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Integrating evolutionary game theory into an agent-based model of ductal carcinoma in situ: Role of gap junctions in cancer progression
, Article Computer Methods and Programs in Biomedicine ; Volume 136 , 2016 , Pages 107-117 ; 01692607 (ISSN) ; Habibi, J ; Zangooei, M. H ; Aghakhani, H ; Sharif University of Technology
Elsevier Ireland Ltd
Abstract
Background and objective There are many cells with various phenotypic behaviors in cancer interacting with each other. For example, an apoptotic cell may induce apoptosis in adjacent cells. A living cell can also protect cells from undergoing apoptosis and necrosis. These survival and death signals are propagated through interaction pathways between adjacent cells called gap junctions. The function of these signals depends on the cellular context of the cell receiving them. For instance, a receiver cell experiencing a low level of oxygen may interpret a received survival signal as an apoptosis signal. In this study, we examine the effect of these signals on tumor growth. Methods We make an...