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diethyl--phenylamino---4-tolyl-methyl-phosphonate
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An efficient one-pot synthesis of 1-aminophosphonates
, Article Synthesis (Germany) ; Volume 55, Issue 1 , Volume 55, Issue 1 , 2022 , Pages 121-130 ; 00397881 (ISSN) ; Faghih, S ; Alavi, S ; Naimi Jamal, M. R ; Fattahi, A ; Sharif University of Technology
Georg Thieme Verlag
2022
Abstract
1-Aminophosphonates are valuable compounds with wide range of applications in biological and industry. Various reaction conditions and catalysts have been reported for the synthesis of 1-aminophosphonates via three-component (dialkyl phosphite + aldehyde + amine) or two-component reaction (dialkyl phosphite + imine). Here a solvent-free synthesis of 1-aminophosphonates under very mild reaction conditions is reported. The three-component condensation reactions of dialkyl phosphite, carbonyl compound, and an amine gave 1- aminophosphonates in good to excellent yields under solvent- and catalyst-free conditions at ambient temperature. Hydrophosphorylation of imines in the presence of dialkyl...