Sharif Digital Repository

Polymeric microspheres which can load biomolecules, proteins and growth factors play an important role in tissue engineering and drug delivery systems. The size of the microspheres and encapsulation efficiency exert a considerable impact on the usability of them. In this study double emulsion method is used for fabrication of microspheres. Effect of different parameters namely the speed of homogenization, time of homogenization, the amount of polymer in oil phase, the surfactant concentration in different phases on the size and surface morphology of the microspheres are investigated. Moreover, a release test for BSA loaded microspheres is conducted. Results indicate that by increasing the... 

This study is aimed at simulation of double emulsion formation in a microfluidic double flow focusing device which consists of two cross-junctions connected serially. The water in oil (w/o) emulsions are produced in the first junction. In the second junction, water in oil emulsions are encapsulated by an outer aqueous phase to generate water in oil in water (w/o/w) double emulsions. Water in oil emulsions are formed in hydrophobic channels and water in oil in water double emulsions are formed in hydrophilic channels. A three phase numerical model, based on the VOF-CSF method, is developed for simulating the process of double emulsion formation. An adaptive mesh refinement technique is...