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    Influence of formulation parameters on the release of diclofenac sodium from matrices with manufacturing formulation ingredients

    , Article Iranian Journal of Chemistry and Chemical Engineering ; Volume 21, Issue 2 , 2002 , Pages 135-140 ; 10219986 (ISSN) Abdekhodaie, M. J ; Hemmati, A. A ; Sharif University of Technology
    Effects of formulation parameters on the fractional release profile of diclofenac sodium from matrices having the manufacturing formulation ingredients are studied. As a content of cetyl alcohol (rate controlling agent) in the matrix increases, the fractional release decreases. The fractional release increases either by increasing sucrose content outside the granule or by decreasing sucrose content inside the granule. Results presented here indicate that as PVP content outside the granule or aerosil fraction inside or outside the granule in the matrix increases, the fractional release increases. The fractional release profiles of diclofenac sodium from matrices, when each ingredient is... 

    Co-Immobilization of Multi-Enzyme Cascade System into the Metal-Organic Frameworks (MOFs)for the Removal of Microcontaminants and Process Equipment Layout

    , M.Sc. Thesis Sharif University of Technology Babaei, Hassan (Author) ; Farhadi, Fatolla (Supervisor) ; Yaghmaei, Soheila (Supervisor) ; Ghobadiejad, Zahra (Co-Supervisor)
    In recent years, the biodegradation of micro-contaminants using enzymes has attracted the attention of many researchers in the field of environment and health. Micro- and nano-scale environments play an important role in enzymatic catalysis that directly affects the activity and stability of enzymes. Therefore, setting a nanoscale environment for enzymes is very important, especially in liquids with undesirable properties (such as pH, temperature, toxicity, etc.) in this work, a method proposed in which the pH and the substrate concentration are regulated for enzymatic catalysis using a metal-organic framework, consisting of Glucose Oxidase (GOx) and Horseradish Peroxidase (HRP) immobilized... 

    Preparation and evaluation of bioactive and compatible starch based superabsorbent for oral drug delivery systems

    , Article Journal of Drug Delivery Science and Technology ; Volume 23, Issue 5 , 2013 , Pages 511-517 ; 17732247 (ISSN) Pourjavadi, A ; Ebrahimi, A. A ; Barzegar, S ; Sharif University of Technology
    Novel types of highly swelling hydrogels (superabsorbent) were prepared by grafting crosslinked poly acrylic acid-co-2-hydroxyethylmetacrylate (PAA-co-HEMA) chains onto starch through a free radical polymerization method. The effect of grafting variables (i.e., concentration of methylenebisacrylamide (MBA), acrylic acid/2-hydroxy methymetacrylate (AA/HEMA) weight ratio, ammonium persulfate (APS), starch, neutralization percent, were systematically optimized to achieve a hydrogel with a maximum swelling capacity. The superabsorbent (SAP) formation was confirmed by Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The controlled-release behavior of... 

    Studying the Treatment of Pharmaceutical Waste, Using Moving Bed Biofilm Reactor

    , M.Sc. Thesis Sharif University of Technology Fatehifar, Maryam (Author) ; Borgheie, Mehdi (Supervisor)
    Pharmaceutical waste has attracted considerable attention, in the Past two decades. These pollutants had not previously been detected in the environment. In fact, the concentration of pharmaceuticals became a matter of concern after the increase in the production and consumption of drugs. Nowadays, considering their higher consumption and more developed detection technologies, they are found in waste water, treated water, rivers, etc. The purpose of this research is to study treatment of a Synthetic waste water contaminated by Diclofenac and Ibuprofen in a Moving Bed Biofilm Reactor. An aerobic Moving Bed Biofilm Reactor (MBBR) with the volume of 8.5 liters and Kaldness packing filling ratio... 

    Removal of Pharmaceuticals from Polluted Water Using Carbon Nanotube-based Membranes Coated with Enzyme

    , M.Sc. Thesis Sharif University of Technology Masjoudi, Mahsa (Author) ; Borghei, Mehdi (Supervisor) ; Ghobadi Nejad, Zahra (Co-Supervisor)
    Today, presence of micropollutants, including pharmaceutical compounds, in aquatic systems has turned into a major environmental challenge threatening the health of humans and many aquatic and terrestrial organisms. In the recent years, biodegradation of pharmaceuticals using enzymes, such as laccase, has been presented as a green method for eliminating these types of pollutants. Furthermore, regarding the improved stability and reusability of immobilized enzymes, these types of biocatalysts are suitable for industrial applications. Enzymatic membrane reactor is a promising method of enzymatic treatment and fabrication of a high-efficiency enzymatic membrane is a major step to begin this... 

    Studying Immobilization of Laccase by Entrapment and Its Applications in Micropollutants Removal from Aqueous Wastewater

    , M.Sc. Thesis Sharif University of Technology Toutounchi, Arvin (Author) ; Yaghmaei, Soheila (Supervisor) ; Ghabodinejad, Zahra (Co-Supervisor)
    One of the major environmental problems in recent years is the presence of micropollutants that cause many problems for the environment and living organisms. The micropollutant bisphenol A and the drug diclofenac are one of the pollutants and endocrine disruptors. Usually, conventional biological and physico-chemical methods do not have a high ability to remove such pollutants. Also, advanced oxidation methods usually lead to the production of highly toxic products. Using enzymes is an attractive method to remove these micropollutants. Laccase enzyme is one of the most famous enzymes in the field of biotherapy because it can remove a wider range of pollutants and it is one of the... 

    Application of moving bed biofilm reactor in the removal of pharmaceutical compounds (diclofenac and ibuprofen)

    , Article Journal of Environmental Chemical Engineering ; Volume 6, Issue 4 , 2018 , Pages 5530-5535 ; 22133437 (ISSN) Fatehifar, M ; Borghei, S. M ; Ekhlasi Nia, A ; Sharif University of Technology
    Elsevier Ltd  2018
    Pharmaceutical waste has attracted significant attention in the past two decades due to the current high consumption of pharmaceuticals together with the development of reliable detection technologies. In order to acquire better understanding on pharmaceuticals removal in biological processes, the treatment of synthetic wastewater containing diclofenac (DFN) and ibuprofen (IBU), two of the most commonly prescribed medicines worldwide, was studied using a moving bed biofilm reactor (MBBR). An 8.5-L aerobic MBBR with Kaldnes packing filling ratio of 40% was designed. The controlled parameters were pH within neutral range, temperature of 37 °C, mixed liquor suspended solids (MLSS) of 2100 mg/L,... 

    Photocatalytic Reactor Design for Elimination of Pharmaceutical Pollutants from Wastewater

    , M.Sc. Thesis Sharif University of Technology Tafrishi, Aida (Author) ; Borghei, Mehdi (Supervisor) ; Ghasemi, Shahnaz (Co-Supervisor)
    Due to the increasing number of Advanced Oxidation Processes (AOPs) that are exploited to eliminate emerging and recalcitrant contaminants from water supplies, photocatalytic degradation of Reactive Blue 21 dye using Zinc Oxide nanoparticles is investigated in both a slurry phase and an immobilized photoreactor. The structural and optical properties of the prepared ZnO nanoparticles were examined by X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM) and UV-Visible Diffuse Reflectance Spectroscopy (UV-vis DRS). The effects of photocatalyst concentration, calcination temperature, pH and UV lamps were optimized in the slurry phase photoreactor. It was shown that 250 ppm of ZnO that was... 

    Alginate-based biodegradable superabsorbents as candidates for diclofenac sodium delivery systems

    , Article Journal of Applied Polymer Science ; Volume 118, Issue 4 , 2010 , Pages 2015-2023 ; 00218995 (ISSN) Pourjavadi, A ; Zeidabadi, F ; Barzegar, Sh ; Sharif University of Technology
    Novel types of highly swelling hydrogels were prepared by grafting crosslinked polyacrylamide-co-poly-2-acrylamido-2-methylpropane sulfonic acid (PAAm-co-PAMPS) chains onto sodium alginate (Na-Alg) through a free radical polymerization method. The superabsorbent formation was confirmed by Fourier transform infrared spectroscopic (FTIR). The controlled release behavior of diclofenac sodium (DS) from superabsorbent polymer was factinvestigated, and shown that the release profiles of DS from superabsorbent polymer were slow in simulated gastric fluid (SGF, pH 1.2) over 3 h, but nearly all of the initial drug content was released in simulated intestinal fluid (SIF, pH 7.4) within 21 h after... 

    Facilitation of transscleral drug delivery by drug loaded magnetic polymeric particles

    , Article Materials Science and Engineering C ; Volume 79 , 2017 , Pages 812-820 ; 09284931 (ISSN) Mousavikhamene, Z ; Abdekhodaie, M. J ; Ahmadieh, H ; Sharif University of Technology
    A unique method was used to facilitate ocular drug delivery from periocular route by drug loaded magnetic sensitive particles. Injection of particles in periocular space along the eye axis followed by application of magnetic field in front of the eye would trigger the magnetic polymeric particles to move along the direction of magnetic force and reside against the outer surface of the sclera. This technique prevents removal of drug in the periocular space, observed in conventional transscleral drug delivery systems and hence higher amount of drug can enter the eye in a longer period of time. The experiments were performed by fresh human sclera and an experimental setup. Experimental setup... 

    Second-order calibration for simultaneous determination of pharmaceuticals in water samples by solid-phase extraction and fast high-performance liquid chromatography with diode array detector

    , Article Chemometrics and Intelligent Laboratory Systems ; Vol. 137, issue , 2014 , pp. 146-154 ; ISSN: 01697439 Akvan, N ; Parastar, H ; Sharif University of Technology
    A fast high-performance liquid chromatography-diode array detection (HPLC-DAD) approach combined to solid phase extraction (SPE) as a pre-concentration step is developed for simultaneous determination of five selected pharmaceuticals (carbamazepine, naproxen, diclofenac, gemfibrozil and mefenamic acid) in water samples. The effective factors on the efficiency of SPE procedure are optimized using faced-centered central composite design (FCCD). In addition, multi-response optimization by using Derringer's desirability function is used to find the optimum experimental conditions for extraction of analytes from well and river waters. Due to the complexity of water matrices and the presence of... 

    Porous eco–friendly fibers for on–line micro solid–phase extraction of nonsteroidal anti–inflammatory drugs from urine and plasma samples

    , Article Journal of Chromatography A ; Volume 1574 , 2018 , Pages 18-26 ; 00219673 (ISSN) Golzari Aqda, T ; Behkami, S ; Bagheri, H ; Sharif University of Technology
    Elsevier B.V  2018
    In this study, cellulose acetate (CA) fibers were prepared using different solvent systems in electrospinning. The recorded scanning electron microscopy micrographs indicated that the morphology of the prepared fibers is closely associated with the type of electrospinning solvents. The prepared CA fibers were used as an extractive phase for on–line micro–solid phase extraction (μ-SPE) of nonsteroidal–inflammatory drugs (NSAIDs) in biological samples pursued by HPLC–UV determination. Work conducted on this research ascertained that the use of dichloromethane:acetone (3:1, v/v) solvent system in the CA dissolution for electrospinning, leads to the formation of porous ribbon–like fibers and... 

    Amine modified magnetic polystyrene for extraction of drugs from urine samples

    , Article Journal of Chromatography A ; Volume 1602 , 2019 , Pages 107-116 ; 00219673 (ISSN) Zeinali, S ; Maleki, M ; Bagheri, H ; Sharif University of Technology
    Elsevier B.V  2019
    Polystyrene is one of the best candidates as the extracting medium due to its high stability in different media and acceptable extraction capability. However, the hydrophobic nature and low wettability of polystyrene limits its application to non–polar analytes. To resolve this limitation, in this project, amine groups were chemically attached to the surface of magnetic polystyrene. The resulting hydrophilic magnetic particles were expected to be capable of extracting both polar and non–polar analytes. Non–steroidal anti–inflammatory drugs (NSAIDs) were chosen for testing the applicability of modified magnetic polystyrene according to the importance of their analysis and also their wide... 

    Pharmaceuticals removal by immobilized laccase on polyvinylidene fluoride nanocomposite with multi-walled carbon nanotubes

    , Article Chemosphere ; Volume 263 , 2021 ; 00456535 (ISSN) Masjoudi, M ; Golgoli, M ; Ghobadi Nejad, Z ; Sadeghzadeh, S ; Borghei, S. M ; Sharif University of Technology
    Elsevier Ltd  2021
    The presence of pharmaceutical micropollutants in water and wastewater is considered a serious environmental issue. To eliminate these pollutants, biodegradation of pharmaceuticals using enzymes such as laccase, is proposed as a green method. In this study, immobilized laccase was used for the removal of two model pharmaceutical compounds, carbamazepine and diclofenac. Polyvinylidene fluoride (PVDF) membrane modified with multi-walled carbon nanotubes (MWCNTs) were synthesized as a tailor-made support for enzyme immobilization. Covalently immobilized laccase from Trametes hirsuta exhibited remarkable activity and activity recovery of 4.47 U/cm2 and 38.31%, respectively. The results also...