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    Robust adaptive Lyapunov-based control of hepatitis B infection

    , Article IET Systems Biology ; Volume 12, Issue 2 , April , 2018 , Pages 62-67 ; 17518849 (ISSN) Aghajanzadeh, O ; Sharifi, M ; Tashakori, S ; Zohoor, H ; Sharif University of Technology
    Institution of Engineering and Technology  2018
    Abstract
    A new robust adaptive controller is developed for the control of the hepatitis B virus (HBV) infection inside the body. The non-linear HBV model has three state variables: uninfected cells, infected cells and free viruses. A control law is designed for the antiviral therapy such that the volume of infected cells and the volume of free viruses are decreased to their desired values which are zero. One control input represents the efficiency of drug therapy in inhibiting viral production and the other control input represents the efficiency of drug therapy in blocking new infection. The proposed controller ensures the stability and robust performance in the presence of parametric and... 

    Design and evaluation of vibratory shoe on balance control for elderly subjects: technical note

    , Article Disability and Rehabilitation: Assistive Technology ; Volume 13, Issue 2 , 2018 , Pages 173-177 ; 17483107 (ISSN) Aboutorabi, A ; Arazpour, M ; Farahmand, F ; Bahramizadeh, M ; Fadayevatan, R ; Abdollahi, E ; Sharif University of Technology
    Taylor and Francis Ltd  2018
    Abstract
    Background and Aim: Aging often results in a decline in somatosensory function, and such changes are associated with diminished motor performance. Input noise can enhance sensory and motor function through a mechanism known as stochastic resonance (SR). This paper describes the development and testing of a new vibrating shoe to possibly assist the elderly patients in controlling their balance and decreasing their falling risks. Technique: The new vibrating shoe was evaluated to ascertain its ability to generate appropriate random and nonlinear vibrations. The vibratory shoe performance in two young subjects with decreased foot sensation and two elderly subjects in different static and... 

    First principle simulation of coated hydroxychloroquine on Ag, Au and Pt nanoparticles

    , Article Scientific Reports ; Volume 11, Issue 1 , 2021 ; 20452322 (ISSN) Morad, R ; Akbari, M ; Rezaee, P ; Koochaki, A ; Maaza, M ; Jamshidi, Z ; Sharif University of Technology
    Nature Research  2021
    Abstract
    From the first month of the COVID-19 pandemic, the potential antiviral properties of hydroxychloroquine (HCQ) and chloroquine (CQ) against SARS-CoV-2 suggested that these drugs could be the appropriate therapeutic candidates. However, their side effects directed clinical tests towards optimizing safe utilization strategies. The noble metal nanoparticles (NP) are promising materials with antiviral and antibacterial properties that can deliver the drug to the target agent, thereby reducing the side effects. In this work, we applied both the quantum mechanical and classical atomistic molecular dynamics approaches to demonstrate the adsorption properties of HCQ/CQ on Ag, Au, AgAu, and Pt... 

    Numerical study of lorentz force interaction with micro structure in channel flow

    , Article Energies ; Volume 14, Issue 14 , 2021 ; 19961073 (ISSN) Ahmad, S ; Ali, K ; Ahmad, S ; Cai, J ; Sharif University of Technology
    MDPI AG  2021
    Abstract
    The heat transfer Magnetohydrodynamics flows have been potentially used to enhance the thermal characteristics of several systems such as heat exchangers, electromagnetic casting, adjusting blood flow, X-rays, magnetic drug treatment, cooling of nuclear reactors, and magnetic devices for cell separation. Our concern in this article is to numerically investigate the flow of an incompressible Magnetohydrodynamics micropolar fluid with heat transportation through a channel having porous walls. By employing the suitable dimensionless coordinates, the flow model equations are converted into a nonlinear system of dimensionless ordinary differential equations, which are then numerically treated for... 

    A review on computer-aided chemogenomics and drug repositioning for rational COVID-19 drug discovery

    , Article Chemical Biology and Drug Design ; Volume 100, Issue 5 , 2022 , Pages 699-721 ; 17470277 (ISSN) Maghsoudi, S ; Taghavi Shahraki, B ; Rameh, F ; Nazarabi, M ; Fatahi, Y ; Akhavan, O ; Rabiee, M ; Mostafavi, E ; Lima, E. C ; Saeb, M. R ; Rabiee, N ; Sharif University of Technology
    John Wiley and Sons Inc  2022
    Abstract
    Application of materials capable of energy harvesting to increase the efficiency and environmental adaptability is sometimes reflected in the ability of discovery of some traces in an environment―either experimentally or computationally―to enlarge practical application window. The emergence of computational methods, particularly computer-aided drug discovery (CADD), provides ample opportunities for the rapid discovery and development of unprecedented drugs. The expensive and time-consuming process of traditional drug discovery is no longer feasible, for nowadays the identification of potential drug candidates is much easier for therapeutic targets through elaborate in silico approaches,... 

    Computational modeling of drug distribution in the posterior segment of the eye: Effects of device variables and positions

    , Article Mathematical Biosciences ; Vol. 255, issue. 1 , 2014 , p. 11-20 Jooybar, E ; Abdekhodaie, M. J ; Farhadi F ; Cheng Y. L ; Sharif University of Technology
    Abstract
    A computational model was developed to simulate drug distribution in the posterior segment of the eye after intravitreal injection and ocular implantation. The effects of important factors in intravitreal injection such as injection time, needle gauge and needle angle on the ocular drug distribution were studied. Also, the influences of the position and the type of implant on the concentration profile in the posterior segment were investigated. Computational Fluid Dynamics (CFD) calculations were conducted to describe the 3D convective-diffusive transport. The geometrical model was constructed based on the human eye dimensions. To simulate intravitreal injection, unlike previous studies... 

    Computer modeling of drug distribution after intravitreal administration

    , Article World Academy of Science, Engineering and Technology ; Volume 77 , 2011 , Pages 706-716 ; 2010376X (ISSN) Haghjou, N ; Abdekhodaie, M. J ; Cheng, Y. L ; Saadatmand, M ; Sharif University of Technology
    2011
    Abstract
    Intravitreal injection (IVI) is the most common treatment for eye posterior segment diseases such as endopthalmitis, retinitis, age-related macular degeneration, diabetic retinopathy, uveitis, and retinal detachment. Most of the drugs used to treat vitreoretinal diseases, have a narrow concentration range in which they are effective, and may be toxic at higher concentrations. Therefore, it is critical to know the drug distribution within the eye following intravitreal injection. Having knowledge of drug distribution, ophthalmologists can decide on drug injection frequency while minimizing damage to tissues. The goal of this study was to develop a computer model to predict intraocular... 

    Margination and adhesion of micro- and nanoparticles in the coronary circulation: a step towards optimised drug carrier design

    , Article Biomechanics and Modeling in Mechanobiology ; 2017 , Pages 1-17 ; 16177959 (ISSN) Forouzandehmehr, M ; Shamloo, A ; Sharif University of Technology
    Abstract
    Obstruction of left anterior descending artery (LAD) due to the thrombosis or atherosclerotic plaques is the leading cause of death worldwide. Targeted delivery of drugs through micro- and nanoparticles is a very promising approach for developing new strategies in clot-busting or treating restenosis. In this work, we modelled the blood flow characteristics in a patient-specific reconstructed LAD artery by the fluid–solid interaction method and based on physiological boundary conditions. Next, we provided a Lagrangian description of micro- and nanoparticles dynamics in the blood flow considering their Brownian motion and the particle–particle interactions. Our results state that the number of... 

    Drug release from ion-exchange microspheres: Mathematical modeling and experimental verification

    , Article Biomaterials ; Volume 29, Issue 11 , 2008 , Pages 1654-1663 ; 01429612 (ISSN) Abdekhodaie, M. J ; Wu, X. Y ; Sharif University of Technology
    2008
    Abstract
    This paper presents for the first time a mathematical model for a mechanism of controlled drug release involving both ion exchange and transient counter diffusion of a drug and counterions. Numerical analysis was conducted to study the effect of different factors on drug release kinetics including environmental condition, material properties, and design parameters. The concentration profiles of counterions and drug species, the moving front of ion exchange, and three distinct regions inside a microsphere, namely unextracted region, ion-exchange region and drug diffusion region, were revealed by model prediction. The numerical results indicated that the rate of drug release increased with an... 

    Recent clinical findings on the role of kinase inhibitors in COVID-19 management

    , Article Life Sciences ; Volume 306 , 2022 ; 00243205 (ISSN) Malekinejad, Z ; Baghbanzadeh, A ; Nakhlband, A ; Baradaran, B ; Jafari, S ; Bagheri, Y ; Raei, F ; Montazersaheb, S ; Farahzadi, R ; Sharif University of Technology
    Elsevier Inc  2022
    Abstract
    The highly pathogenic, novel coronavirus disease (COVID-19) outbreak has emerged as a once-in-a-century pandemic with poor consequences, urgently calling for new therapeutics, cures, and supportive interventions. It has already affected over 250 million people worldwide; thereby, there is a need for novel therapies to alleviate the related complications. There is a paradigm shift in developing drugs and clinical practices to combat COVID-19. Several clinical trials have been performed or are testing diverse pharmacological interventions to alleviate viral load and complications such as cytokine release storm (CRS). Kinase-inhibitors have appeared as potential antiviral agents for COVID-19... 

    Benchmarking of Monte Carlo model of Siemens Oncor® linear accelerator for 18MV photon beam: determination of initial electron beam parameters

    , Article Journal of X-Ray Science and Technology ; Volume 27, Issue 6 , 2 January , 2020 , Pages 1047-1070 Najafzadeh, M ; Hoseini Ghafarokhi, M ; Bolagh, R. S. M ; Haghparast, M ; Zarifi, S ; Nickfarjam, A ; Farhood, B ; Chow, J. C. L ; Sharif University of Technology
    IOS Press  2020
    Abstract
    OBJECTIVE: This study aims to benchmark a Monte Carlo (MC) model of the 18 MV photon beam produced by the Siemens Oncor® linac using the BEAMnrc and DOSXYZnrc codes. METHODS: By matching the percentage depth doses and beam profiles calculated by MC simulations with measurements, the initial electron beam parameters including electron energy, full width at half maximum (spatial FWHM), and mean angular spread were derived for the 10×10 cm2 and 20×20 cm2 field sizes. The MC model of the 18 MV photon beam was then validated against the measurements for different field sizes (5×5, 30×30 and 40×40 cm2) by gamma index analysis. RESULTS: The optimum values for electron energy, spatial FWHM and mean... 

    Repurposing the drug, ivermectin, in COVID-19: toxicological points of view

    , Article European Journal of Medical Research ; Volume 27, Issue 1 , 2022 ; 09492321 (ISSN) Shirazi, F. M ; Mirzaei, R ; Nakhaee, S ; Nejatian, A ; Ghafari, S ; Mehrpour, O ; Sharif University of Technology
    BioMed Central Ltd  2022
    Abstract
    The global COVID-19 pandemic has affected the world’s population by causing changes in behavior, such as social distancing, masking, restricting people’s movement, and evaluating existing medication as potential therapies. Many pre-existing medications such as tocilizumab, ivermectin, colchicine, interferon, and steroids have been evaluated for being repurposed to use for the treatment of COVID-19. None of these agents have been effective except for steroids and, to a lesser degree, tocilizumab. Ivermectin has been one of the suggested repurposed medications which exhibit an in vitro inhibitory activity on SARS-CoV-2 replication. The most recommended dose of ivermectin for the treatment of... 

    Synthesis of new hybrid nanomaterials: Promising systems for cancer therapy

    , Article Nanomedicine: Nanotechnology, Biology, and Medicine ; Volume 7, Issue 6 , 2011 , Pages 806-817 ; 15499634 (ISSN) Adeli, M ; Kalantari, M ; Parsamanesh, M ; Sadeghi, E ; Mahmoudi, M ; Sharif University of Technology
    2011
    Abstract
    Polyrotaxanes consisting of cyclodextrin rings, polyethylene glycol axes and quantum dot (QD) stoppers were synthesized and characterized. The molecular self-assembly of polyrotaxanes led to spindlelike nano-objects whose shape, size and position were dominated by QD stoppers. Due to their well-defined molecular self-assemblies, carbohydrate backbone, high functionality and several types of functional groups together with the high luminescence yield, synthesized hybrid nanostructures were recognized as promising candidates for biomedical applications. The potential applications of the molecular self-assemblies as drug-delivery systems was investigated by conjugation of doxorubicin (DOX) to... 

    Margination and adhesion of micro- and nanoparticles in the coronary circulation: A step towards optimised drug carrier design

    , Article Biomechanics and Modeling in Mechanobiology ; Volume 17, Issue 1 , 2018 , Pages 205-221 ; 16177959 (ISSN) Forouzandehmehr, M ; Shamloo, A ; Sharif University of Technology
    Springer Verlag  2018
    Abstract
    Obstruction of left anterior descending artery (LAD) due to the thrombosis or atherosclerotic plaques is the leading cause of death worldwide. Targeted delivery of drugs through micro- and nanoparticles is a very promising approach for developing new strategies in clot-busting or treating restenosis. In this work, we modelled the blood flow characteristics in a patient-specific reconstructed LAD artery by the fluid–solid interaction method and based on physiological boundary conditions. Next, we provided a Lagrangian description of micro- and nanoparticles dynamics in the blood flow considering their Brownian motion and the particle–particle interactions. Our results state that the number of... 

    Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing

    , Article Advanced Drug Delivery Reviews ; Volume 123 , 2018 , Pages 33-64 ; 0169409X (ISSN) Mofazzal Jahromi, M. A ; Sahandi Zangabad, P ; Moosavi Basri, S. M ; Sahandi Zangabad, K ; Ghamarypour, A ; Aref, A. R ; Karimi, M ; Hamblin, M. R ; Sharif University of Technology
    Elsevier B.V  2018
    Abstract
    According to the latest report from the World Health Organization, an estimated 265,000 deaths still occur every year as a direct result of burn injuries. A widespread range of these deaths induced by burn wound happens in low- and middle-income countries, where survivors face a lifetime of morbidity. Most of the deaths occur due to infections when a high percentage of the external regions of the body area is affected. Microbial nutrient availability, skin barrier disruption, and vascular supply destruction in burn injuries as well as systemic immunosuppression are important parameters that cause burns to be susceptible to infections. Topical antimicrobials and dressings are generally...