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The use of a glucose-reduced graphene oxide suspension for photothermal cancer therapy
, Article Journal of Materials Chemistry ; Volume 22, Issue 27 , 2012 , Pages 13773-13781 ; 09599428 (ISSN) ; Ghaderi, E ; Aghayee, S ; Fereydooni, Y ; Talebi, A ; Sharif University of Technology
RSC
2012
Abstract
A single-step green method for effective reduction and functionalization of graphene oxide (GO) by glucose was developed. Then, efficacy of the glucose-reduced GO sheets in photothermal therapy of LNCaP prostate cancer cells was investigated in vitro. The GO suspension reduced and functionalized by glucose in the presence of Fe catalyst showed a biocompatible property with an excellent near-infrared (NIR) photothermal therapy efficiency better than hydrazine-reduced GO, single-wall and multi-wall carbon nanotube suspensions which even showed some levels of toxicities. For complete destruction of the cancer cells at some time intervals of NIR irradiation (e.g., 0.5 and 12 min with a power...