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Folic acid-functionalized niosomal nanoparticles for selective dual-drug delivery into breast cancer cells: An in-vitro investigation
, Article Advanced Powder Technology ; Volume 31, Issue 9 , 2020 , Pages 4064-4071 ; Tavakkoli Yaraki, M ; Ahmadi, S ; Chiani, M ; Nourouzian, D ; Sharif University of Technology
Elsevier B.V
2020
Abstract
In this study, a folic acid-functionalized niosome was formulated and loaded with letrozole and curcumin as a promising drug carrier system for chemotherapy of the breast cancer cells. The formulation process was optimized by varying the type of Span 80 and total lipid to drug ratio, where Span 80 and lipid to drug molar ratio of 10 resulted in the niosomes with maximum encapsulation of both drugs but minimum size. The developed niosomal formulation showed a great storage stability up to one month with the small changes in drug encapsulation efficiency and size during the storage. In addition, they showed a pH-dependent release behaviour with slow drug release at physiological pH (7.4) while...