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Biomimetic sensor for dobutamine employing Nano- TiO2/Nafion/carbon nanoparticles modified electrode
, Article Electroanalysis ; Volume 28, Issue 5 , 2016 , Pages 970-978 ; 10400397 (ISSN) ; Ghalkhani, M ; Kohansal, R ; Mohammadi, R ; Sharif University of Technology
Wiley-VCH Verlag
2016
Abstract
A novel voltammetric biosensor based on nano-TiO2/nafion/carbon nanoparticles modified glassy carbon electrode (TiO2/N/CNP/GCE) was developed for the determination of dobutamine (DBA). Characterization of the surface morphology and property of TiO2/N/CNP layer was carried out by the scanning electron microscopy and atomic force microscopy. The electrochemical performance of the modified electrode was investigated by means of the cyclic voltammetry, differential pulse voltammetry and electrochemical impedance spectroscopy techniques. Effective experimental variables, such as the scan rate, pH of the supporting electrolyte, drop size of the casted modifier suspension and accumulation...
, M.Sc. Thesis Sharif University of Technology ; Shahrokhian, Saeed (Supervisor)
Abstract
This experimental work is of two parts. First, self-assembled monolayers of cysteamine was formed on the gold electrode surface which leaded to the formation of amine groups on the surface; then amine bond was formed between these amine groups and the carboxylic acid groups of acid treated multi-walled carbon nanotubes (MWCNTs). The modified electrode was used for voltammetric determination of dopamine in the presence of uric acid. In the second part, acid treated MWCNTs were decorated with ruthenium nanoparticles; then the resulting composite was used for surface modification with the exact same procedure as the first part. Ruthenium nanoparticles on the electrode surface were...
This experimental work is of two parts. First, self-assembled monolayers of cysteamine was formed on the gold electrode surface which leaded to the formation of amine groups on the surface; then amine bond was formed between these amine groups and the carboxylic acid groups of acid treated multi-walled carbon nanotubes (MWCNTs). The modified electrode was used for voltammetric determination of dopamine in the presence of uric acid. In the second part, acid treated MWCNTs were decorated with ruthenium nanoparticles; then the resulting composite was used for surface modification with the exact same procedure as the first part. Ruthenium nanoparticles on the electrode surface were...
Preparation and Study of the Electrochemical Ptal Oxide Particles/Carbon Nanoparticles: Application to Pharmaceutical Determinations
, M.Sc. Thesis Sharif University of Technology ; Shahrokhian, Saeed (Supervisor)
Abstract
In the first work, a novel voltammetric biosensor basedon TiO2-nafion-carbon nanoparticles modified glassy carbon electrode (TiO2/N/CNP/GCE) was developed for the determination of DBA. The electrochemical performance of the modified electrode was investigated by means of cyclic voltammetry (CV), different pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS) techniques. Characterization of the surface morphology and properties of TiO2/N/CNP was carried out by scanning electron microscopy (SEM) and atomic force microscopy (AFM). Effective experimental variables, such as scan rate, pH of the supporting electrolyte, drop size of the cast modifier suspension and accumulation...
In-situ electro-polymerization of graphene nanoribbon/polyaniline composite film: Application to sensitive electrochemical detection of dobutamine
, Article Sensors and Actuators, B: Chemical ; Vol. 196 , June , 2014 , pp. 582-588 ; ISSN: 09254005 ; Shahrokhian, S ; Zad, A. I ; Jokar, E ; Sharif University of Technology
Abstract
The present paper demonstrates the capability of narrow graphene nanoribbons (GNRs) in constructing new sensing platforms. Graphene nanoribbons have been synthesized via a simple solvothermal route through unzipping of carbon nanotubes, which was confirmed by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and Raman spectroscopy analysis. These narrow carbon sheets were used to form a composite film by in-situ electro-polymerization with aniline. The produced graphene nanoribbon/polyaniline (GNR/PANI) composite film showed impressive performance in electrochemical determination of dobutamine (DBT). Under optimal conditions, in comparison to...
Review on alzheimer's disease: inhibition of amyloid beta and tau tangle formation
, Article International Journal of Biological Macromolecules ; Volume 167 , 2021 , Pages 382-394 ; 01418130 (ISSN) ; Hadi Zadeh, E ; Hasan Khan, R ; Sharif University of Technology
Elsevier B.V
2021
Abstract
It is reported that approximately 40 million people are suffering from dementia, globally. Dementia is a group of symptoms that affect neurons and cause some mental disorders, such as losing memory. Alzheimer's disease (AD) which is known as the most common cause of dementia, is one of the top medical care concerns across the world. Although the exact sources of the disease are not understood, is it believed that aggregation of amyloid-beta (Aβ) outside of neuron cells and tau aggregation or neurofibrillary tangles (NFTs) formation inside the cell may play crucial roles. In this paper, we are going to review studies that targeted inhibition of amyloid plaque and tau protein tangle formation,...