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diabetes-mellitus--type-2
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Inhibitory activity on type 2 diabetes and hypertension key-enzymes, and antioxidant capacity of veronica persica phenolic-rich extracts
, Article Cellular and Molecular Biology ; Volume 62, Issue 6 , 2016 , Pages 80-85 ; 01455680 (ISSN) ; Tayeboon, G. S ; Sharifi Rad, J ; Iriti, M ; Varoni, E. M ; Razazi, S ; Sharif University of Technology
Cellular and Molecular Biology Association
2016
Abstract
Veronica genus (Plantaginaceae) is broadly distributed in different habitats. In this study, the inhibitory activity of free soluble and conjugated phenolic extracts of Veronica persica on key enzymes associated to type 2 diabetes (α-glucosidase and α-amylase) and hypertension (angiotensin I converting enzyme, ACE) was assessed, as well as their antioxidant power. Our results showed that both the extracts inhibited α-amylase, α-glucosidase and ACE in a dose-dependent manner. In particular, free phenolic extract significantly (P < 0.05) inhibited α-glucosidase (IC50 532.97 μg/mL), whereas conjugated phenolic extract significantly (P < 0.05) inhibited a-amylase (IC50 489.73 μg/mL) and ACE...
A perspective to the correlation between brain insulin resistance and alzheimer: medicinal chemistry approach
, Article Current Diabetes Reviews ; Volume 15, Issue 4 , 2019 , Pages 255-258 ; 15733998 (ISSN) ; Bagherzadeh, M ; Rabiee, M ; Sharif University of Technology
Bentham Science Publishers
2019
Abstract
Substantial terms have been recognized on the associated risk elements, comorbidities as well as, putative pathophysiological processes of Alzheimer disease and related dementias (ADRDs) as well as, type 2 diabetes mellitus (T2DM), a few from greatest important disease from the moments. Very much is considered regarding the biology and chemistry of each predicament, nevertheless T2DM and ADRDs are an actually similar pattern developing from the similar origins of maturing or synergistic conditions connected by aggressive patho-corporeal terms and continues to be ambiguous. In this depth-critique article, we aimed to investigate all possibilities and represented a novel and applicable...
A perspective to the correlation between brain insulin resistance and Alzheimer: Medicinal chemistry approach
, Article Current Diabetes Reviews ; Volume 15, Issue 4 , 2019 , Pages 255-258 ; 15733998 (ISSN) ; Bagherzadeh, M ; Rabiee, M ; Sharif University of Technology
Bentham Science Publishers
2019
Abstract
Substantial terms have been recognized on the associated risk elements, comorbidities as well as, putative pathophysiological processes of Alzheimer disease and related dementias (ADRDs) as well as, type 2 diabetes mellitus (T2DM), a few from greatest important disease from the moments. Very much is considered regarding the biology and chemistry of each predicament, nevertheless T2DM and ADRDs are an actually similar pattern developing from the similar origins of maturing or synergistic conditions connected by aggressive patho-corporeal terms and continues to be ambiguous. In this depth-critique article, we aimed to investigate all possibilities and represented a novel and applicable...
Association of glomerular and tubular dysfunction with glycaemic control, lipid, lipoprotein, apolipoprotein and antioxidant status in type 2 diabetes mellitus
, Article Singapore Medical Journal ; Volume 48, Issue 9 , 2007 , Pages 840-846 ; 00375675 (ISSN) ; Djalali, M ; Siassi, F ; Farvid, S. S ; Sharif University of Technology
Singapore Medical Association
2007
Abstract
Introduction: This study was conducted to investigate the relationship of glomerular and tubular dysfunctions with glycaemic control, lipid, lipoprotein, apolipoproteins and antioxidant status in 72 patients with type 2 diabetes mellitus. Methods: Urine albumin concentration was measured by immunoturbidimetric and urine N-acetyl-beta-D-glucosaminidase (NAG) and alanine aminopeptidase (AAP) activities with colorimetric methods. Glycated haemoglobin was measured using affinity chromatography. Erythrocyte glu ta thione reductase and glutathione peroxidase activities and serum levels of malondialdehyde, lipids, lipoproteins and apolipoproteins were determined in patients with type 2 diabetes...