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Endurance exercise training under normal diet conditions activates skeletal muscle protein synthesis and inhibits protein degradation signaling except MuRF1
, Article Sport Sciences for Health ; Volume 18, Issue 3 , 2022 , Pages 1033-1041 ; 18247490 (ISSN) ; Seifabadi, M ; Asad, M. R ; Sharif University of Technology
Springer-Verlag Italia s.r.l
2022
Abstract
Purpose: Loss of skeletal muscle mass, which depends on a balance between protein synthesis and degradation, is common in sarcopenia, cachexia, and some diseases. The purpose of this study was to investigate the alterations and interactions of protein synthesis and degradation signaling components induced by 8-week endurance exercise training with a normal diet. Methods: Two exercise (n = 8) and control (n = 7) groups of Wistar rats were kept under standard conditions. The exercise group performed 8-week endurance running at 65–70% VO2max, 30–60 min, on a treadmill with 0° slope, and the rats of the control group were maintained under identical conditions except exercise training....
Comparing the effects of endurance and resistance trainings on gene expression involved in protein synthesis and degradation signaling pathways of Wistar rat soleus muscle
, Article Tehran University Medical Journal ; Volume 77, Issue 11 , 2020 , Pages 668-677 ; Seifabad, M ; Asad, M. R ; Sharif University of Technology
Tehran University of Medical Sciences
2020
Abstract
Background: Skeletal muscle mass, which is regulated by a balance between muscle protein synthesis and degradation, is an important factor for movement to meet everyday needs, especially in pathological conditions and aging. The purpose of the present investigation was to compare the alterations of the gene expression involved in muscle protein synthesis and degradation signaling pathways induced by two exercise training protocols. Methods: Eight weeks old Wistar rats have been assigned to the present experimental study, which was conducted from August 2018 to October 2018 at the animal laboratory of Tehran University. They were randomly divided into two resistance and endurance training...