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    Evaluation of endothelial response to reactive hyperaemia in peripheral arteries using a physiological model

    , Article International Journal of Biomedical Engineering and Technology ; Volume 33, Issue 4 , 2020 , Pages 305-324 Parsafar, M. H ; Zahedi, E ; Vahdat, B. V ; Sharif University of Technology
    Inderscience Publishers  2020
    Non-invasive measurement of flow-mediated dilation (FMD) in the brachial artery for assessing endothelial function is costly and operator-dependent, limiting its application to research cases. In this paper, an approach based on a physiological model between normalized central blood pressure and finger photoplethysmogram is presented. Baseline model parameters are estimated using a genetic algorithm in 30 subjects consisting of ten normal blood pressure (BP), ten high-BP and ten elderly volunteers. Beat-to-beat fitness values after reactive hyperaemia are calculated using baseline (before cuff occlusion) data. Results show that stimulus-induced changes are fairly described with a first order...