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Screening of glypican-6 expression in benign, primary and metastatic colon cancers
, Article Clinical Medicine Insights: Oncology ; Volume 15 , 2021 ; 11795549 (ISSN) ; Alshammari, F. O. F. O ; Youssef, A. M. M ; Al Sarayreh, S ; Al Sarayra, Y. M ; Aborajooh, E ; Al Shuneigat, J ; Alrawashdeh, H. M ; Sharif University of Technology
SAGE Publications Ltd
2021
Abstract
Background: The development of colon cancer has been described as a multistep process of carcinogenesis. Understanding molecular and cellular changes underlying this process is required to determine potential biomarkers and therapeutic targets in colon cancers. Several molecular entities, including glypicans, are implicated in cancer development. Among these is glypican-6, which is overexpressed in a limited number of cancers. This study aims to characterise the glypican-6 expression in different types of colon cancer. Methods: Immunohistochemistry was used to characterise glypican-6 expression in a panel of archived formalin-fixed, paraffin-embedded colon tissue types. These types included...
Cytochrome 4Z1 expression is associated with unfavorable survival in triple-negative breast cancers
, Article Breast Cancer: Targets and Therapy ; Volume 13 , 2021 , Pages 565-574 ; 11791314 (ISSN) ; Alshammari, F. O. F. O ; Youssef, A. M. M ; Al Tarawneh, F ; Al Sarayreh, S ; Almuhaisen, G. H ; Satari, A. O ; Al Shuneigat, J ; Alrawashdeh, H. M ; Sharif University of Technology
Dove Medical Press Ltd
2021
Abstract
Purpose: Triple-negative breast cancer (TNBC) is characterized by high mortality rate, and its clinical management is difficult and complex. Therefore, there is a need for extensive efforts aimed at accelerating the discovery of novel therapies for TNBC. CYP4Z1 has been implicated in the development of breast cancer. The current study aimed at characterizing the expression of CYP4Z1 on TNBC. Materials and Methods: Using immunohistochemistry, CYP4Z1 expression was evaluated on 122 TNBC samples, four samples of breast cancers expressing ER, PR, and HER-2, and four samples of normal breast tissues. The association between the enzyme and various histopathological features and survival of...
Cytochrome 4z1 expression is correlated with poor prognosis in patients with cervical cancer
, Article Current Oncology ; Volume 28, Issue 5 , 2021 , Pages 3573-3584 ; 17187729 (ISSN) ; Alshammari, F. O. F. O ; Youssef, A. M. M ; Al Sarayra, Y. M ; Al Saraireh, R. A ; Al Muhaisen, G. H ; Al Mahdy, Y. S ; Al Kharabsheh, A. M ; Abufraijeh, S. M ; Al Rawashdeh, H. M ; Sharif University of Technology
MDPI
2021
Abstract
Background: cervical cancer is one of the most common malignancies in women worldwide and its management remains challenging and complex. As Cytochrome4Z1 (CYP4Z1) is overex-pressed in many tumours, its expression in cervical cancer is unknown. Therefore, the present study aimed to evaluate CYP4Z1 expression in cervical cancers. Methods: CYP4Z1 expression was immunohistochemically assessed in 100 cases of cervical cancers along with ten normal cervix tissues, and the enzyme’s relationship to several clinicopathological features and survival was explored. Results: CYP4Z1 was strongly expressed in 55% of cervical cancer patients. Normal cervix samples were negative for CYP4Z1 expression....