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    KF/Al2O3-mediated N-alkylation of amines and nitrogen heterocycles and S-alkylation of thiols

    , Article Synthetic Communications ; Volume 36, Issue 23 , 2006 , Pages 3599-3607 ; 00397911 (ISSN) Matloubi Moghaddam , F ; DokhtTaimoory, S. M ; Ismaili, H ; Rezanejade Bardajee , G ; Sharif University of Technology
    KF/Al2O3 efficiently catalyzes N-alkylation of heterocyclic, primary, and secondary amines and S-alkylation of thiols with a variety of alkyl halides. The N-alkylation and S-alkylation adducts were produced in good to excellent yields and in short times. Copyright © Taylor & Francis Group, LLC  

    A new and convenient approach to heterotetracyclic benzoxazocines through addition of 1,3-dicarbonyl compounds to quinolinium salts

    , Article Tetrahedron Letters ; Volume 51, Issue 20 , April , 2010 , Pages 2704-2707 ; 00404039 (ISSN) Matloubi Moghaddam, F ; Mirjafary, Z ; Saeidian, H ; Taheri, S ; Khodabakhshi, M. R ; Sharif University of Technology
    The synthesis of a series of benzoxazocines has been achieved in good yields by tandem C-alkylation and intramolecular O-alkylation of 1,3-dicarbonyl compounds with quinolinium salts. This is a novel example of the synthesis of eight-membered rings via a tandem process, which provides a method for the synthesis of medium-ring heterocycles  

    Microreactor Synthesis of Medicine by Catalyzed Coupling Reaction

    , M.Sc. Thesis Sharif University of Technology Hashemnezhad, Emad (Author) ; Kazemeini, Mohammad (Supervisor) ; Hosseinpour, Vahid (Co-Supervisor)
    Idiopathic pulmonary fibrosis is the most common type of pulmonary fibrosis that causes ulcers inside the lungs. In addition to Nintedanib, Pirfenidone is currently the only compound approved by the US Food and Drug Administration in 2014 for the treatment of idiopathic pulmonary fibrosis. Meanwhile, in the pharmaceutical industry, drug synthesis is usually done through batch-wise processes, and pirfenidone is currently only produced through batch-wise processes. Hence, this study aims to change the synthesis method of this drug, which is traditionally performed through batch-wise processes, to a continuous flow process. Therefore, a micro-reactor technology can be adopted which offers a... 

    On water: A practical and efficient synthesis of benzoheterocycle derivatives catalyzed by nanocrystalline copper(II) oxide

    , Article Synthetic Communications ; Volume 40, Issue 4 , 2010 , Pages 607-614 ; 00397911 (ISSN) Sadjadi, S ; Hekmatshoar, R ; Ahmadi, S. J ; Hosseinpour, M ; Outokesh, M ; Sharif University of Technology
    Recyclable CuO nanoparticles provide an efficient, economic, and novel method for the synthesis of quinoxaline, benzoxazine, and benzothiazine. This method provides a wide range of substrate applicability, avoids the use of organic solvents, and gives benzoheterocycles in satisfactory yields  

    Facile and efficient one-pot protocol for the synthesis of benzoxazole and benzothiazole derivatives using molecular iodine as catalyst

    , Article Synthetic Communications ; Volume 36, Issue 17 , 2006 , Pages 2543-2548 ; 00397911 (ISSN) Matloubi Moghaddam, F ; Rezanejade Bardajee, G ; Ismaili, H ; Taimoory, S. M. D ; Sharif University of Technology
    Rapid and efficient condensation reactions of 2-aminothiophenol and 2-aminophenol with various aldehydes were carried out using I2 in solvent-free conditions with or without microwave irradiation to afford the corresponding 2-substituted benzothiazole and benzoxazole derivatives in good to excellent yields. Copyright © Taylor & Francis Group, LLC  

    Continuous Catalytic Synthesis of Medicine Through a Micro-Reactor System

    , M.Sc. Thesis Sharif University of Technology Jahangirifard, Shayan (Author) ; Kazemeini, Mohammad (Supervisor) ; Hosseinpour, Vahid (Co-Supervisor)
    In the past decades, the production of various active pharmaceutical ingredients in batch processes was common. But today, the approach of pharmaceutical companies has changed and the use of the equipment and continuous processes such as microreactors has become common for reasons of safety, better mass and heat transfer, reduction of operators, and ease of scale-up. Unlike many top-selling drugs such as Ibuprofen and Artemisinin, Clopidogrel, the world's third best-selling drug needed by cardiac patients, has been manufactured only in batch processes. Due to the increase in the average age of the population, the urgent need for the use of Plavix (clopidogrel) has increased in recent years.... 

    CFD-Assisted Design of Microreactor and Evaluation for Continuous Drug Synthesis

    , M.Sc. Thesis Sharif University of Technology Varposhti, Daniel (Author) ; Kazemeini, Mohammad (Supervisor) ; Hosseinpour, Vahid (Co-Supervisor)
    Manufacturing in many industries, such as electronics, petrochemical, automotive, and food, has long relied on continuous approaches, while the pharmaceutical industry has traditionally been processed in batch reactors. Since the beginning of the third millennium, continuous drug synthesis has received attention due to its multiple advantages over batch systems, which include process safety, adaptability, controllability, economic efficiency, scale-up, and enhancing performance. In this project, the pharmaceutical intermediate 1,4-benzodiazepine, which is usable as a precursor of diazepam and flurazepam, is continuously synthesized in a 400 microliters integrated micromixer and microreactor... 

    Highly efficient synthesis of pyrimido[4,5-d]pyrimidine-2,4-dione derivatives catalyzed by iodine

    , Article Tetrahedron Letters ; 2014 , p. 4720-4723 Moghaddam, F. M ; Khodabakhshi, M. R ; Aminaee, M ; Sharif University of Technology
    A new and efficient synthesis of pyrimido[4,5-d]pyrimidine-2,4-dione derivatives through the reaction of 6-aminouracils and N,N′-bis(arylmethylidene) arylmethane in the presence of molecular iodine as a readily available and feasible catalyst  

    Preparation of a naltrexone HCL potentiometric sensor and its application to pharmaceutical analysis and drug determination in biological fluids

    , Article Journal of Food and Drug Analysis ; Volume 19, Issue 4 , 2011 , Pages 445-451+539 ; 10219498 (ISSN) Ghorbani Bidkorbeh, F ; Shahrokhian, S ; Mohammadi, A ; Dinarvand, R ; Sharif University of Technology
    A novel ion selective electrode is fabricated for naltrexone HCl and used in pharmaceutical analysis and drug determination in biological fluids without complicated pretreatments and extractions, using direct potentiometry. The naltrexone complex with sodium tetraphenyl borate (NaTPB) is obtained by in situ soaking PVC membrane electrode in an 1 × 10 -3 M naltrexone solution. The sensor exhibited fast, reproducible and linear sub-Nernstian response over concentration range of 1 × 10 -5 - 1 × 10 -3 M with a detection limit of 5 × 10 -6 M. The membrane sensor was successfully applied to the determination of naltrexone in capsules as well as for its determination in urine and plasma samples  

    A simple and efficient total synthesis of (±)-danshexinkun A, a bioactive diterpenoid from Salvia miltiorrhiza

    , Article Tetrahedron Letters ; Volume 51, Issue 3 , 2010 , Pages 540-542 ; 00404039 (ISSN) Matloubi Moghaddam, F ; Moridi Farimani, M ; Sharif University of Technology
    An efficient 12-step route for the synthesis of the diterpenoid quinone (±)-danshexinkun A in 23% overall yield from the corresponding highly substituted stilbene using a photocyclization strategy is described  

    N-benzyl DABCO tribromide - Promoted oxidative coupling of benzyl cyanides: A convenient procedure for the synthesis of α, α′- dicyanostilbenes

    , Article Synthetic Communications ; Volume 38, Issue 11 , 2008 , Pages 1694-1702 ; 00397911 (ISSN) Matloubi Moghaddam, F ; Zargarani, D ; Boeini, H. Z ; Sharif University of Technology
    A convenient and efficient procedure was developed for preparing α,α′-icyanostilbenes through the oxidative coupling reaction of benzyl cyanide derivatives using N-benzyl DABCO tribromide as the oxidative bromination reagent in the presence of K2CO3 as a base. Copyright © Taylor & Francis Group, LLC  

    Oxidative cyclization of thiobenzanilides to benzothiazoles using N-Benzyl-DABCO tribromide under mild conditions

    , Article Synlett ; Issue 10 , 2005 , Pages 1612-1614 ; 09365214 (ISSN) Moghaddam, F. M ; Boeini, H. Z ; Sharif University of Technology
    N-benzyl-DABCO tribromide, a stable, crystalline organic ammonium tribromide (OATB), have been used as an alternative electrophilic bromine source for the efficient oxidative cyclization of thiobenzanilides to the corresponding benzothiazoles under mild conditions. © Georg Thieme Verlag Stuttgart  

    Optimization of culture medium and modeling of curdlan production from Paenibacillus polymyxa by RSM and ANN

    , Article International Journal of Biological Macromolecules ; Vol. 70, issue , Jul , 2014 , p. 463-473 Rafigh, S. M ; Yazdi, A. V ; Vossoughi, M ; Safekordi, A. A ; Ardjmand, M ; Sharif University of Technology
    Paenibacillus polymyxa ATCC 21830 was used for the production of curdlan gum for first time. A Box-Behnken experimental design was applied to optimize six variables of batch fermentation culture each at three levels. Statistical analyses were employed to investigate the direct and interactive effects of variables on curdlan production. Optimum cultural conditions were temperature (50. °C), pH (7), fermentation time (96. h), glucose (100. g/L), yeast extract (3. g/L) and agitation speed (150. rpm). The yield of curdlan production was 6.89. g/L at optimum condition medium. Response surface methodology (RSM) and artificial neural network (ANN) were used to model cultural conditions of curdlan... 

    Preparation and evaluation of bioactive and compatible starch based superabsorbent for oral drug delivery systems

    , Article Journal of Drug Delivery Science and Technology ; Volume 23, Issue 5 , 2013 , Pages 511-517 ; 17732247 (ISSN) Pourjavadi, A ; Ebrahimi, A. A ; Barzegar, S ; Sharif University of Technology
    Novel types of highly swelling hydrogels (superabsorbent) were prepared by grafting crosslinked poly acrylic acid-co-2-hydroxyethylmetacrylate (PAA-co-HEMA) chains onto starch through a free radical polymerization method. The effect of grafting variables (i.e., concentration of methylenebisacrylamide (MBA), acrylic acid/2-hydroxy methymetacrylate (AA/HEMA) weight ratio, ammonium persulfate (APS), starch, neutralization percent, were systematically optimized to achieve a hydrogel with a maximum swelling capacity. The superabsorbent (SAP) formation was confirmed by Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The controlled-release behavior of... 

    Water dispersed magnetic nanoparticles (H2O-DMNPs) of γ-Fe2O3 for multicomponent coupling reactions: A green, single-pot technique for the synthesis of tetrahydro-4H-chromenes and hexahydroquinoline carboxylates

    , Article Tetrahedron Letters ; Volume 54, Issue 26 , 2013 , Pages 3344-3347 ; 00404039 (ISSN) Rostamnia, S ; Nuri, A ; Xin, H ; Pourjavadi, A ; Hosseini, S. H ; Sharif University of Technology
    Water dispersed magnetic nanoparticles (DMNPs) of γ-Fe 2O3 represent a simple and green catalyst for the rapid three-component synthesis of tetrahydro-4H-chromene and hexahydroquinoline carboxylate skeletons via single-pot domino Knoevenagel-Michael-cyclization reactions  

    Designed amino acid feed in improvement of production and quality targets of a therapeutic monoclonal antibody

    , Article PLoS ONE ; Volume 10, Issue 10 , October , 2015 ; 19326203 (ISSN) Torkashvand, F ; Vaziri, B ; Maleknia, S ; Heydari, A ; Vossoughi, M ; Davami, F ; Mahboudi, F ; Sharif University of Technology
    Public Library of Science  2015
    Cell culture feeds optimization is a critical step in process development of pharmaceutical recombinant protein production. Amino acids are the basic supplements of mammalian cell culture feeds with known effect on their growth promotion and productivity. In this study, we reported the implementation of the Plackett-Burman (PB) multifactorial design to screen the effects of amino acids on the growth promotion and productivity of a Chinese hamster ovary DG-44 (CHO-DG44) cell line producing bevacizumab. After this screening, the amino acid combinations were optimized by the response surface methodology (RSM) to determine the most effective concentration in feeds. Through this strategy, the... 

    Central composite design with the help of multivariate curve resolution in loadability optimization of RP-HPLC to scale-up a binary mixture

    , Article Journal of Separation Science ; Volume 39, Issue 6 , 2016 , Pages 1031-1040 ; 16159306 (ISSN) Taheri, M ; Moazeni Pourasil, R. S ; Sheikh Olia Lavasani, M ; Karami, A ; Ghassempour, A ; Sharif University of Technology
    Wiley-VCH Verlag 
    Chromatographic method development for preparative targets is a time-consuming and subjective process. This can be particularly problematic because of the use of valuable samples for isolation and the large consumption of solvents in preparative scale. These processes could be improved by using statistical computations to save time, solvent and experimental efforts. Thus, contributed by ESI-MS, after applying DryLab software to gain an overview of the most effective parameters in separation of synthesized celecoxib and its co-eluted compounds, design of experiment software that relies on multivariate modeling as a chemometric approach was used to predict the optimized touching-band... 

    A new and facile synthesis of thieno[2,3-b]indole derivatives via condensation of isocyanide and indolin-2-thiones

    , Article Synlett ; Issue 7 , 2009 , Pages 1047-1050 ; 09365214 (ISSN) Matloubi Moghaddam, F ; Saeidian, H ; Mirjafary, Z ; Taheri, S ; Kheirjou, S ; Sharif University of Technology
    A new one-pot synthesis of thieno[2,3-b]indole ring systems is described. Condensation of cyclohexyl isocyanide with indolin-2-thiones yielded 3-cyclohexyaminomethylene-indolin-2-thiones, which upon reaction with α-halocarbonyl compounds produced the title compounds. © Georg Thieme Verlag Stuttgart  

    Preparation and optimization of ciprofloxacin encapsulated niosomes: A new approach for enhanced antibacterial activity, biofilm inhibition and reduced antibiotic resistance in ciprofloxacin-resistant methicillin-resistance Staphylococcus aureus

    , Article Bioorganic Chemistry ; Volume 103 , October , 2020 Mirzaie, A ; Peirovi, N ; Akbarzadeh, I ; Moghtaderi, M ; Heidari, F ; Yeganeh, F. E ; Noorbazargan, H ; Mirzazadeh, S ; Bakhtiari, R ; Sharif University of Technology
    Academic Press Inc  2020
    Ciprofloxacin is an alternative to vancomycin for treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. The objective of this study was to optimization of niosomes encapsulated ciprofloxacin and evaluate their antibacterial and anti-biofilm efficacies against ciprofloxacin-resistant methicillin-resistant S. aureus (CR-MRSA) strains. Formulation of niosomes encapsulated ciprofloxacin were optimized by changing the proportions of Tween 60, Span 60, and cholesterol. The optimized ciprofloxacin encapsulated niosomal formulations based on Span 60 and Tween 60 were prepared and characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM) and... 

    Mercaptotriazole as a nucleophile in addition to o-quinone electrochemically derived from catechol: Application to electrosynthesis of a new group of triazole compounds

    , Article Electrochemistry Communications ; Volume 7, Issue 1 , 2005 , Pages 68-73 ; 13882481 (ISSN) Shahrokhian, S ; Amiri, M ; Sharif University of Technology
    Electrochemical oxidation of catechol in the presence of 3-mercapto-1,2,4-triazole (MTA) as a nucleophile in aqueous buffered solutions was studied by cyclic voltammetry and controlled-potential coulometry. The mechanism of electrochemical reaction is confirmed by spectrophotometric tracing in various times of controlled-potential coulometry. The voltammetric and spectrophotometric foundations indicate that a 1,4 Michael addition of MTA from its thiol moiety to the electrochemically derived o-quinone is occurred. The electrochemical synthesis of Michael addition product has been successfully accomplished by controlled-potential coulometry in a divided H-type cell and the reaction product was...