscopy determined that functionalization of the GO sheets by 3-(2-Aminoethylamino) propyltrimethoxysilane molecules significantly quench the fluorescence property of the GO sheets. Fourier transform infrared spectroscopy confirmed proper functionalization of the GO sheets. Curcumin was applied as a fluorescent natural material with an emission peak at ∼550 nm wavelength for green fluorescent labeling of the functionalized-GO sheets. The curcumin-labeled functionalized-GO sheets showed an intense emission band fluorescent property with... 

    Synthesis of Magnetic Nanocomposite Scaffolds by Electrospinning Method and Study of Drug Release Behavior

    , Ph.D. Dissertation Sharif University of Technology Khodaei, Azin (Author) ; Bagheri, Reza (Supervisor) ; Madaah Hosseini, Hamid Reza (Supervisor)
    Controlled release is a crucial factor in tissue engineering and cancer-therapy applications. The main purpose of current research is to synthesis smart magnetic nanocarriers for hydrophobic drug and embedding them in a fibrous platform for anti-cancer/ tissue engineering applications. In this regard, three different drug delivery systems of magnetic nanocolloid, magnetic fibers and hydrogels were studied. In the first phase, superparamagnetic iron oxide nanoparticles (SPIONs) were synthesized and then were modified using oleic acid and thermo-sensitive polymer of pluronic F127/F68. After characterization of this composite, Response Surface Methodology (RSM) was applied to model the lower... 

    Optimization of Insulin Releasing from Hydrogel Encapsulated Beta Cells

    , M.Sc. Thesis Sharif University of Technology Abbasi Jamaati, Parisa (Author) ; Alemzadeh, Iran (Supervisor) ; Vosoughi, Manouchehr (Co-Supervisor)
    Beta cells are responsible for secreting insulin to maintain normoglycaemia throughout the individual’s life. Type 1 Diabetes Mellitus (T1DM) is a metabolic disorder characterized by an autoimmune response that promotes the destruction of beta-cells within the pancreatic islets, resulting in lifelong inadequate insulin secretion. Encapsulating beta cells inside a semipermeable membrane to protect encapsulated cells from direct contact with the host immune system, is a new way to treat type 1 diabetes without the need for long-term immunosuppression. . In this case, the semipermeable membrane surrounds the cells and allows oxygen, nutrients, and cell products to penetrate bilaterally while... 

    Curcumin-reduced graphene oxide sheets and their effects on human breast cancer cells

    , Article Materials Science and Engineering C ; Volume 55 , 2015 , Pages 482-489 ; 09284931 (ISSN) Hatamie, S ; Akhavan, O ; Sadrnezhaad, S. K ; Ahadian, M. M ; Shirolkar, M. M ; Wang, H. Q ; Sharif University of Technology
    Elsevier Ltd  2015
    Curcumin (as a natural reductant material) was utilized for green reduction and functionalization of chemically exfoliated graphene oxide (GO) sheets. The π-π attachment of the curcumin molecules onto the curcumin-reduced graphene oxide (rGO) sheets was confirmed by Raman and Fourier transform infrared spectroscopies. Zeta potential of the GO sheets decreased from about - 40 mV to - 20 mV, after the green reduction and functionalization. The probable cytotoxicity of the curcumin-rGO sheets was studied through their interactions with two human breast cancer cell lines (MDA-MB-231 and SKBR3 cell lines) and a normal cell line (mouse fibroblast L929 cell line). The curcumin-rGO sheet with... 

    کلیدواژه های تکراریCurcumin loading potentiates the neuroprotective efficacy of Fe3O4 magnetic nanoparticles in cerebellum cells of schizophrenic rats

    , Article Biomedicine and Pharmacotherapy ; Volume 108 , 2018 , Pages 1244-1252 ; 07533322 (ISSN) Naserzadeh, P ; Ashrafi Hafez, A ; Abdorahim, M ; Abdollahifar, M. A ; Shabani, R ; Peirovi, H ; Simchi, A ; Ashtari, K ; Sharif University of Technology
    Background: The aim of this study was to investigate the neurotoxic effects of Fe3O4 magnetic- CurNPs on isolated schizophrenia mitochondria of rats as an in vivo model. Methods: We designed CMN loaded superparamagnetic iron oxide nanoparticles (SPIONs) (Fe3O4 magnetic- CurNPs) to achieve an enhanced therapeutic effect. The physicochemical properties of Fe3O4 magnetic- CurNPs were characterized using X-ray diffraction (XRD), and dynamic laser light scattering (DLS) and zeta potential. Further, to prove Fe3O4 magnetic- CurNPs results in superior therapeutic effects, and also, the mitochondrial membrane potential collapse, mitochondrial complex II activity, reactive oxygen species generation,... 

    Pyromellitic dianhydride crosslinked cyclodextrin nanosponges for curcumin controlled release; formulation, physicochemical characterization and cytotoxicity investigations

    , Article Journal of Microencapsulation ; Volume 36, Issue 8 , 2019 , Pages 715-727 ; 02652048 (ISSN) Rafati, N ; Zarrabi, A ; Caldera, F ; Trotta, F ; Ghias, N ; Sharif University of Technology
    Taylor and Francis Ltd  2019
    Aim: In this study, a nanosponge structure was synthesised with capability of encapsulating curcumin as a model polyphenolic compound and one of the herbal remedies that have widely been considered due to its ability to treat cancer. Methods: FTIR, DSC and XRD techniques were performed to confirm the formation of the inclusion complex of the nanosponge-drug. Results: DSC and XRD patterns showed an increasing stability and a decreasing crystallinity of curcumin after formation of inclusion complex. Encapsulation efficiency was 98% (w/w) and a significant increase was observed in loading capacity (184% w/w). The results of cytotoxicity assessments demonstrated no cell toxicity on the healthy... 

    Curcumin-Loaded Starch Micro/Nano particles for biomedical application: the effects of preparation parameters on release profile

    , Article Starch/Staerke ; Volume 71, Issue 5-6 , 2019 ; 00389056 (ISSN) Dehghan Baniani, D ; Zahedifar, P ; Bagheri, R ; Solouk, A ; Sharif University of Technology
    Wiley-VCH Verlag  2019
    Although curcumin is highly cytotoxic against cancer cells, its hydrophobicity and fast degradation at physiological pH limit its effective practical application. To prevent such limitations, inexpensive curcumin-loaded starch particles are synthesized in this research. Particles are prepared by water-in-oil (W/O) miniemulsion technique and an adsorption method is used for curcumin loading. Also, encapsulation efficiency (%EE) is improved by using pluronic F-127 in the drug solution. Particles are characterized, swelling studies are performed, and MTT assays against human adipose mesenchymal stem cells (hAMSCs) and MG-63 cells are utilized for investigations. Results indicate that... 

    Folic acid-functionalized niosomal nanoparticles for selective dual-drug delivery into breast cancer cells: An in-vitro investigation

    , Article Advanced Powder Technology ; Volume 31, Issue 9 , 2020 , Pages 4064-4071 Akbarzadeh, I ; Tavakkoli Yaraki, M ; Ahmadi, S ; Chiani, M ; Nourouzian, D ; Sharif University of Technology
    Elsevier B.V  2020
    In this study, a folic acid-functionalized niosome was formulated and loaded with letrozole and curcumin as a promising drug carrier system for chemotherapy of the breast cancer cells. The formulation process was optimized by varying the type of Span 80 and total lipid to drug ratio, where Span 80 and lipid to drug molar ratio of 10 resulted in the niosomes with maximum encapsulation of both drugs but minimum size. The developed niosomal formulation showed a great storage stability up to one month with the small changes in drug encapsulation efficiency and size during the storage. In addition, they showed a pH-dependent release behaviour with slow drug release at physiological pH (7.4) while... 

    Graphene oxide functionalized with oxygen-rich polymers as a pH-sensitive carrier for co-delivery of hydrophobic and hydrophilic drugs

    , Article Journal of Drug Delivery Science and Technology ; Volume 56 , 2020 Pourjavadi, A ; Asgari, S ; Hosseini, S. H ; Sharif University of Technology
    Editions de Sante  2020
    In this work, a novel carrier based-on modified graphene oxide was designed for co-delivery of hydrophobic and hydrophilic anticancer drugs (curcumin (Cur) and doxorubicin (DOX) as the model of drugs). The hydroxyl groups at the edges of graphene oxide (GO) sheets were used as the initiation sites for growing poly(epichlorohydrin) (PCH) chains. Then, hyperbranched polyglycerol (HPG) was grafted on the hydroxyl end groups of PCH (PCH-g-HPG). Pendant chlorines in the main chain of GO-PCH-g-HPG were replaced with hydrazine. The modification of GO sheets with oxygen-rich polymers increased water solubility of graphene oxide. Doxorubicin was loaded onto the nanocarrier by covalent bonding with... 

    A pilot study of the effect of phospholipid curcumin on serum metabolomic profile in patients with non-alcoholic fatty liver disease: a randomized, double-blind, placebo-controlled trial

    , Article European Journal of Clinical Nutrition ; Volume 73, Issue 9 , 2019 , Pages 1224-1235 ; 09543007 (ISSN) Chashmniam, S ; Mirhafez, S. R ; Dehabeh, M ; Hariri, M ; Azimi Nezhad, M ; Nobakht M. Gh, B. F ; Sharif University of Technology
    Nature Publishing Group  2019
    Background/Objectives: Curcumin, a natural polyphenol compound in the spice turmeric, has been found to have potent anti-oxidative and anti-inflammatory activity. Curcumin may treat non-alcoholic fatty liver disease (NAFLD) through its beneficial effects on biomarkers of oxidative stress (OS) and inflammation, which are considered as two feature of this disease. However, the effects of curcumin on NAFLD have been remained poorly understood. This investigation evaluated the effects of administrating curcumin on metabolic status in NAFLD patients. Subjects/Methods: Fifty-eight NAFLD patients participated in a randomized, double-blind, placebo-controlled parallel design of study. The subjects... 

    Involvement of TGF-β and autophagy pathways in pathogenesis of diabetes: a comprehensive review on biological and pharmacological insights

    , Article Frontiers in Pharmacology ; Volume 11 , 15 September , 2020 Heydarpour, F ; Sajadimajd, S ; Mirzarazi, E ; Haratipour, P ; Joshi, T ; Farzaei, M. H ; Khan, H ; Echeverria, J ; Sharif University of Technology
    Frontiers Media S.A  2020
    Despite recent advancements in clinical drugs, diabetes treatment still needs further progress. As such, ongoing research has attempted to determine the precise molecular mechanisms of the disorder. Specifically, evidence supports that several signaling pathways play pivotal roles in the development of diabetes. However, the exact molecular mechanisms of diabetes still need to be explored. This study examines exciting new hallmarks for the strict involvement of autophagy and TGF-β signaling pathways in the pathogenesis of diabetes and the design of novel therapeutic strategies. Dysregulated autophagy in pancreatic β cells due to hyperglycemia, oxidative stress, and inflammation is associated... 

    Burgeoning polymer nano blends for improved controlled drug release: A review

    , Article International Journal of Nanomedicine ; Volume 15 , March , 2020 , Pages 4363-4392 Maghsoudi, S ; Shahraki, B. T ; Rabiee, N ; Fatahi, Y ; Dinarvand, R ; Tavakolizadeh, M ; Ahmadi, S ; Rabiee, M ; Bagherzadeh, M ; Pourjavadi, A ; Farhadnejad, H ; Tahriri, M ; Webster, T. J ; Tayebi, L ; Sharif University of Technology
    Dove Medical Press Ltd  2020
    With continual rapid developments in the biomedical field and understanding of the important mechanisms and pharmacokinetics of biological molecules, controlled drug delivery systems (CDDSs) have been at the forefront over conventional drug delivery systems. Over the past several years, scientists have placed boundless energy and time into exploiting a wide variety of excipients, particularly diverse polymers, both natural and synthetic. More recently, the development of nano polymer blends has achieved noteworthy attention due to their amazing properties, such as biocompatibility, biodegradability and more importantly, their pivotal role in controlled and sustained drug release in vitro and... 

    Fe3O4@PAA@UiO-66-NH2 magnetic nanocomposite for selective adsorption of Quercetin

    , Article Chemosphere ; Volume 275 , 2021 ; 00456535 (ISSN) Ahmadijokani, F ; Tajahmadi, S ; Haris, M. H ; Bahi, A ; Rezakazemi, M ; Molavi, H ; Ko, F ; Arjmand, M ; Sharif University of Technology
    Elsevier Ltd  2021
    In the present study, a magnetic core-shell metal-organic framework (Fe3O4@PAA@UiO-66-NH2) nanocomposite was synthesized by a facile step-by-step self-assembly technique and used for selective adsorption of the anti-cancer Quercetin (QCT) drug. The synthesized nanocomposite was well characterized using FTIR, XRD, BET, FESEM, and TEM techniques. The adsorption kinetics and isotherms of the magnetic nanocomposites for QCT were investigated in detail at different initial concentrations and temperatures. It was found that the experimental adsorption kinetic and isotherm data were precisely explained by the pseudo-second-order kinetic and Langmuir isotherm models. Moreover, the selective... 

    Fe3O4@PAA@UiO-66-NH2 magnetic nanocomposite for selective adsorption of Quercetin

    , Article Chemosphere ; Volume 275 , 2021 ; 00456535 (ISSN) Ahmadijokani, F ; Tajahmadi, S ; Haris, M. H ; Bahi, A ; Rezakazemi, M ; Molavi, H ; Ko, F ; Arjmand, M ; Sharif University of Technology
    Elsevier Ltd  2021
    In the present study, a magnetic core-shell metal-organic framework (Fe3O4@PAA@UiO-66-NH2) nanocomposite was synthesized by a facile step-by-step self-assembly technique and used for selective adsorption of the anti-cancer Quercetin (QCT) drug. The synthesized nanocomposite was well characterized using FTIR, XRD, BET, FESEM, and TEM techniques. The adsorption kinetics and isotherms of the magnetic nanocomposites for QCT were investigated in detail at different initial concentrations and temperatures. It was found that the experimental adsorption kinetic and isotherm data were precisely explained by the pseudo-second-order kinetic and Langmuir isotherm models. Moreover, the selective... 

    Recent advances in the design and applications of amyloid-β peptide aggregation inhibitors for Alzheimer’s disease therapy

    , Article Biophysical Reviews ; Volume 11, Issue 6 , 2019 , Pages 901-925 ; 18672450 (ISSN) Jokar, S ; Khazaei, S ; Behnammanesh, H ; Shamloo, A ; Erfani, M ; Beiki, D ; Bavi, O ; Sharif University of Technology
    Springer  2019
    Alzheimer’s disease (AD) is an irreversible neurological disorder that progresses gradually and can cause severe cognitive and behavioral impairments. This disease is currently considered a social and economic incurable issue due to its complicated and multifactorial characteristics. Despite decades of extensive research, we still lack definitive AD diagnostic and effective therapeutic tools. Consequently, one of the most challenging subjects in modern medicine is the need for the development of new strategies for the treatment of AD. A large body of evidence indicates that amyloid-β (Aβ) peptide fibrillation plays a key role in the onset and progression of AD. Recent studies have reported...