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Magnetic nanoparticles-loaded PLA/PEG microspheres as drug carriers
, Article Journal of Biomedical Materials Research - Part A ; Vol. 103, issue. 5 , SEP , 2014 , p. 1893-1898 ; Shamshiri, S ; Sharif University of Technology
Abstract
Surface-modified magnetite (Fe3O4) nanoparticles with an average size of 22 nm were prepared. The nanoparticles had a saturation magnetization of 50.7 emu g-1. Then magnetite and drug-loaded microspheres of poly (lactic acid)/poly (ethylene glycol) were prepared at various compositions. The microspheres were spherical in shape and had smooth surface. The diameter size of the microspheres ranged between about 0.2 and 4 μm. Doxorubicin hydrochloride for cancer treatment was the drug that loaded into the microspheres. The prepared microspheres were characterized by FTIR, XRD, VSM, SEM and drug-release measurements. It was found that the drug cumulative release percentage was proportional to...