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dimethyl-4--cyclohexylamino--6-methylquinoline-2-3-dicarboxylate
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Novel one-pot synthesis of functionalized quinolines from isocyanides, aniline, and acetylene dicarboxylate via cu-catalyzed intramolecular C─H activation reactions
, Article Journal of Heterocyclic Chemistry ; Volume 56, Issue 4 , 2019 , Pages 1254-1259 ; 0022152X (ISSN) ; Rezaee, E ; Jahani, M ; Tabatabai, S. A ; Sharif University of Technology
HeteroCorporation
2019
Abstract
The one-pot synthesis of a novel class of substituted quinoline derivatives with good yields is achieved via the Cu-catalyzed intramolecular C─H activation reaction between isocyanides, aniline, and acetylene dicarboxylate in MeCN at room temperature. The existence of one-pot conditions, availability of a starting material-catalyst, the absence of column chromatography, and a high yield of products are among the advantages of this method. The structures are confirmed spectroscopically (1H NMR and 13C NMR, IR, and EI-MS) and through elemental analyses