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experimental-optimization
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Numerical investigations of hepatic spheroids metabolic reactions in a perfusion bioreactor
, Article Frontiers in Bioengineering and Biotechnology ; Volume 7 , 2019 ; 22964185 (ISSN) ; Firoozabadi, B ; Firoozbakhsh, K ; Sharif University of Technology
Frontiers Media S.A
2019
Abstract
Miniaturized culture systems of hepatic cells are emerging as a strong tool facilitating studies related to liver diseases and drug discovery. However, the experimental optimization of various parameters involved in the operation of these systems is time-consuming and expensive. Hence, developing numerical tools predicting the function of such systems can significantly reduce the associated cost. In this paper, a perfusion-based three dimensional (3D) bioreactor comprising encapsulated human liver hepatocellular carcinoma (HepG2) spheroids are analyzed. The flow and mass transfer equations for oxygen as well as different metabolites such as albumin, glucose, glutamine, ammonia, and urea were...
Micro-plasma actuator mechanisms in interaction with fluid flow for wind energy applications: Physical parameters
, Article Physics of Fluids ; Volume 32, Issue 7 , 2020 ; Mazaheri, K ; Sharif University of Technology
American Institute of Physics Inc
2020
Abstract
Plasma actuator is a flow control device to improve the aerodynamic performance of wind turbine blades at low airspeeds. One of the most robust numerical models for simulation of plasma actuator interaction with the fluid flow is the electrostatic model. This model is improved recently and is extensively verified by the authors. Due to the high cost of performing experimental optimizations, the optimized geometrical dimensions and materials of a plasma actuator may be sought by this numerical model. The aim of the present study is the aerodynamic enhancement of a DU21 wind turbine blade airfoil in which the effect of geometric parameters and the dielectric material is examined separately....
Experimental modeling and optimizing process parameters in the laser assisted machining of silicon carbide particle-reinforced aluminum matrix composites
, Article Materials Research Express ; Volume 6, Issue 8 , 2019 ; 20531591 (ISSN) ; Movahhedy, M. R ; Khodaygan, S ; Sharif University of Technology
Institute of Physics Publishing
2019
Abstract
The process of laser assisted machining (LAM) of metal matrix composites (MMC) is experimentally studied. The effects of process parameters (cutting speed, feed rate and depth of cut), laser parameters (laser power, laser frequency and laser beam angle), and the percentage of reinforcing particles on the tool wear and the surface roughness are investigated. Furthermore, the effects of the mentioned parameters on the built-up edge (BUE), chip shape, and workpiece temperature are explored. The experiments were performed using uncoated tungsten carbide and PCD tools under dry conditions. In order to analyze the sensitivity of the process parameters, the Plackett-Burman method was used for...