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    Inhibition mechanisms of a pyridazine-based amyloid inhibitor: as a β-sheet destabilizer and a helix bridge maker

    , Article Journal of Physical Chemistry B ; Volume 121, Issue 32 , 2017 , Pages 7633-7645 ; 15206106 (ISSN) Kalhor, H. R ; Jabbari, M. P ; Sharif University of Technology
    Abstract
    Conformational diseases have been investigated extensively in recent years; as a result, a number of drug candidates have been introduced as amyloid inhibitors; however, no effective therapies have been put forward. RS-0406 with pyridazine as its core chemical structure has so far shown promising results in inhibiting amyloid formation. In the present work, using molecular dynamics, we undertook the investigation of RS-0406 interactions with U-shaped Aβ1−42 and Aβ1−40 pentamers, Aβ1−42 monomers, and double-horseshoe-like Aβ1−42. To set better parameters for the small molecule, experimental and computational log P values were obtained. In addition, an analogue of RS-0406 was also simulated... 

    Adaptive control strategy for treatment of hepatitis C infection

    , Article Industrial and Engineering Chemistry Research ; Volume 58, Issue 33 , 2019 , Pages 15262-15270 ; 08885885 (ISSN) Zeinali, S ; Shahrokhi, M ; Sharif University of Technology
    American Chemical Society  2019
    Abstract
    In this work, an efficient treatment strategy for hepatitis C disease using interferon (IFN) has been proposed on the basis of the back-stepping control technique. The basic model of the hepatitis C virus (HCV) has been considered for controller design. To tackle the problem of model parameter variations, the adaptive version of the back-stepping method has been utilized. For applying the proposed treatment, all states should be available while only the viral load is measured. To solve this problem, a nonlinear Luenberger-like observer has been designed to estimate the unmeasured states. In the proposed treatment, limitation of the drug efficacy has been taken into account. Asymptotical... 

    Parallel nonlinear analysis of weighted brain's gray and white matter images for Alzheimer's dementia diagnosis

    , Article 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10, 31 August 2010 through 4 September 2010, Buenos Aires ; 2010 , Pages 5573-5576 ; 9781424441235 (ISBN) Razavian, S. M. J ; Torabi, M ; Kim, K ; Sharif University of Technology
    2010
    Abstract
    In this study, we are proposing a novel nonlinear classification approach to discriminate between Alzheimer's Disease (AD) and a control group using T1-weighted and T2- weighted Magnetic Resonance Images (MRI's) of brain. Since T1-weighted images and T2-weighted images have inherent physical differences, obviously each of them has its own particular medical data and hence, we extracted some specific features from each. Then the variations of the relevant eigenvalues of the extracted features were tracked to pick up the most informative ones. The final features were assigned to two parallel systems to be nonlinearly categorized. Considering the fact that AD defects the white and gray regions... 

    The Differential Diagnosis of Crohn's Disease and Celiac Disease Using Nuclear Magnetic Resonance Spectroscopy

    , Article Applied Magnetic Resonance ; Volume 45, Issue 5 , May , 2014 , Pages 451-459 Fathi, F ; Kasmaee, L. M ; Sohrabzadeh, K ; Nejad, M. R ; Tafazzoli, M ; Oskouie, A. A ; Sharif University of Technology
    Abstract
    Crohn's disease and celiac disease belong to a group of autoimmune conditions that affect the digestive system, specifically the small intestine. They both attack the digestive tract and share many symptoms. Thus, the discovery of proper methods would be a major step toward differentiating celiac disease from Crohn's disease. The aim of this study was to search for the metabolic biomarkers to differentiate between these two diseases. Proton nuclear magnetic resonance spectroscopy (1H NMR) was employed as the metabolic profiling method to look for serum metabolites that differentiate between celiac disease and Crohn's disease. Classification of celiac disease and Crohn's disease was done... 

    Graphene scaffolds in progressive nanotechnology/stem cell-based tissue engineering of the nervous system

    , Article Journal of Materials Chemistry B ; Volume 4, Issue 19 , 2016 , Pages 3169-3190 ; 20507518 (ISSN) Akhavan, O ; Sharif University of Technology
    Royal Society of Chemistry  2016
    Abstract
    Although graphene/stem cell-based tissue engineering has recently emerged and has promisingly and progressively been utilized for developing one of the most effective regenerative nanomedicines, it suffers from low differentiation efficiency, low hybridization after transplantation and lack of appropriate scaffolds required in implantations without any degrading in functionality of the cells. In fact, recent studies have demonstrated that the unique properties of graphene can successfully resolve all of these challenges. Among various stem cells, neural stem cells (NSCs) and their neural differentiation on graphene have attracted a lot of interest, because graphene-based neuronal tissue... 

    Nonlinear robust adaptive sliding mode control of influenza epidemic in the presence of uncertainty

    , Article Journal of Process Control ; Volume 56 , 2017 , Pages 48-57 ; 09591524 (ISSN) Sharifi, M ; Moradi, H ; Sharif University of Technology
    Elsevier Ltd  2017
    Abstract
    In this paper, a nonlinear robust adaptive sliding mode control strategy is presented for the influenza epidemics in the presence of model uncertainties. The nonlinear epidemiological model of influenza with five state variables (the numbers of susceptible, exposed, infected, asymptomatic and recovered individuals) and two control inputs (vaccination and antiviral treatment) is considered. The objective of the proposed controller is decreasing the number of susceptible and infected humans to zero by tracking the desired scenarios. As a result of this decreasing, the number of exposed and asymptomatic individuals is also decreased and converged to the zero. Accordingly, it is shown that the... 

    Development of a sensitive diagnostic device based on zeolitic imidazolate frameworks-8 using ferrocene-graphene oxide as electroactive indicator for pseudomonas aeruginosa detection

    , Article ACS Sustainable Chemistry and Engineering ; Volume 7, Issue 15 , 2019 , Pages 12760-12769 ; 21680485 (ISSN) Shahrokhian, S ; Ranjbar, S ; Sharif University of Technology
    American Chemical Society  2019
    Abstract
    Since Gram-negative bacteria have a predominant role in nosocomial infections, there are high demands to develop a fast and sensitive method for diagnosis of bacteria in clinical samples. To address this challenge, we designed a novel electrochemical biosensor based on aptamers immobilized in engineered zeolitic imidazolate Framework-8 (ZIFs-8) via EDC-NHS chemistry. Cyclic voltammetry and electrochemical impedance spectroscopy techniques were conducted to monitor the electrochemical characterization. With respect to unique π-πinteractions between aptamer and graphene oxide (GO), the differential pulse voltammetry technique was applied with ferrocene-graphene oxide (Fc-GO) as an... 

    Centrality-based epidemic control in complex social networks

    , Article Social Network Analysis and Mining ; Volume 10, Issue 1 , 2020 Doostmohammadian, M ; Rabiee, H. R ; Khan, U. A ; Sharif University of Technology
    Springer  2020
    Abstract
    Recent progress in the areas of network science and control has shown a significant promise in understanding and analyzing epidemic processes. A well-known model to study epidemics processes used by both control and epidemiological research communities is the susceptible–infected–susceptible (SIS) dynamics to model the spread of disease/viruses over contact networks of infected and susceptible individuals. The SIS model has two metastable equilibria: one is called the endemic equilibrium and the other is known as the disease-free or healthy-state equilibrium. Control theory provides the tools to design control actions (allocating curing or vaccination resources) in order to achieve and... 

    How do the smart travel ban policy and intercity travel pattern affect COVID-19 trends? Lessons learned from Iran

    , Article PLoS ONE ; Volume 17, Issue 10 October , 2022 ; 19326203 (ISSN) Nassiri, H ; Mohammadpour, S. I ; Dahaghin, M ; Sharif University of Technology
    Public Library of Science  2022
    Abstract
    COVID-19, as the most significant epidemic of the century, infected 467 million people and took the lives of more than 6 million individuals as of March 19, 2022. Due to the rapid transmission of the disease and the lack of definitive treatment, countries have employed non-pharmaceutical interventions. This study aimed to investigate the effectiveness of the smart travel ban policy, which has been implemented for non-commercial vehicles in the intercity highways of Iran since November 21, 2020. The other goal was to suggest efficient COVID-19 forecasting tools and to examine the association of intercity travel patterns and COVID-19 trends in Iran. To this end, weekly confirmed cases and... 

    Nanomaterials for photothermal and photodynamic cancer therapy

    , Article Applied Physics Reviews ; Volume 9, Issue 1 , 2022 ; 19319401 (ISSN) Nasseri, B ; Alizadeh, E ; Bani, F ; Davaran, S ; Akbarzadeh, A ; Rabiee, N ; Bahadori, A ; Ziaei, M ; Bagherzadeh, M ; Saeb, M. R ; Mozafari, M ; Hamblin, M. R ; Sharif University of Technology
    American Institute of Physics Inc  2022
    Abstract
    In recent years, the role of optically sensitive nanomaterials has become powerful moieties in therapeutic techniques and has become particularly emphasized. Currently, by the extraordinary development of nanomaterials in different fields of medicine, they have found new applications. Phototherapy modalities, such as photothermal therapy (PTT) by toxic heat generation and photodynamic therapy (PDT) by reactive oxygen species, are known as promising phototherapeutic techniques, which can overcome the limitations of conventional protocols. Moreover, nanomaterial-based PDT and PTT match the simultaneous immune therapy and increase the immune system stimulation resulting from the denaturation of... 

    Shadow of cyber ostracism over remote environment: Implication on remote work challenges, virtual work environment and employee mental well-being during a Covid-19 pandemic

    , Article Acta Psychologica ; Volume 225 , 2022 ; 00016918 (ISSN) Yang, L ; Murad, M ; Mirza, F ; Chaudhary, N. I ; Saeed, M ; Sharif University of Technology
    Elsevier B.V  2022
    Abstract
    This study aimed to identify the influence of workplace cyber ostracism on employee online work engagement and employee mental well-being with the mediating roles of remote work challenges such as loneliness, procrastination, work-home interference, and ineffective communication. As amidst lockdown due to COVID-19, the data was collected from 303 respondents through an online questionnaire that was distributed in virtual groups among friends, relatives, and other fellows who were working in the private sector organizations of Pakistan. The hypotheses were tested using the partial least square structural equation modeling PLS-SEM technique. The findings of this study showed that workplace... 

    MRI-PET image fusion based on NSCT transform using local energy and local variance fusion rules

    , Article Journal of Medical Engineering and Technology ; Vol. 38, issue. 4 , 2014 , p. 211-219 Amini, N ; Fatemizadeh, E ; Behnam, H ; Sharif University of Technology
    Abstract
    Image fusion means to integrate information from one image to another image. Medical images according to the nature of the images are divided into structural (such as CT and MRI) and functional (such as SPECT, PET). This article fused MRI and PET images and the purpose is adding structural information from MRI to functional information of PET images. The images decomposed with Nonsubsampled Contourlet Transform and then two images were fused with applying fusion rules. The coefficients of the low frequency band are combined by a maximal energy rule and coefficients of the high frequency bands are combined by a maximal variance rule. Finally, visual and quantitative criteria were used to... 

    Protein fibrillation and nanoparticle interactions: Opportunities and challenges

    , Article Nanoscale ; Volume 5, Issue 7 , Jan , 2013 , Pages 2570-2588 ; 20403364 (ISSN) Mahmoudi, M ; Kalhor, H. R ; Laurent, S ; Lynch, I ; Sharif University of Technology
    2013
    Abstract
    Due to their ultra-small size, nanoparticles (NPs) have distinct properties compared with the bulk form of the same materials. These properties are rapidly revolutionizing many areas of medicine and technology. NPs are recognized as promising and powerful tools to fight against the human brain diseases such as multiple sclerosis or Alzheimer's disease. In this review, after an introductory part on the nature of protein fibrillation and the existing approaches for its investigations, the effects of NPs on the fibrillation process have been considered. More specifically, the role of biophysicochemical properties of NPs, which define their affinity for protein monomers, unfolded monomers,... 

    Discriminating early stage AD patients from healthy controls using synchronization analysis of EEG

    , Article 2011 6th International Conference on Digital Information Management, ICDIM 2011 ; 2011 , Pages 282-287 ; 9781457715389 (ISBN) Jalili, M ; Sharif University of Technology
    Abstract
    In this paper we study how the meso-scale and micro-scale electroencephalography (EEG) synchronization measures can be used for discriminating patients suffering from Alzheimer's disease (AD) from normal control subjects. To this end, two synchronization measures, namely power spectral density and multivariate phase synchronization, are considered and the topography of the changes in patients vs. Controls is shown. The AD patients showed increased power spectral density in the frontal area in theta band and widespread decrease in the higher frequency bands. It was also characterized with decreased multivariate phase synchronization in the left fronto-temporal and medial regions, which was... 

    Margination and adhesion of micro- and nanoparticles in the coronary circulation: a step towards optimised drug carrier design

    , Article Biomechanics and Modeling in Mechanobiology ; 2017 , Pages 1-17 ; 16177959 (ISSN) Forouzandehmehr, M ; Shamloo, A ; Sharif University of Technology
    Abstract
    Obstruction of left anterior descending artery (LAD) due to the thrombosis or atherosclerotic plaques is the leading cause of death worldwide. Targeted delivery of drugs through micro- and nanoparticles is a very promising approach for developing new strategies in clot-busting or treating restenosis. In this work, we modelled the blood flow characteristics in a patient-specific reconstructed LAD artery by the fluid–solid interaction method and based on physiological boundary conditions. Next, we provided a Lagrangian description of micro- and nanoparticles dynamics in the blood flow considering their Brownian motion and the particle–particle interactions. Our results state that the number of... 

    A Postural control model to assess the improvement of balance rehabilitation in parkinson's disease

    , Article Proceedings of the IEEE RAS and EMBS International Conference on Biomedical Robotics and Biomechatronics, 26 August 2018 through 29 August 2018 ; Volume 2018-August , 2018 , Pages 1019-1024 ; 21551774 (ISSN) ; 9781538681831 (ISBN) Rahmati, Z ; Behzadipour, S ; Schouten, A. C ; Taghizadeh, G ; Sharif University of Technology
    Abstract
    Studies have shown that balance and mobility in people with Parkinson's disease (PD) can improve through rehabilitation interventions. However, until now no quantitative method investigated how these patients improve their balance control. In this study, a single inverted pendulum model with PID controller was used to describe the improvement of forty PD patients after a 12-session therapy program, and to compare their balance with twenty healthy subjects. The Center of Pressure (COP) data were recorded in seven sensory conditions - on rigid and foam surface, each with eyes open and closed, and with visual disturbance; and stance on rigid surface with attached vibrator to the Achilles... 

    Bioengineering approaches for corneal regenerative medicine

    , Article Tissue Engineering and Regenerative Medicine ; Volume 17, Issue 5 , July , 2020 , Pages 567-593 Mahdavi, S. S ; Abdekhodaie, M. J ; Mashayekhan, S ; Baradaran Rafii, A ; Djalilian, A. R ; Sharif University of Technology
    Korean Tissue Engineering and Regenerative Medicine Society  2020
    Abstract
    Background:: Since the cornea is responsible for transmitting and focusing light into the eye, injury or pathology affecting any layer of the cornea can cause a detrimental effect on visual acuity. Aging is also a reason for corneal degeneration. Depending on the level of the injury, conservative therapies and donor tissue transplantation are the most common treatments for corneal diseases. Not only is there a lack of donor tissue and risk of infection/rejection, but the inherent ability of corneal cells and layers to regenerate has led to research in regenerative approaches and treatments. Methods:: In this review, we first discussed the anatomy of the cornea and the required properties for... 

    Delay-Independent regulation of blood glucose for type-1 diabetes mellitus patients via an observer-based predictor feedback approach by considering quantization constraints

    , Article European Journal of Control ; Volume 63 , January , 2021 , Pages 240-252 ; 09473580 (ISSN) Golestani, F ; Tavazoei, M. S ; Sharif University of Technology
    Elsevier Ltd  2021
    Abstract
    Diabetes, as a widespread chronic disease, is caused by the increase of blood glucose concentration (BGC) due to pancreatic insulin production failure and/or insulin resistance in the body. The artificial pancreas (AP) known as a closed-loop insulin delivery control system consists of a glucose sensor for BGC measurement, a control algorithm for calculation of exogenous insulin delivery rate (IDR), and an insulin infusion pump. The AP provides a closed-loop glucose-insulin regulatory system for type-1 diabetes mellitus (T1DM) patients in order to effectively reduce the high BGC level. In this paper, we aim to design a controller in order to regulate the BGC of T1DM patients at its basal... 

    Observer-based controller for treatment of hepatitis C infection using fractional order model

    , Article Mathematical Methods in the Applied Sciences ; Volume 45, Issue 17 , 2022 , Pages 10689-10709 ; 01704214 (ISSN) Zeinali, S ; Shahrokhi, M ; Pishro, A ; Sharif University of Technology
    John Wiley and Sons Ltd  2022
    Abstract
    In this study, a stable observer-based feedback controller has been designed for treatment of hepatitis C infectious disease under interferon (IFN) therapy. In order to consider the memory behavior and uncertain nature of this biological system, an unknown dynamics fractional-order (FO) model has been utilized for describing the interactions between the healthy cells, infected cells, and hepatitis C virus (HCV). To cope with unknown dynamics, the fuzzy logic system (FLS) has been utilized. Limitation of the drug efficacy due to its negative side effects has been taken into account as an input saturation. In order to estimate the unknown states which are required for treatment, a full-order... 

    Delay-Independent regulation of blood glucose for type-1 diabetes mellitus patients via an observer-based predictor feedback approach by considering quantization constraints

    , Article European Journal of Control ; Volume 63 , 2022 , Pages 240-252 ; 09473580 (ISSN) Golestani, F ; Tavazoei, M. S ; Sharif University of Technology
    Elsevier Ltd  2022
    Abstract
    Diabetes, as a widespread chronic disease, is caused by the increase of blood glucose concentration (BGC) due to pancreatic insulin production failure and/or insulin resistance in the body. The artificial pancreas (AP) known as a closed-loop insulin delivery control system consists of a glucose sensor for BGC measurement, a control algorithm for calculation of exogenous insulin delivery rate (IDR), and an insulin infusion pump. The AP provides a closed-loop glucose-insulin regulatory system for type-1 diabetes mellitus (T1DM) patients in order to effectively reduce the high BGC level. In this paper, we aim to design a controller in order to regulate the BGC of T1DM patients at its basal...