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A novel formulation of simvastatin nanoemulsion gel for infected wound therapy: In vitro and in vivo assessment
, Article Journal of Drug Delivery Science and Technology ; Volume 72 , 2022 ; 17732247 (ISSN) ; Ghaffari, A ; Keramati, M ; Ahmadi, S ; Dizaji, S ; Moayer, F ; Akbarzadeh, I ; Abazari, M ; razzaghi abyaneh, M ; Bakhshandeh, H ; Sharif University of Technology
Editions de Sante
2022
Abstract
Simvastatin, a well-known antihyperlipidemic drug, has antibacterial activity against a broad range of bacteria, especially Staphylococcus aureus. In present study, a nanoemulsion gel-based formulation containing Simvastatin was developed for infected wound therapy. Therefore, different formulations of Simvastatin nanoemulsion were prepared. Based on droplet size, polydispersity index and zeta potential, the best nanoemulsion formulation containing Simvastatin was selected for development of nanoemulsion gel formulation of drug using carbomer 934 as gelling agent. Thermodynamic stability of Simvastatin nanoemulsion was assessed at different conditions. The in vitro antibacterial activity...
Optimization, physicochemical characterization, and antimicrobial activity of a novel simvastatin nano-niosomal gel against E. coli and S. aureus
, Article Chemistry and Physics of Lipids ; Volume 234 , 2021 ; 00093084 (ISSN) ; Keramati, M ; Azadi, A ; Afzali, E ; Shahbazi, R ; chiani, M ; Norouzian, D ; Bakhshandeh, H ; Sharif University of Technology
Elsevier Ireland Ltd
2021
Abstract
Niosomes, as a kind of drug delivery system, is widely used for the topical delivery of lipophilic drugs. Optimization of niosomes plays an essential role in enhancing their therapeutic efficiencies. This study aims to prepare an optimized niosomal formulation of simvastatin (nSIM), a lipophilic member of statins, through the experiment (Response Surface methodology). Optimized niosomes were characterized in size, polydispersity index (PDI), entrapment efficiency (EE), stability, releasing pattern, and antimicrobial activity. The different molar ratio of surfactant and cholesterol were applied to prepare various formulation of simvastatin loaded niosome. Mean particle size and size...
Optimization, physicochemical characterization, and antimicrobial activity of a novel simvastatin nano-niosomal gel against E. coli and S. aureus
, Article Chemistry and Physics of Lipids ; Volume 234 , 2021 ; 00093084 (ISSN) ; Keramati, M ; Azadi, A ; Afzali, E ; Shahbazi, R ; chiani, M ; Norouzian, D ; Bakhshandeh, H ; Sharif University of Technology
Elsevier Ireland Ltd
2021
Abstract
Niosomes, as a kind of drug delivery system, is widely used for the topical delivery of lipophilic drugs. Optimization of niosomes plays an essential role in enhancing their therapeutic efficiencies. This study aims to prepare an optimized niosomal formulation of simvastatin (nSIM), a lipophilic member of statins, through the experiment (Response Surface methodology). Optimized niosomes were characterized in size, polydispersity index (PDI), entrapment efficiency (EE), stability, releasing pattern, and antimicrobial activity. The different molar ratio of surfactant and cholesterol were applied to prepare various formulation of simvastatin loaded niosome. Mean particle size and size...