Sharif Digital Repository

Retinal vessels tortuosity is one of the important signs of cardiovascular diseases such as diabetic retinopathy and hypertension. In this paper we present a simple and efficient algorithm to measure the grade of tortuosity in retinal images. This algorithm consists of four main steps,vessel detection, extracting vascular skeleton via thinning, detection of vessel crossovers and bifurcations and finally calculating local and global tortuosity. The last stage is based on a circular mask that is put on every skeleton point of retinal vessels. While the skeleton of vessel splits the circle in each position, the local tortuosity is considered to be the bigger to smaller area ratio. The proposed... 

Intravitreal injection (IVI) is the most common treatment for eye posterior segment diseases such as endopthalmitis, retinitis, age-related macular degeneration, diabetic retinopathy, uveitis, and retinal detachment. Most of the drugs used to treat vitreoretinal diseases, have a narrow concentration range in which they are effective, and may be toxic at higher concentrations. Therefore, it is critical to know the drug distribution within the eye following intravitreal injection. Having knowledge of drug distribution, ophthalmologists can decide on drug injection frequency while minimizing damage to tissues. The goal of this study was to develop a computer model to predict intraocular... 

The therapeutic effects of carotenoids as dietary supplements to control or even treat some specific diseases including diabetic retinopathy, cardiovascular diseases, bacterial infections, as well as breast, prostate, and skin cancer are discussed in this review and also thoughts on future research for their widespread use are emphasized. From the stability standpoint, carotenoids have low bioavailability and bioaccessibility owing to their poor water solubility, deterioration in the presence of environmental stresses such as oxygen, light, and high heat as well as rapid degradation during digestion. Nanoencapsulation technologies as wall or encapsulation materials have been increasingly...