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disease-specific-protein-corona
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Sensing of alzheimer's disease and multiple sclerosis using nano-bio interfaces
, Article Journal of Alzheimer's Disease ; Volume 59, Issue 4 , 2017 , Pages 1187-1202 ; 13872877 (ISSN) ; Ghasemi, F ; Aghaverdi, H ; Raoufi, M ; Linnef, U ; Atyabi, F ; Nabipour, I ; Azhdarzadeh, M ; Derakhshankhah, H ; Lotfabadi, A ; Bargahi, A ; Alekhamis, Z ; Aghaie, A ; Hashemi, E ; Tafakhori, A ; Aghamollaii, V ; Mashhadi, M. M ; Sheibani, S ; Vali, H ; Mahmoudi, M ; Sharif University of Technology
Abstract
It is well understood that patients with different diseases may have a variety of specific proteins (e.g., type, amount, and configuration) in their plasmas. When nanoparticles (NPs) are exposed to these plasmas, the resulting coronas may incorporate some of the disease-specific proteins. Using gold (Au) NPs with different surface properties and corona composition, we have developed a technology for the discrimination and detection of two neurodegenerative diseases, Alzheimer's disease (AD) and multiple sclerosis (MS). Applying a variety of techniques, including UV-visible spectra, colorimetric response analyses and liquid chromatography-tandem mass spectrometry, we found the corona-NP...