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drug-monitoring
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Evaluation of bio-compatible poly(ethylene glycol)-based solid-phase microextraction fiber for in vivo pharmacokinetic studies of diazepam in dogs
, Article Analyst ; Volume 132, Issue 7 , 2007 , Pages 672-678 ; 00032654 (ISSN) ; Zhang, X ; Musteata, F. M ; Bagheri, H ; Pawliszyn, J ; Sharif University of Technology
Royal Society of Chemistry
2007
Abstract
Solid-phase microextraction probes based on poly(ethylene glycol)/C18-bonded silica were used for in vivo monitoring of drugs from circulating blood of beagles, over a period of 8 h. After sampling, the extracted drugs were subsequently quantified by liquid chromatography coupled with tandem mass spectrometry. External calibrations in whole blood and phosphate-buffered saline were used to correlate the amount of analytes extracted in regard to the total and free concentrations in blood respectively. The probe provided sufficient sensitivity for the drugs in the blood matrix, while the need for drawing blood was eliminated. The limit of detections of the method from whole blood were 1.7, 1.4...
Fabrication and evaluation of bioresorbable scaffolds for interventional cardiology application with sufficient drug release
, Article Iranian Journal of Basic Medical Sciences ; Volume 25, Issue 3 , 2022 , Pages 372-382 ; 20083866 (ISSN) ; Sadrnezhaad, S. K ; Asefnejad, A ; Nemati, N. H ; Sharif University of Technology
Mashhad University of Medical Sciences
2022
Abstract
Objective(s): Bioresorbable scaffolds have been advocated as the new generation in interventional cardiology because they could provide temporary scaffolds and then disappear with resorption. Although, the available stents in clinical trials exhibited biosafety, efficacy, no death, and no apparent thrombosis, Mg-substrate degradation on drug release has not been investigated. Materials and Methods: Therefore, more research has been needed to legitimize the replacement of current stents with Mg-based stents. UV-Vis spectrophotometer, scanning electron microscope (SEM), X-ray diffraction (XRD), pH measurement, H2 evolution, and corrosion tests determined the change in hybrid properties and...