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    An alternative mechanism for the formation of high density lipoprotein in peripheral tissue

    , Article Scientia Iranica ; Volume 23, Issue 2 , 2016 , Pages 600-608 ; 10263098 (ISSN) Damirchi, B ; Saidi, M. S ; Rismanian, M ; Firoozabadi, B ; Amininasab, M ; Sharif University of Technology
    Sharif University of Technology  2016
    High Density Lipoprotein (HDL) is a lipid-protein complex responsible for transporting cholesterol and triglyceride molecules, as these compounds are unable to dissolve in aqueous environments such as a bloodstream. Among the most well-known possible structures, the belt-like structure is the most common shape proposed for this vital bimolecular complex. In this structure, the protein scaffold encompasses the lipid bilayer and a planar circular structure is formed. Several HDL simulations with embedded components in the lipid section were performed. Here, we applied a series of molecular dynamic simulations using the MARTINI coarse grain force field to investigate an HDL model, with pores of...