Search for: drug-accumulation
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    Stimulus-responsive polymeric nanogels as smart drug delivery systems

    , Article Acta Biomaterialia ; Volume 92 , 2019 , Pages 1-18 ; 17427061 (ISSN) Hajebi, S ; Rabiee, N ; Bagherzadeh, M ; Ahmadi, S ; Rabiee, M ; Roghani Mamaqani, H ; Tahriri, M ; Tayebi, L ; Hamblin, M. R ; Sharif University of Technology
    Acta Materialia Inc  2019
    Nanogels are three-dimensional nanoscale networks formed by physically or chemically cross-linking polymers. Nanogels have been explored as drug delivery systems due to their advantageous properties, such as biocompatibility, high stability, tunable particle size, drug loading capacity, and possible modification of the surface for active targeting by attaching ligands that recognize cognate receptors on the target cells or tissues. Nanogels can be designed to be stimulus responsive, and react to internal or external stimuli such as pH, temperature, light and redox, thus resulting in the controlled release of loaded drugs. This “smart” targeting ability prevents drug accumulation in... 

    Electrostatic accumulation and determination of triclosan in ultrathin carbon nanoparticle composite film electrodes

    , Article Analytica Chimica Acta ; Volume 593, Issue 1 , 2007 , Pages 117-122 ; 00032670 (ISSN) Amiri, M ; Shahrokhian, S ; Psillakis, E ; Marken, F ; Sharif University of Technology
    A film composed of carbon nanoparticles and poly(diallyldimethylammonium chloride) or CNP-PDDAC is formed in a layer-by-layer deposition process at tin-doped indium oxide (ITO) substrates. Excess positive binding sites within this film in aqueous phosphate buffer at pH 9.5 are quantified by adsorption of iron(III)phthalocyanine tetrasulfonate and indigo carmine. Both anionic redox systems bind with Langmuirian characteristics (K ≈ 105 mol-1 dm3) and show electrochemical reactivity throughout the film at different thicknesses. Therefore, the electrical conductivity in CNP-PDDAC films is good and the positive binding sites are approximately 140 pmol cm-2 per layer. Structural instability of... 

    The effect of hematocrit and nanoparticles diameter on hemodynamic parameters and drug delivery in abdominal aortic aneurysm with consideration of blood pulsatile flow

    , Article Computer Methods and Programs in Biomedicine ; Volume 195 , October , 2020 Jafarzadeh, S ; Nasiri Sadr, A ; Kaffash, E ; Goudarzi, S ; Golab, E ; Karimipour, A ; Sharif University of Technology
    Elsevier Ireland Ltd  2020
    Background and Objective: The present article has simulated to investigate the efficient hemodynamic parameters, the drug persistence, and drug distribution on an abdominal aortic aneurysm. Methods: Blood as a non-Newtonian fluid enters the artery acting as a real pulse waveform; its behavior is dependent on hematocrit and strain rate. In this simulation of computational fluid dynamic, magnetic nanoparticles of iron oxide which were in advance coated with the drug, are injected into the artery during a cardiac cycle. A two-phase model was applied to investigate the distribution of these carriers. Results: The results are presented for different hematocrits and the nanoparticle diameter. It... 

    Fabrication of chitosan/poly(lactic acid)/graphene oxide/TiO2 composite nanofibrous scaffolds for sustained delivery of doxorubicin and treatment of lung cancer

    , Article International Journal of Biological Macromolecules ; Volume 110 , 2018 , Pages 416-424 ; 01418130 (ISSN) Samadi, S ; Moradkhani, M ; Beheshti, H ; Irani, M ; Aliabadi, M ; Sharif University of Technology
    Elsevier B.V  2018
    In this work, the synthesized graphene oxide/TiO2/doxorubicin (GO/TiO2/DOX) composites were loaded into the chitosan/poly(lactic acid) (PLA) solutions to fabricate the electrospun chitosan/PLA/GO/TiO2/DOX nanofibrous scaffolds via electrospinning process. The synthesized composites and nanofibers were characterized using X-ray powder diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analysis. Three-factor three-level central composite design was used to determine the influence of PLA to chitosan ratio, TiO2/DOX content and GO/TiO2/DOX content on the release of DOX from nanofibrous scaffolds. Drug loading efficiency and drug release behavior from... 

    Recent advances in porphyrin-based nanocomposites for effective targeted imaging and therapy

    , Article Biomaterials ; Volume 232 , 2020 Rabiee, N ; Tavakkoli Yaraki, M ; Mokhtari Garakani, S ; Mokhtari Garakani, S ; Ahmadi, S ; Lajevardi, A ; Bagherzadeh, M ; Rabiee, M ; Tayebi, L ; Tahriri, M ; Hamblin, M. R ; Sharif University of Technology
    Elsevier Ltd  2020
    Porphyrins are organic compounds that continue to attract much theoretical interest, and have been called the “pigments of life”. They have a wide role in photodynamic and sonodynamic therapy, along with uses in magnetic resonance, fluorescence and photoacoustic imaging. There is a vast range of porphyrins that have been isolated or designed, but few of them have real clinical applications. Due to the hydrophobic properties of porphyrins, and their tendency to aggregate by stacking of the planar molecules they are difficult to work with in aqueous media. Therefore encapsulating them in nanoparticles (NPs) or attachment to various delivery vehicles have been used to improve delivery...