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    A model for cell density effect on stress fiber alignment and collective directional migration

    , Article Physical Biology ; Volume 12, Issue 6 , 2015 ; 14783967 (ISSN) Abeddoust, M ; Shamloo, A ; Sharif University of Technology
    In this study, numerical simulation of collective cell migration is presented in order to mimic the group migration of endothelial cells subjected to the concentration gradients of a biochemical factor. The developed 2D model incorporates basic elements of the cell, including both the cell membrane and the cell cytoskeleton, based on a viscoelastic cell mechanic model. Various cell processes - including cell random walk, cell-cell interactions, cell chemotaxis, and cellular cytoskeleton rearrangements - are considered and analyzed in our developed model. After validating the model by using available experimental data, the model is used to investigate various important parameters during...