Search for: enantiomers
0.006 seconds

    Visual recognition of tryptophan enantiomers using chiral self assemblies of quantum dots

    , Article ACS Applied Nano Materials ; 2021 ; 25740970 (ISSN) Fahimi Kashani, N ; Jafar Nezhad Ivrigh, Z ; Bigdeli, A ; Hormozi Nezhad, M.R ; Sharif University of Technology
    American Chemical Society  2021
    Discrimination of chiral targets is generally achieved with chiral nanomaterials. However, the limited number of intrinsic chiral nanostructures as well as their complex synthesis procedure has led to the production of chirality-induced nanomaterials as alternatives. Chirality can be induced in nanomaterials by either chirality transfer or the formation of chiral assemblies. Using the latter approach, in this work, we have provided chiral supramolecular assemblies of CdTe quantum dots (QDs) from achiral starting materials. CTAB-QD assemblies showed chiroptical activities, and their orange emission in combination with the blue emission of carbon dots was utilized as a ratiometric chiral... 

    Design of Chemiluminescence Sensors Enhanced by Colloidal Nanoparticles for Discrimination of Biomolecules

    , Ph.D. Dissertation Sharif University of Technology Shahrajabian, Maryam (Author) ; Hormozinezhad, Mohammad Reza (Supervisor)
    In the first part of this research, we introduce a novel chemiluminescence (CL) sensor array for discrimination of biothiols (e.g., cysteine, glutathione and glutathione disulfide). The proposed CL sensor array is based on the CL efficiencies of four types of enhanced nanoparticle-based CL systems. The intensity of CL was altered to varying degrees upon interaction with biothiols, producing unique CL response patterns. These distinct CL response patterns were collected as “fingerprints” and were then identified through chemometric methods, including linear discriminant analysis (LDA) and hierarchical cluster analysis (HCA). The developed array was able to successfully differentiate between... 

    Dissipative vibrational model for chiral recognition in olfaction

    , Article Physical Review E - Statistical, Nonlinear, and Soft Matter Physics ; Volume 92, Issue 3 , 2015 ; 15393755 (ISSN) Tirandaz, A ; Taher Ghahramani, F ; Shafiee, A ; Sharif University of Technology
    American Physical Society  2015
    We examine the olfactory discrimination of left- and right-handed enantiomers of chiral odorants based on the odorant-mediated electron transport from a donor to an acceptor of the olfactory receptors embodied in a biological environment. The chiral odorant is effectively described by an asymmetric double-well potential whose minima are associated to the left- and right-handed enantiomers. The introduced asymmetry is considered an overall measure of chiral interactions. The biological environment is conveniently modeled as a bath of harmonic oscillators. The resulting spin-boson model is adapted by a polaron transformation to derive the corresponding Born-Markov master equation with which we... 

    Efficient diastereo- and enantioselective synthesis of α,β-disubstituted γ-phosphono sulfonates

    , Article Tetrahedron Asymmetry ; Volume 20, Issue 21 , 2009 , Pages 2429-2431 ; 09574166 (ISSN) Enders, D ; Mirjafary, Z ; Saeidian, H
    The first asymmetric synthesis of α,β-disubstituted γ-phosphono sulfonates is reported. The key step is the Michael addition of a lithiated enantiopure sulfonate bearing an inexpensive chiral sugar auxiliary to α,β-unsaturated phosphonates in good diastereoselectivities. After chromatographic purification, the cleavage of the chiral sugar auxiliary proceeds without any epimerization or racemization to form the corresponding isopropyl sulfonate in very good overall yield (75%) and excellent diastereomeric and enantiomeric excess (de, ee ≥ 95%). © 2009 Elsevier Ltd. All rights reserved  

    Optical nanoprobes for chiral discrimination

    , Article Analyst ; Volume 145, Issue 20 , 2020 , Pages 6416-6434 Bigdeli, A ; Ghasemi, F ; Fahimi Kashani, N ; Abbasi Moayed, S ; Orouji, A ; Jafar Nezhad Ivrigh, Z ; Shahdost Fard, F ; Hormozi Nezhad, M. R ; Sharif University of Technology
    Royal Society of Chemistry  2020
    Chiral discrimination has always been a hot topic in chemical, food and pharmaceutical industries, especially when dealing with chiral drugs. Enantiomeric recognition not only leads to better understanding of the mechanism of molecular recognition in biological systems, but may further assist in developing useful molecular devices in biochemical and pharmaceutical studies. By emerging nanotechnology and exploiting nanomaterials in sensing applications, a great deal of attention has been given to the design of optical nanoprobes that are able to discriminate enantiomers of chiral analytes. This review explains how engineering nanoparticles (NPs) with desired physicochemical properties allows... 

    Organocatalytic synthesis of chiral benzopyrans

    , Article Tetrahedron Asymmetry ; Volume 17, Issue 12 , 2006 , Pages 1763-1767 ; 09574166 (ISSN) Govender, T ; Hojabri, L ; Matloubi Moghaddam, F ; Arvidsson, P. I ; Sharif University of Technology
    Benzopyrans, or chromenes, are widespread in nature and are considered to be a privileged scaffold in medicinal chemistry. Herein, we report the first organocatalyzed asymmetric synthesis of chiral benzopyrans. The benzopyran unit is constructed through a domino reaction involving an oxa-Michael attack of salicylic aldehyde derivatives onto α,β-unsaturated aldehydes, activated through iminium-ion formation with the organocatalyst, followed by an intramolecular aldol reaction and subsequent elimination of water. This overall reaction sequence provides benzopyrans with aromatic C-2 substituents in up to 60% yield and 60% enantioselectivity, while C-2 aliphatic analogues can be obtained in 90%... 

    Colorimetric Sensor Array Design for Classification and Detection of Nanoparticles and Some Biomolecules

    , Ph.D. Dissertation Sharif University of Technology Ghasemi, Forough (Author) ; Hormozi Nezhad, Mohammad Reza (Supervisor)
    In the first part of this research, we reported a liquid sensor array for detection and classification of biological thiols, based on aggregation of gold nanoparticles (AuNPs) with different coatings as sensor elements. Thiol mediated aggregation of AuNPs was visualized via UV–vis spectra. The spectral changes, as a consequence of aggregation of AuNPs, made a unique pattern of spectra for each analyte and allowed for the selective detection and discrimination of the biological molecules. HCA and PCA analysis demonstrated the discrimination of various thiols of different concentrations (i.e. 10–800 mmol L-1 for cysteine, 200–700 mmol L-1 for both glutathione and glutathione disulfide).... 

    Radial basis function-artificial neural network (RBF-ANN) for simultaneous fluorescent determination of cysteine enantiomers in mixtures

    , Article Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy ; Volume 261 , 2021 ; 13861425 (ISSN) Safarnejad, A ; Reza Hormozi Nezhad, M ; Abdollahi, H ; Sharif University of Technology
    Elsevier B.V  2021
    The determination of chiral compounds is critically important in chemical and pharmaceutical sciences. Cysteine amino acid is one of the important chiral compounds where each enantiomer (L and D) has different effects on fundamental physiological processes. The unique optical properties of nanoparticles make them a suitable probe for the determination of different analytes. In this work, the water-soluble thioglycolic acid (TGA)-capped cadmium-telluride (CdTe) quantum dots (QDs) were applied as optical nanoprobe for the simultaneous determination of cysteine enantiomers. The difference in the kinetics of the interactions between L- and D-cysteine with CdTe QDs is used for multivariate... 

    Shell-like instability of large diameter single-walled carbon nanotubes conveying fluid

    , Article Journal of Mechanical Science and Technology ; Volume 26, Issue 11 , 2012 , Pages 3389-3397 ; 1738494X (ISSN) Ali-Akbari, H. R ; Firouz Abadi, R. D ; Haddadpour, H ; Noorian, M. A ; Sharif University of Technology
    The instability of large diameter single-walled carbon nanotubes (SWCNTs) conveying fluid is investigated based on the molecular mechanics. Using the modal expansion for structural displacements, the governing equations of coupled fluid-structural dynamics of SWCNTs are derived. The natural frequencies and mode shape of the SWCNTs are obtained based on the molecular structural mechanics to account for the effect of chirality and discrete nature of SWCNTs. The results show that the vibrational behavior of large diameter SWCNTs conveying fluid is size dependent, but the effect of chirality is negligible. The obtained results are compared with the equivalent continuum-based model in the...