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dissolution-rate-enhancement
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Preparation and characterization of raloxifene nanoparticles using Rapid Expansion of Supercritical Solution (RESS)
, Article Journal of Supercritical Fluids ; Volume 63 , 2012 , Pages 169-179 ; 08968446 (ISSN) ; Karimi Sabet, J ; Fattahi, A ; Golzary, A ; Rafiee Tehrani, M ; Dorkoosh, F. A ; Sharif University of Technology
2012
Abstract
One of the key factors in drug's efficacy is the value of their bioavailability that increases by the reduction of particle size through improvement of dissolution rate. In this study, raloxifene particle size was reduced by Rapid Expansion of Supercritical Solution (RESS). The effect of extraction temperature (40-80 °C), extraction pressure (10-18 MPa) and spray distance (5-10 cm) were investigated on size and particle size distribution of the nanoparticles. Particles were characterized using X-ray diffraction (XRD), Fourier Transform Infrared Analysis (FTIR), Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy (SEM) and Dynamic Light Scattering (DLS). The average size of...