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Preparation and investigation the release behaviour of wax microspheres loaded with salicylic acid
, Article Journal of Microencapsulation ; Volume 26, Issue 6 , 2009 , Pages 485-492 ; 02652048 (ISSN) ; Taghizadeh, M ; Seifkordi, A. A ; Ardjmand, M ; Sharif University of Technology
2009
Abstract
Salicylic acid-beeswax microspheres were prepared by melt dispersion technique. The effects of formulation parameters on the microscopic characteristic, drug loading and cumulative amount of released drug were investigated by experimental design. Results showed that all of the microparticles were spherical with porous surfaces. The average size of microspheres was 2448 m, the drug content was in the range of 2245 and the encapsulation efficiency was 4693. Drug loading was influenced by emulsification speed as a main factor. All the microspheres had a burst release initially. The emulsifier concentration did not have a significant effect on drug release. The release behaviour of microspheres...
Breakup of microdroplets in asymmetric T junctions
, Article Physical Review E - Statistical, Nonlinear, and Soft Matter Physics ; Volume 87, Issue 5 , 2013 ; 15393755 (ISSN) ; Salari, A ; Shafii, M. B ; Sharif University of Technology
2013
Abstract
Symmetric T junctions have been used widely in microfluidics to generate equal-sized microdroplets, which are applicable in drug delivery systems. A newly proposed method for generating unequal-sized microdroplets at a T junction is investigated theoretically and experimentally. Asymmetric T junctions with branches of identical lengths and different cross sections are utilized for this aim. An equation for the critical breakup of droplets at asymmetric T junctions and one for determining the breakup point of droplets are developed. A good agreement was observed between the theories (present and previous) and the experiments
Design of experiment, preparation, and in vitro biological assessment of human amniotic membrane extract loaded nanoparticles
, Article Current Pharmaceutical Biotechnology ; Volume 21, Issue 3 , 2020 , Pages 256-267 ; Atyabi, F ; Khoshayand, M. R ; Mahbod, R ; Cohan, R. A ; Akbarzadeh, I ; Bakhshandeh, H ; Sharif University of Technology
Bentham Science Publishers
2020
Abstract
Background: Human amniotic membrane grafting could be potentially useful in ocular surface complications due to tissue similarity and the presence of factors that reduce inflammation, vascu-larization, and scarring. However, considerations like donor-derived infectious risk and the requirement of an invasive surgery limit the clinical application of such treatments. Moreover, the quick depletion of bioactive factors after grafting reduces the efficacy of treatments. Therefore, in the current study, the possibility of nano delivery of the bioactive factors extracted from the human amniotic membrane to the ocular surface was investigated. Materials and Methods: Nanoparticles were prepared...