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    Ultra-sensitive detection of leukemia by graphene

    , Article Nanoscale ; Vol. 6, issue. 24 , Dec , 2014 , p. 14810-14819 Akhavan, O ; Ghaderi, E ; Hashemi, E ; Rahighi, R ; Sharif Universit of Technology
    Graphene oxide nanoplatelets (GONPs) with extremely sharp edges (lateral dimensions ∼20-200 nm and thicknesses <2 nm) were applied in extraction of the overexpressed guanine synthesized in the cytoplasm of leukemia cells. The blood serums containing the extracted guanine were used in differential pulse voltammetry (DPV) with reduced graphene oxide nanowall (rGONW) electrodes to develop fast and ultra-sensitive electrochemical detection of leukemia cells at leukemia fractions (LFs) of ∼10-11 (as the lower detection limit). The stability of the DPV signals obtained by oxidation of the extracted guanine on the rGONWs was studied after 20 cycles. Without the guanine extraction, the DPV peaks...