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    Integrating evolutionary game theory into an agent-based model of ductal carcinoma in situ: Role of gap junctions in cancer progression

    , Article Computer Methods and Programs in Biomedicine ; Volume 136 , 2016 , Pages 107-117 ; 01692607 (ISSN) Malekian, N ; Habibi, J ; Zangooei, M. H ; Aghakhani, H ; Sharif University of Technology
    Elsevier Ireland Ltd 
    Background and objective There are many cells with various phenotypic behaviors in cancer interacting with each other. For example, an apoptotic cell may induce apoptosis in adjacent cells. A living cell can also protect cells from undergoing apoptosis and necrosis. These survival and death signals are propagated through interaction pathways between adjacent cells called gap junctions. The function of these signals depends on the cellular context of the cell receiving them. For instance, a receiver cell experiencing a low level of oxygen may interpret a received survival signal as an apoptosis signal. In this study, we examine the effect of these signals on tumor growth. Methods We make an... 

    Modeling of Cancer Progression by Using Evolutionary Game Theory

    , M.Sc. Thesis Sharif University of Technology Malekian Boroujeni, Negin (Author) ; Habibi, Jafar (Supervisor)
    Mathematical modeling and computer simulation are powerful tools to help cancer research because they provide a good insight of cancer progression and an efficient framework to test biological hypothesis. Most of the previous studies ignored many intracellular communication between tumor cells. Gap junction is one of the interaction ways between tumor cells which plays a crucial role in cancer progression. In the first phase of this thesis, a model of intracellular communication through gap junction using evolutionary game theory scoring is proposed. In the second phase of this thesis, cancer is modeled by Markov decision process (MDP). Given that considering nutrient level constant is one... 

    Cytochrome 4Z1 expression is associated with unfavorable survival in triple-negative breast cancers

    , Article Breast Cancer: Targets and Therapy ; Volume 13 , 2021 , Pages 565-574 ; 11791314 (ISSN) Al Saraireh, Y. M ; Alshammari, F. O. F. O ; Youssef, A. M. M ; Al Tarawneh, F ; Al Sarayreh, S ; Almuhaisen, G. H ; Satari, A. O ; Al Shuneigat, J ; Alrawashdeh, H. M ; Sharif University of Technology
    Dove Medical Press Ltd  2021
    Purpose: Triple-negative breast cancer (TNBC) is characterized by high mortality rate, and its clinical management is difficult and complex. Therefore, there is a need for extensive efforts aimed at accelerating the discovery of novel therapies for TNBC. CYP4Z1 has been implicated in the development of breast cancer. The current study aimed at characterizing the expression of CYP4Z1 on TNBC. Materials and Methods: Using immunohistochemistry, CYP4Z1 expression was evaluated on 122 TNBC samples, four samples of breast cancers expressing ER, PR, and HER-2, and four samples of normal breast tissues. The association between the enzyme and various histopathological features and survival of...