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Liposome Nanoparticles Synthesis in order to Study the Antibiotic Drug Delivery in Simulated Environment of Body
, M.Sc. Thesis Sharif University of Technology ; Alemzadeh, Iran (Supervisor)
Abstract
In recent years, much attention has been paid to the preparation of nanoparticles as carriers for drug delivery. Nanoparticle carriers, by changing the pharmacokinetic properties of the drug, improve the function of the drug and reduce its side effects. In the manufacture of nanoparticles, various materials such as polymers, metal particles, lipids, etc. are used to transfer the drugs, which can produce a different shape and size of the particles depending on their production method. The purpose of this project is the synthesis of liposomal nanoparticles (as nano-carriers) to load an antibiotic (Eucalyptus oil) and study the release of the encapsulated drug in the simulated environment of...
Extraction and purification of phosphatidylcholine and its potential in nanoliposomal delivery of eucalyptus citriodora oil
, Article Canadian Journal of Chemical Engineering ; 2021 ; 00084034 (ISSN) ; Vaziri, A. S ; Alemzadeh, I ; Sharif University of Technology
John Wiley and Sons Inc
2021
Abstract
Phosphatidylcholine (PC) possesses amphiphilic characteristics to form vesicles or liposome nanoparticles and can be utilized to deliver essential nutrients such as proteins, peptide antigens, and essential fatty acids. In this study, an attempt has been made to obtain purified PC and evaluate its potential in nanoliposome synthesis and its corresponding drug release profile. In this regard, four physical separation techniques comprising extraction, precipitation, static, and dynamic adsorption were assessed and applied to purify PC from soybean lecithin. Different solvents and the ratio of lecithin to solvent were used to achieve the highest PC percentage. The results of an HPLC test showed...
Extraction and purification of phosphatidylcholine and its potential in nanoliposomal delivery of Eucalyptus citriodora oil
, Article Canadian Journal of Chemical Engineering ; Volume 100, Issue 10 , 2022 , Pages 2807-2814 ; 00084034 (ISSN) ; Vaziri, A. S ; Alemzadeh, I ; Sharif University of Technology
John Wiley and Sons Inc
2022
Abstract
Phosphatidylcholine (PC) possesses amphiphilic characteristics to form vesicles or liposome nanoparticles and can be utilized to deliver essential nutrients such as proteins, peptide antigens, and essential fatty acids. In this study, an attempt has been made to obtain purified PC and evaluate its potential in nanoliposome synthesis and its corresponding drug release profile. In this regard, four physical separation techniques comprising extraction, precipitation, static, and dynamic adsorption were assessed and applied to purify PC from soybean lecithin. Different solvents and the ratio of lecithin to solvent were used to achieve the highest PC percentage. The results of an HPLC test showed...