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Stimulus-responsive liposomes as smart nanoplatforms for drug delivery applications
, Article Nanotechnology Reviews ; 2017 ; 21919089 (ISSN) ; Mirkiani, S ; Shahsavari, S ; Masoudi, B ; Masroor, M ; Hamed, H ; Jafari, Z ; Davatgaran Taghipour, Y ; Hashemi, H ; Karimi, M ; Hamblin, M. R ; Sharif University of Technology
Abstract
Liposomes are known to be promising nanoparticles (NPs) for drug delivery applications. Among different types of self-assembled NPs, liposomes stand out for their non-toxic nature, and their possession of dual hydrophilic-hydrophobic domains. Advantages of liposomes include the ability to solubilize hydrophobic drugs, the ability to incorporate different hydrophilic and lipophilic drugs at the same time, lessening the exposure of host organs to potentially toxic drugs and allowing modification of the surface by a variety of different chemical groups. This modification of the surface, or of the individual constituents, may be used to achieve two important goals. Firstly, ligands for active...
Stimulus-responsive liposomes as smart nanoplatforms for drug delivery applications
, Article Nanotechnology Reviews ; Volume 7, Issue 1 , 2018 , Pages 95-122 ; 21919089 (ISSN) ; Mirkiani, S ; Shahsavari, S ; Masoudi, B ; Masroor, M ; Hamed, H ; Jafari, Z ; Davatgaran Taghipour, Y ; Hashemi, H ; Karimi, M ; Hamblin, M. R ; Sharif University of Technology
Walter de Gruyter GmbH
2018
Abstract
Liposomes are known to be promising nanoparticles (NPs) for drug delivery applications. Among the different types of self-assembled NPs, liposomes stand out for their non-toxic nature and their possession of dual hydrophilic-hydrophobic domains. The advantages of liposomes include the ability to solubilize hydrophobic drugs, the ability to incorporate different hydrophilic and lipophilic drugs at the same time, lessening the exposure of host organs to potentially toxic drugs and allowing modification of the surface by a variety of different chemical groups. This modification of the surface, or of the individual constituents, may be used to achieve two important goals. First, ligands for...
Effect of mechanical nonlinearity on the electromagnetic response of a microwave tunable metamaterial
, Article Journal of Physics D: Applied Physics ; Volume 55, Issue 20 , 2022 ; 00223727 (ISSN) ; Goudarzi, T ; Fleury, R ; Orazbayev, B ; Naghdabadi, R ; Sharif University of Technology
IOP Publishing Ltd
2022
Abstract
Tunable metamaterials functionalities change in response to external stimuli. Mechanical deformation is known to be an efficient approach to tune the electromagnetic response of a deformable metamaterial. However, in the case of large mechanical deformations, which are usually required to fully exploit the potential of the tunable metamaterials, the linear elastic mechanical analysis is no longer suitable. Nevertheless, nonlinear mechanical analysis is missing in the studies of mechanically tunable metamaterials. In this paper, we study the importance of considering nonlinearity in mechanical behavior when analyzing the response of a deformable metamaterial and its effects on electromagnetic...
Stimuli-responsive chitosan as an advantageous platform for efficient delivery of bioactive agents
, Article Journal of Controlled Release ; Volume 317 , 2020 , Pages 216-231 ; Tavakolian, M ; Yazdani, H ; Frounchi, M ; van de Ven, T. G. M ; Maysinger, D ; Kakkar, A ; Sharif University of Technology
Elsevier B.V
2020
Abstract
Despite a diverse range of active pharmaceutical agents currently at our disposal, high morbidity rate diseases continue to pose a major health crisis globally. One of the important parameters in this regard is the controlled cargo delivery at desired sites. Among a variety of synthetic and natural macromolecular systems, chitosan, an abundant biopolymer, offers a platform for tailored architectures that could have high loading capacity of cargo, target and deliver. Stimuli directed accumulation of vehicles and drug release is an area of direct relevance to biomedical applications. In this review, we highlight essential characteristics of modified chitosan that present themselves for...