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    Optimal robust control of drug delivery in cancer chemotherapy: A comparison between three control approaches

    , Article Computer Methods and Programs in Biomedicine ; Volume 112, Issue 1 , 2013 , Pages 69-83 ; 01692607 (ISSN) Moradi, H ; Vossoughi, G ; Salarieh, H ; Sharif University of Technology
    During the drug delivery process in chemotherapy, both of the cancer cells and normal healthy cells may be killed. In this paper, three mathematical cell-kill models including log-kill hypothesis, Norton-Simon hypothesis and Emax hypothesis are considered. Three control approaches including optimal linear regulation, nonlinear optimal control based on variation of extremals and H∞-robust control based on μ-synthesis are developed. An appropriate cost function is defined such that the amount of required drug is minimized while the tumor volume is reduced. For the first time, performance of the system is investigated and compared for three control strategies; applied on three nonlinear models... 

    Nonlinear adaptive control method for treatment of uncertain hepatitis B virus infection

    , Article Biomedical Signal Processing and Control ; Volume 38 , 2017 , Pages 174-181 ; 17468094 (ISSN) Aghajanzadeh, O ; Sharifi, M ; Tashakori, S ; Zohoor, H ; Sharif University of Technology
    In this paper, a nonlinear adaptive control method is presented for the treatment of the Hepatitis B Virus (HBV) infection. Nonlinear dynamics of the HBV, modeling uncertainties and three state variables (the numbers of uninfected and infected cells and free viruses) are taken into account. The proposed control law is designed for the antiviral drug input such that the number of free viruses and consequently the number of infected cells decrease to the desired values. An adaptation law is also presented to overcome modeling uncertainties by updating estimations of the system parameters during the treatment period. The stability of the process and convergence to desired state values are... 

    Modeling the Parkinson's tremor and its treatments

    , Article Journal of Theoretical Biology ; Volume 236, Issue 3 , 2005 , Pages 311-322 ; 00225193 (ISSN) Haeri, M ; Sarbaz, Y ; Gharibzadeh, S ; Sharif University of Technology
    In this paper, we discuss modeling issues of the Parkinson's tremor. Through the work we have employed physiological structure as well as functioning of the parts in brain that are involved in the disease. To obtain more practical similarity, random behaviors of the connection paths are also considered. Medication or treatment of the disease both by drug prescription and electrical signal stimulation are modeled based on the same model introduced for the disease itself. Two new medication strategies are proposed based on the model to reduce the side effects caused by the present drug prescription. © 2005 Elsevier Ltd. All rights reserved