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cytotoxic-t-lymphocyte
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Dynamics of HIV-1 Infection Models: Saturation Infection, an Eclipse Stage, CTL Immune Response
, M.Sc. Thesis Sharif University of Technology ; Hesaaraki, Mahmoud (Supervisor)
Abstract
In this thesis, three mathematical models are considered for the viral dynamics of HIV-1. The first model is an HIV infection model with saturation infection and intracellular delay, which forms a three-dimensional differential equations system, the second model includes an eclipse stage of infected cells, The viral dynamics of this model is described by four nonlinear ordinary differential equations, and finally, we study a delayed six-dimensional HIV model with CTL immune response, in fact, the main issue is the analysis of the second model (model including an eclipse stage for the infected cells).In this thesis is obtained sufficient conditions for persistence or eradication of the...
Antitumor effect of therapeutic HPV DNA vaccines with chitosan-based nanodelivery systems
, Article Journal of Biomedical Science ; Vol. 21, issue. 1 , July , 2014 ; ISSN: 10217770 ; Ghaemi, A ; Gorji, A ; Kalhor, H. R ; Sajadian, A ; Tabarraei, A ; Moradi, A ; Atyabi, F ; Kelishadi, M ; Sharif University of Technology
Abstract
Cervical cancer is the second-most-common cause of malignancies in women worldwide, and the oncogenic activity of the human papilloma virus types (HPV) E7 protein has a crucial role in anogenital tumors. In this study, we have designed a therapeutic vaccine based on chitosan nanodelivery systems to deliver HPV-16 E7 DNA vaccine, considered as a tumor specific antigen for immunotherapy of HPV-associated cervical cancer. We have developed a Nano-chitosan (NCS) as a carrier system for intramuscular administration using a recombinant DNA vaccine expressing HPV-16 E7 (NCS-DNA E7 vaccine). NCS were characterized in vitro for their gene transfection ability. Results: The transfection of CS-pEGFP...
Distinct dynamics of migratory response to pd-1 and ctla-4 blockade reveals new mechanistic insights for potential t-cell reinvigoration following immune checkpoint blockade
, Article Cells ; Volume 11, Issue 22 , 2022 ; 20734409 (ISSN) ; Goliaei, B ; Aref, A. R ; Foroughmand-Araabi, M. H ; Goliaei, S ; Lorch, J ; Jenkins, R. W ; Barbie, D. A ; Shariatpanahi, S. P ; Rüegg, C ; Sharif University of Technology
MDPI
2022
Abstract
Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death protein 1 (PD-1), two clinically relevant targets for the immunotherapy of cancer, are negative regulators of T-cell activation and migration. Optimizing the therapeutic response to CTLA-4 and PD-1 blockade calls for a more comprehensive insight into the coordinated function of these immune regulators. Mathematical modeling can be used to elucidate nonlinear tumor–immune interactions and highlight the underlying mechanisms to tackle the problem. Here, we investigated and statistically characterized the dynamics of T-cell migration as a measure of the functional response to these pathways. We used a previously...