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    Design of ionic liquids containing glucose and choline as drug carriers, finding the link between QM and MD studies

    , Article Scientific Reports ; Volume 12, Issue 1 , 2022 ; 20452322 (ISSN) Kalhor, S ; Fattahi, A ; Sharif University of Technology
    Nature Research  2022
    Abstract
    Designing drug delivery systems for therapeutic compounds whose receptors are located in the cytosol of cells is challenging as a bilayer cell membrane is negatively charged. The newly designed drug delivery systems should assist the mentioned drugs in passing the membrane barriers and achieving their targets. This study concentrated on developing novel ionic liquids (ILs) that interact effectively with cell membranes. These ILs are based on glucose-containing choline and are expected to be non-toxic. The binding energies of the known pharmaceutically active ionic liquids were calculated at the B3LYP/6-311++G(d,p) level in the gas phase and compared with those of our newly designed... 

    Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems

    , Article Chemical Society Reviews ; Volume 45, Issue 5 , 2016 , Pages 1457-1501 ; 03060012 (ISSN) Karimi, M ; Ghasemi, A ; Sahandi Zangabad, P ; Rahighi, R ; Moosavi Basri, S. M ; Mirshekari, H ; Amiri, M ; Shafaei Pishabad, Z ; Aslani, A ; Bozorgomid, M ; Ghosh, D ; Beyzavi, A ; Vaseghi, A ; Aref, A. R ; Haghani, L ; Bahrami, S ; Hamblin, M. R ; Sharif University of Technology
    Royal Society of Chemistry  2016
    Abstract
    New achievements in the realm of nanoscience and innovative techniques of nanomedicine have moved micro/nanoparticles (MNPs) to the point of becoming actually useful for practical applications in the near future. Various differences between the extracellular and intracellular environments of cancerous and normal cells and the particular characteristics of tumors such as physicochemical properties, neovasculature, elasticity, surface electrical charge, and pH have motivated the design and fabrication of inventive "smart" MNPs for stimulus-responsive controlled drug release. These novel MNPs can be tailored to be responsive to pH variations, redox potential, enzymatic activation, thermal... 

    Carbon nanotubes in cancer therapy: A more precise look at the role of carbon nanotube-polymer interactions

    , Article Chemical Society Reviews ; Volume 42, Issue 12 , Feb , 2013 , Pages 5231-5256 ; 03060012 (ISSN) Adeli, M ; Soleyman, R ; Beiranvand, Z ; Madani, F ; Sharif University of Technology
    2013
    Abstract
    Despite the great potential of carbon nanotubes (CNTs) in various areas of biomedicine, concerns regarding their carcinogenicity, inefficient dispersion in aqueous solutions and biological activity in vivo still remain. One important and feasible route to overcome these barriers is modification of CNTs with polymers, which are widely studied and play a vital role in biological and biomedical fields, especially in drug delivery. This comprehensive review focuses on the achievements of our and other groups in currently used methods to functionalize the surface of CNTs with polymers to produce anticancer drug delivery systems. We have intensively studied covalent and noncovalent interactions... 

    Doxorubicin-loaded graphene oxide nanocomposites in cancer medicine: stimuli-responsive carriers, co-delivery and suppressing resistance

    , Article Expert Opinion on Drug Delivery ; Volume 19, Issue 4 , 2022 , Pages 355-382 ; 17425247 (ISSN) Ashrafizadeh, M ; Saebfar, H ; Gholami, M.H ; Hushmandi, K ; Zabolian, A ; Bikarannejad, P ; Hashemi, M ; Daneshi, S ; Mirzaei, S ; Sharifi, E ; Kumar, A.P ; Khan, H ; Heydari Sheikh Hossein, H ; Vosough, M ; Rabiee, N ; Kumar Thakur, V ; Makvandi, P ; Mishra, Y. K ; Tay, F. R ; Wang, Y ; Zarrabi, A ; Orive, G ; Mostafavi, E ; Sharif University of Technology
    Taylor and Francis Ltd  2022
    Abstract
    Introduction: The application of doxorubicin (DOX) in cancer therapy has been limited due to its drug resistance and poor internalization. Graphene oxide (GO) nanostructures have the capacity for DOX delivery while promoting its cytotoxicity in cancer. Areas covered: The favorable characteristics of GO nanocomposites, preparation method, and application in cancer therapy are described. Then, DOX resistance in cancer, GO-mediated photothermal therapy, and DOX delivery for cancer suppression are described. Preparation of stimuli-responsive GO nanocomposites, surface functionalization, hybrid nanoparticles, and theranostic applications are emphasized in DOX chemotherapy. Expert opinion: GO... 

    Multifunctional green synthesized Cu–Al layered double hydroxide (LDH) nanoparticles: anti-cancer and antibacterial activities

    , Article Scientific Reports ; Volume 12, Issue 1 , 2022 ; 20452322 (ISSN) Kiani, M ; Bagherzadeh, M ; Ghadiri, A. M ; Makvandi, P ; Rabiee, N ; Sharif University of Technology
    Nature Research  2022
    Abstract
    Doxorubicin (DOX) is a potent anti-cancer agent and there have been attempts in developing nanostructures for its delivery to tumor cells. The nanoparticles promote cytotoxicity of DOX against tumor cells and in turn, they reduce adverse impacts on normal cells. The safety profile of nanostructures is an important topic and recently, the green synthesis of nanoparticles has obtained much attention for the preparation of biocompatible carriers. In the present study, we prepared layered double hydroxide (LDH) nanostructures for doxorubicin (DOX) delivery. The Cu–Al LDH nanoparticles were synthesized by combining Cu(NO3)2·3H2O and Al(NO3)3·9H2O, and then, autoclave at 110. The green... 

    Synthesis of Nano Ceramic Powders for Drug Delivery and It’s Release

    , M.Sc. Thesis Sharif University of Technology Shahriari, Rezvan (Author) ; Nemati, Ali (Supervisor) ; Dobakhti, Faramarz (Supervisor)
    Abstract
    In this project, Fe3O4 nanoparticles were synthesized and coated with different polymeric materials for drug delivery application. For this purpose, water dispersible oleic acid(OA)- pluronic block copolymer coated magnetite iron oxide nanoparticles were synthesized that can be loaded with proper doses of cephalexin. Our data indicated that formulation of iron oxide nanoparticles was developed by optimizing the amount of oleic acid required to coat iron oxide nanoparticles and then by optimizing the amount of pluronic required to form an aqueous dispersion of oleic acid coated nanoparticles. Synthesis of magnetite nanoparticles was done by the addition of a strong base (NH4OH) to ferrous... 

    Curcumin-loaded amine-functionalized mesoporous silica nanoparticles inhibit α-synuclein fibrillation and reduce its cytotoxicity-associated effects

    , Article Langmuir ; Volume 32, Issue 50 , 2016 , Pages 13394-13402 ; 07437463 (ISSN) Taebnia, N ; Morshedi, D ; Yaghmaei, S ; Aliakbari, F ; Rahimi, F ; Arpanaei, A ; Sharif University of Technology
    American Chemical Society  2016
    Abstract
    This study aimed to develop a drug carrier based on amine-functionalized mesoporous silica nanoparticles (AAS-MSNPs) for a poorly water-soluble drug, curcumin (CUR), and to study its effects on α-synuclein (α-Syn) fibrillation and cytotoxicity. Here, we show that AAS-MSNPs possess high values of loading efficiency and capacity (33.5% and 0.45 mg drug/mg MSNPs, respectively) for CUR. It is also revealed that α-Syn species interact strongly with the CUR-loaded AAS-MSNPs, leading to a significant inhibition of the fibrillation process. Furthermore, these samples reduce the toxic effects of CUR. However, drug-loaded AAS-MSNPs do not affect the cytotoxic properties of the formed fibrils... 

    Specific targeting delivery to MUC1 overexpressing tumors by albumin-chitosan nanoparticles conjugated to DNA aptamer

    , Article International Journal of Pharmaceutics ; Volume 515, Issue 1-2 , 2016 , Pages 607-615 ; 03785173 (ISSN) Esfandyari Manesh, M ; Mohammadi, A ; Atyabi, F ; Nabavi, S. M ; Ebrahimi, S. M ; Shahmoradi, E ; Shiri Varnamkhasti, B ; Ghahremani, M. H ; Dinarvand, R ; Sharif University of Technology
    Elsevier B.V  2016
    Abstract
    Chitosan-coated human serum albumin nanoparticles were functionalized by MUC1 aptamer to obtain a selective drug carrier toward cancers overexpressing MUC1. The negative charges of albumin nanoparticles were shifted to positive charges by surface modification with chitosan, and MUC1 was conjugated through an acrylate spacer. The cytotoxicity of targeted nanoparticles was significantly more than non-aptamer nanoparticles, and also the chitosan-coated nanoparticles had more cytotoxic effects than the negatively charged albumin nanoparticles. The IC50 of targeted nanoparticles was 28 and 26% of free paclitaxel in MCF7 and T47D cells at 48 h, respectively. Confocal laser scanning electron... 

    Nanotechnology in diagnosis and treatment of coronary artery disease

    , Article Nanomedicine ; Volume 11, Issue 5 , 2016 , Pages 513-530 ; 17435889 (ISSN) Karimi, M ; Zare, H ; Bakhshian Nik, A ; Yazdani, N ; Hamrang, M ; Mohamed, E ; Sahandi Zangabad, P ; Moosavi Basri, S. M ; Bakhtiari, L ; Hamblin, M. R ; Sharif University of Technology
    Future Medicine Ltd 
    Abstract
    Nanotechnology could provide a new complementary approach to treat coronary artery disease (CAD) which is now one of the biggest killers in the Western world. The course of events, which leads to atherosclerosis and CAD, involves many biological factors and cellular disease processes which may be mitigated by therapeutic methods enhanced by nanotechnology. Nanoparticles can provide a variety of delivery systems for cargoes such as drugs and genes that can address many problems within the arteries. In order to improve the performance of current stents, nanotechnology provides different nanomaterial coatings, in addition to controlled-release nanocarriers, to prevent in-stent restenosis.... 

    Boron nitride nanotube as an antimicrobial peptide carrier: A theoretical insight

    , Article International Journal of Nanomedicine ; Volume 16 , 2021 , Pages 1837-1847 ; 11769114 (ISSN) Zarghami Dehaghani, M. Z ; Bagheri, B ; Yousefi, F ; Nasiriasayesh, A ; Mashhadzadeh, A. H ; Zarrintaj, P ; Rabiee, N ; Bagherzadeh, M ; Fierro, V ; Celzard, A ; Saeb, M. R ; Mostafavi, E ; Sharif University of Technology
    Dove Medical Press Ltd  2021
    Abstract
    Introduction: Nanotube-based drug delivery systems have received considerable attention because of their large internal volume to encapsulate the drug and the ability to penetrate tissues, cells, and bacteria. In this regard, understanding the interaction between the drug and the nanotube to evaluate the encapsulation behavior of the drug in the nanotube is of crucial importance. Methods: In this work, the encapsulation process of the cationic antimicrobial peptide named cRW3 in the biocompatible boron nitride nanotube (BNNT) was investigated under the Canonical ensemble (NVT) by molecular dynamics (MD) simulation. Results: The peptide was absorbed into the BNNT by van der Waals (vdW)... 

    Targeted nanomedicines for the treatment of bone disease and regeneration

    , Article Medicinal Research Reviews ; Volume 41, Issue 3 , 2021 , Pages 1221-1254 ; 01986325 (ISSN) Ordikhani, F ; Zandi, N ; Mazaheri, M ; Luther, G. A ; Ghovvati, M ; Akbarzadeh, A ; Annabi, N ; Sharif University of Technology
    John Wiley and Sons Inc  2021
    Abstract
    Targeted delivery by either passive or active targeting of therapeutics to the bone is an attractive treatment for various bone related diseases such as osteoporosis, osteosarcoma, multiple myeloma, and metastatic bone tumors. Engineering novel drug delivery carriers can increase therapeutic efficacy and minimize the risk of side effects. Developmnet of nanocarrier delivery systems is an interesting field of ongoing studies with opportunities to provide more effective therapies. In addition, preclinical nanomedicine research can open new opportunities for preclinical bone-targeted drug delivery; nevertheless, further research is needed to progress these therapies towards clinical... 

    In vitro study: synthesis and evaluation of Fe3O4/CQD magnetic/fluorescent nanocomposites for targeted drug delivery, MRI, and cancer cell labeling applications

    , Article Langmuir ; Volume 38, Issue 12 , 2022 , Pages 3804-3816 ; 07437463 (ISSN) Fattahi Nafchi, R ; Ahmadi, R ; Heydari, M ; Rahimipour, M. R ; Molaei, M. J ; Unsworth, L ; Sharif University of Technology
    American Chemical Society  2022
    Abstract
    In the present study, first, Fe3O4nanoparticles were functionalized using glutaric acid and then composited with CQDs. Doxorubicin (DOX) drug was loaded to evaluate the performance of the nanocomposite for targeted drug delivery applications. The XRD pattern confirmed the presence of characteristic peaks of CQDs and Fe3O4. In the FTIR spectrum, the presence of carboxyl functional groups on Fe3O4/CQDs was observed; DOX (positive charge) is loaded onto Fe3O4/CQDs (negative charge) by electrostatic absorption. FESEM and AFM images showed that the particle sizes of Fe3O4and CQDs were 23-75 and 1-3 nm, respectively. The hysteresis curves showed superparamagnetic properties for Fe3O4and Fe3O4/CQDs... 

    Particles in coronary circulation: A review on modelling for drug carrier design

    , Article Materials and Design ; Volume 216 , 2022 ; 02641275 (ISSN) Forouzandehmehr, M ; Ghoytasi, I ; Shamloo, A ; Ghosi, S ; Sharif University of Technology
    Elsevier Ltd  2022
    Abstract
    Atherosclerotic plaques and thrombosis are chronic inflammatory complications and the main manifestations of cardiovascular diseases (CVD), the leading cause of death globally. Achieving non/minimal-invasive therapeutic means for these implications in the coronary network is vital and has become an interdisciplinary concern. Accordingly, smart drug delivery systems, specifically based on micro- and nanoparticles, as a promising method to offer non/minimal-invasive therapeutic mechanisms are under active research. Notably, computational models enable us to study, design, and predict treatment strategies based on smart drug delivery systems with less time and cost compared with conventional... 

    Synthesis of Graphene Aerogel for Potential Application in Drug Delivery

    , M.Sc. Thesis Sharif University of Technology Ayazi, Hossein (Author) ; Akhavan, Omid (Supervisor) ; Raufi, Mohammad (Supervisor)
    Abstract
    Since the development of various anti-cancer drugs, numerous attempts have been made to decrease their off-target adverse effects anhance their efficiency.Among these efforts developing novel drug delivery systems have been demonstrate promising potentials and lots of carriers have reached the market and clinical phases.Although plentiful researches on different drug carriers, lots of problems in drug loading, release and final efficiency are yet remaind.In recent decade, graphene oxide and graphene aerogel have been attracted remarkable intrest as drug carriers, due to their biodegradable and biocompatible characteristics.Accordingly, in this study graphene aerogel have been synthesized... 

    PLA/PEG/HAp Nano-Composites as Drug Carriers

    , M.Sc. Thesis Sharif University of Technology Vakilzadeh, Elham (Author) ; Frounchi, Masoud (Supervisor)
    Abstract
    In recent years, the tendency to use biodegradable and biocompatible polymer nanoparticles for drug delivery applications has been increasing, the reason for this being the possibility of precise control of the drug release rate, ease of use, and no need for external Surgery after the release of the drug, increases the therapeutic efficiency of the drug and reduces the side effects with its precise transfer. In this research work, drug carrier nanocomposites were prepared from polylactic acid (PLA), polyethylene glycol (PEG) and hydroxyapatite (HAp) and for the controlled release of ciprofloxacin (CIP). It was used to treat bone infections. The drug loading efficiency for nano-carriers was... 

    Fully supramolecular vesicles as anticancer drug delivery systems

    , Article New Journal of Chemistry ; Volume 37, Issue 2 , 2013 , Pages 295-298 ; 11440546 (ISSN) Pourjavadi, A ; Adeli, M ; Yazdi, M ; Sharif University of Technology
    2013
    Abstract
    A supramolecular linear-dendritic copolymer consisting of a polystyrene backbone and hanging hyperbranched polyglycerols was prepared and characterized. Host-guest interactions between β-cyclodextrin incorporated in the core of polyglycerol as a host and aromatic rings of polystyrene as guests lead to the formation of a supramolecular linear-dendritic copolymer. Supramolecules formed micelles in aqueous solutions which were able to encapsulate and transfer paclitaxel with a high loading capacity  

    Graphene oxide in generation of nanobubbles using controllable microvortices of jet flows

    , Article Carbon ; Volume 138 , 2018 , Pages 8-17 ; 00086223 (ISSN) Jannesari, M ; Akhavan, O ; Madaah Hosseini, H. R ; Sharif University of Technology
    Elsevier Ltd  2018
    Abstract
    Spontaneous generation of nanobubbles (NBs) was developed by using a controllable platform of superfast microvortices, based on turbulent jet flows in the presence of graphene oxide (GO) sheets. Very high energy dissipation rates through discharging warm water into cold N2 aqueous solutions resulted in creation of micro/submicro-vortices. Shear stresses in these domains generated gas local supersaturations, leading to the formation of high concentration (∼109 mL−1) of stable NBs. Introducing GO sheets into the microvortex system resulted in effective manipulation of NBs by providing energetically favorable sites for prompt heterogeneous nucleation as well as stronger shear rate fluctuations.... 

    Preparation and investigation the release behaviour of wax microspheres loaded with salicylic acid

    , Article Journal of Microencapsulation ; Volume 26, Issue 6 , 2009 , Pages 485-492 ; 02652048 (ISSN) Gifani, A ; Taghizadeh, M ; Seifkordi, A. A ; Ardjmand, M ; Sharif University of Technology
    2009
    Abstract
    Salicylic acid-beeswax microspheres were prepared by melt dispersion technique. The effects of formulation parameters on the microscopic characteristic, drug loading and cumulative amount of released drug were investigated by experimental design. Results showed that all of the microparticles were spherical with porous surfaces. The average size of microspheres was 2448 m, the drug content was in the range of 2245 and the encapsulation efficiency was 4693. Drug loading was influenced by emulsification speed as a main factor. All the microspheres had a burst release initially. The emulsifier concentration did not have a significant effect on drug release. The release behaviour of microspheres... 

    Magnetic pH-responsive nanocarrier with long spacer length and high colloidal stability for controlled delivery of doxorubicin

    , Article Colloids and Surfaces B: Biointerfaces ; Vol. 116 , April , 2014 , pp. 49-54 ; ISSN: 09277765 Pourjavadi, A ; Hosseini, S. H ; Alizadeh, M ; Bennett, C ; Sharif University of Technology
    Abstract
    A novel magnetic nanocarrier with long spacer length and high colloidal stability has been prepared for effective delivery of doxorubicin (DOX). First, poly(amidoamine) (PAMAM) dendrimer was grown up onto the surface of superparamagnetic iron oxide nanoparticles to increase the loading amount of amine groups. Then, terminal amine groups were functionalized by polyethylene glycol dimethylester to increase the spacer length. Then anticancer drug DOX was covalently attached onto the system by hydrazone bond to forms a pH-sensitive nanocarrier. This system is designed to combine the advantage of magnetic targeting, high drug loading capacity, and controlled release  

    Developing hyaluronic acid microgels for sustained delivery of platelet lysate for tissue engineering applications

    , Article International Journal of Biological Macromolecules ; Volume 144 , 2020 , Pages 837-846 Jooybar, E ; Abdekhodaie, M. J ; Karperien, M ; Mousavi, A ; Alvi, M ; Dijkstra, P. J ; Sharif University of Technology
    Elsevier B.V  2020
    Abstract
    Platelet lysate (PL), a blood product that contains high concentrations of growth factors (GFs), can be considered as a cost-effective source of multiple GFs. In this study, hyaluronic acid (HA) based microgels were developed for delivery of PL proteins. Spherical microgel were prepared using a water in oil emulsion method. First, hyaluronic acid was grafted with tyramine groups, after which prepared microdroplets were crosslinked via an enzymatic reaction in the presence of hydrogen peroxide and horseradish peroxidase. Because of electrostatic interactions, these microgels are promising carriers for positively charged proteins entrapment like most of the GFs. When microgels are incubated in...