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Submicron particle deposition in pulmonary alveoli during cyclic breathing
, Article Scientia Iranica ; Volume 24, Issue 4 , 2017 , Pages 1975-1984 ; 10263098 (ISSN) ; Saidi, M. S ; Ahmadi, G ; Sharif University of Technology
Sharif University of Technology
2017
Abstract
The prediction of deposition efficiency of submicron particles in the pulmonary alveoli has received special attention due to its importance for drug delivery systems and for assessing air pollutants health risks. In this work, the pulmonary alveoli of a healthy human are idealized by a three-dimensional honeycomb-like configuration and a fluid-structure interaction analysis is performed. In contrast to previous works in which the inlet flow rate is predefined, in this model, a negative pressure is imposed on the outside surface of the flalveolus which causes air to flow in and out of the alveolus. The resulting flow patterns confirmed that there was no circulation in the terminal alveolus....