Search for: dopamine-receptor
A smartphone-based fluorescent electronic tongue for tracing dopaminergic agents in human urine, Article ACS Chemical Neuroscience ; Volume 12, Issue 17 , 2021 , Pages 3157-3166 ; 19487193 (ISSN) ; Bigdeli, A ; Hormozi Nezhad, M. R ; Sharif University of Technology
American Chemical Society 2021
The importance of tracing dopaminergic agents in the progression assessment of Parkinson's disease has boosted the demand for fast, sensitive, and real-time multi-analyte detection. Herein, visual and fingerprint fluorimetric patterns have been created by an optical sensor array to simultaneously detect and discriminate among levodopa, carbidopa, benserazide, and entacapone, as important dopaminergic agents. A dual emissive nanoprobe consisting of red quantum dots and blue carbon dots with an overall pink emission has been fabricated to provide unique emission patterns in the presence of the target analytes. The sensor elements in the array come from it's differential response in the absence...
Individual differences in nucleus accumbens dopamine receptors predict development of addiction-like behavior: A computational approach, Article Neural Computation ; Volume 22, Issue 9 , 2010 , Pages 2334-2368 ; 08997667 (ISSN) ; Keramati, M. M ; Dezfouli, A ; Lucas, C ; Mokri, A ; Sharif University of Technology
Clinical and experimental observations show individual differences in the development of addiction. Increasing evidence supports the hypothesis that dopamine receptor availability in the nucleus accumbens (NAc) predisposes drug reinforcement. Here, modeling striatal-midbrain dopaminergic circuit, we propose a reinforcement learning model for addiction based on the actor-critic model of striatum. Modeling dopamine receptors in the NAc as modulators of learning rate for appetitive-but not aversive-stimuli in the critic-but not the actor-we define vulnerability to addiction as a relatively lower learning rate for the appetitive stimuli, compared to aversive stimuli, in the critic. We...
Anxiety and cognitive load affect upper limb motor control in Parkinson's disease during medication phases, Article Annals of the New York Academy of Sciences ; Volume 1494, Issue 1 , 2021 , Pages 44-58 ; 00778923 (ISSN) ; Mehdizadeh, H ; Azad, A ; Mehdizadeh, M ; Reyhanian, E ; Saberi, Z. S ; Meimandi, M ; Soltanzadeh, A ; Roohi Azizi, M ; Vasaghi Gharamaleki, B ; Parnianpour, M ; Khalaf, K ; Taghizadeh, G ; Sharif University of Technology
John Wiley and Sons Inc 2021
Anxiety is among the most debilitating nonmotor symptoms of Parkinson's disease (PD). This study aimed to determine how PD patients with low and high levels of anxiety (LA-PD and HA-PD, respectively) compare with age- and sex-matched controls at the level of motor control of reach-to-grasp movements during single- and dual-task conditions with varying complexity. Reach-to-grasp movement kinematics were assessed in 20 LA-PD, 20 HA-PD, and 20 sex- and age-matched healthy controls under single- as well as easy and difficult dual-task conditions. Assessment of PD patients was performed during both the on- and off-drug phases. The results obtained during dual-task conditions reveal deficits in...
Mining the potential of label-free biosensors for in vitro antipsychotic drug screening, Article Biosensors ; Volume 8, Issue 1 , 2018 ; 20796374 (ISSN) ; Soler, M ; Fahimi Kashani, N ; Altug, H ; Carrara, S ; Sharif University of Technology
MDPI AG 2018
The pharmaceutical industry is facing enormous challenges due to high drug attribution rates. For the past decades, novel methods have been developed for safety and efficacy testing, as well as for improving early development stages. In vitro screening methods for drug-receptor binding are considered to be good alternatives for decreasing costs in the identification of drug candidates. However, these methods require lengthy and troublesome labeling steps. Biosensors hold great promise due to the fact that label-free detection schemes can be designed in an easy and low-cost manner. In this paper, for the first time in the literature, we aimed to compare the potential of label-free optical and...