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Electrophoretic encapsulation for slow release of vancomycin from perpendicular TiO2 nanotubes grown on Ti6Al4V electrodes
, Article Materials Research Express ; Volume 6, Issue 12 , 2019 ; 20531591 (ISSN) ; https://iopscience.iop.org/article/10.1088/2053-1591/ab6c98 ; Ahmadi Seyedkhani, S ; Sadrnezhaad, S. K ; Sharif University of Technology
Institute of Physics Publishing
2019
Abstract
Ordered perpendicular TiO2 nanotubes (TNT) with 405 to 952 nm length and 60 to 90 nm diameter were grown via 40 to 120 min anodization of Ti6Al4V flat substrates. The samples were called TNT-40, -60, -80, -100, and -120. Vancomycin was loaded on the bare and anodized electrodes by separate immersion and electrophoretic (EP) deposition procedures. EP loading resulted in storage capacity of 5221.86 μg cm-2 for TNT-80 which was much higher than 1036.75 μg cm-2 of immersed sample. Drug release comprised of three stages: (i) burst release (78% for the bare, and 23% for the TNT-80 sample), (ii) gradual transport (21% for the bare, and 64% for the TNT-80 sample), and (iii) equilibrium. Transfer...
Electrophoretic encapsulation for slow release of vancomycin from perpendicular TiO2 nanotubes grown on Ti6Al4V electrodes
, Article Materials Research Express ; Volume 6, Issue 12 , 2019 ; 20531591 (ISSN) ; Ahmadi Seyedkhani, S ; Sadrnezhaad, S. K ; Sharif University of Technology
Institute of Physics Publishing
2019
Abstract
Ordered perpendicular TiO2 nanotubes (TNT) with 405 to 952 nm length and 60 to 90 nm diameter were grown via 40 to 120 min anodization of Ti6Al4V flat substrates. The samples were called TNT-40, -60, -80, -100, and -120. Vancomycin was loaded on the bare and anodized electrodes by separate immersion and electrophoretic (EP) deposition procedures. EP loading resulted in storage capacity of 5221.86 μg cm-2 for TNT-80 which was much higher than 1036.75 μg cm-2 of immersed sample. Drug release comprised of three stages: (i) burst release (78% for the bare, and 23% for the TNT-80 sample), (ii) gradual transport (21% for the bare, and 64% for the TNT-80 sample), and (iii) equilibrium. Transfer...
Synthesis of magnesium-based Janus micromotors capable of magnetic navigation and antibiotic drug incorporation
, Article New Journal of Chemistry ; Volume 44, Issue 17 , 2020 , Pages 6947-6957 ; Madaah Hosseini, H. R ; Abedini, F ; Dabbagh, A ; Sharif University of Technology
Royal Society of Chemistry
2020
Abstract
In the present study, bubble-driven magnesium-based micromotors were fabricated through a shading method, and the potential of magnetic guidance of magnesium-based Janus micro/nanomotors through functionalization with superparamagnetic iron oxide nanoparticles (SPIONs) was investigated for the first time. SPIONs had physical electrostatic attraction with the positively charged magnesium spheres due to negative charges on their surfaces. It was also found that upon applying a field gradient, the micromotors’ velocity increased by 13% unlike other magnetically navigated spherical magnesium-based micromotors which only show a change in direction. In this work the cytotoxicity of the moving...