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Numerical Simulation of Flow Focusing Injectors for Liquid Microjet
, M.Sc. Thesis Sharif University of Technology ; Morad, Mohammad Reza (Supervisor)
Abstract
One of the key features of multiphase flow applications is the creation of as little liquid droplets as possible. For example, it is important to use combustion to burn liquid fuels in combustion chambers, fuel-air mixing and complete evaporation of fuel. Liquid fuel should be converted into small droplets and then mixed with air quickly and evaporated. This challenge has been investigated using injectors of various designs and is still being investigated. One of the injectors used is injectors where both gas and liquid are injected into the injector and supplemented with each other. These injectors are referred to as focal injectors, in which gas flows through a typical orifice to...
Simulation of Rapid Formation of Multicellular Spheroids in Double-emulsion Droplets with Controllable Microenvironment
, M.Sc. Thesis Sharif University of Technology ; Moosavi, Ali (Supervisor) ; Sadrhosseini, Hani (Supervisor)
Abstract
This study is aimed at simulation of double emulsion formation in a microfluidic double flow focusing device which consists of two cross-junctions connected serially. The water in oil (w/o) emulsions are produced in the first junction. In the second junction, water in oil emulsions are encapsulated by an outer aqueous phase to generate water in oil in water (w/o/w) double emulsions. Water in oil emulsions are formed in hydrophobic channels and water in oil in water double emulsions are formed in hydrophilic channels. A three phase numerical model, based on the VOF-CSF method, is developed for simulating the process of double emulsion formation. An adaptive mesh refinement technique is...
Numerical Investigation of Droplet Generation in a Microfluidic Flow-Focusing Junction Aiming High-Throughput Droplet Generation
, M.Sc. Thesis Sharif University of Technology ; Taghipoor, Mojtaba (Supervisor) ; Hosseini, Vahid (Supervisor)
Abstract
Droplet microfluidic platform generates monodisperse droplets in a desired size through immiscible multiphase flows inside microchannels. Droplets are individual reactor and can be used for bio(chemical) analyses. Also, for materials fabrication, droplet microfluidics offers a versatile platform for generation of nano- or micro-sized particles and microcapsules that are widely used in drug delivery. In addition to the monodispersity, high-throughput generation is also necessary in many applications. Therefore, droplets must be formed in stable regimes (dripping and squeezing) in the highest possible frequency. In this study, the flow-focusing geometry, which is the most common geometry in...
Production of drug Loaded Microgels Using Microfluidic
, M.Sc. Thesis Sharif University of Technology ; Saadatmand, Maryam (Supervisor) ; Eskandari, Mahnaz (Supervisor)
Abstract
Microfluidic systems have the ability to produce microgels with uniform size distribution and spherical shape due to the laminar flow and better control of the flow rates. Spherical microgels with same size can be used as high-potential carriers for drug release. An important challenge in the production of these drug-carrying microgels is the simultaneous process of drug loading into microgels and their production. The overall goal of this project was to produce drug-carrying microgels with uniform size distribution that show controlled drug release. To achieve this goal, various factors such as the type of polymer, the type of drug, the volume ratio of the polymer and the drug and the...
Production of Liquid Metal Micro-droplets and Electrical Control of their Size and Rate of Formation
, M.Sc. Thesis Sharif University of Technology ; Kebriaee, Azadeh (Supervisor)
Abstract
The use of liquid metal droplets due to their high electrical and thermal conductivity are used in various industries today. One of the methods of producing these micro-droplets is the flow focusing method, which is widely used to produce integrated and monodispersed droplets. Liquid metals have high surface tension and these micro-droplets are formed only if there is sufficient shear force between the liquid metal and a continuous fluid phase. In the past, they used several different methods such as pressure fluctuations and changes in continuous phase flow rate to control the shear force and produced polymer, gas, etc. micro-droplets.In this research, use the electric potential to control...
An experimental review on microbubble generation to be used in echo-particle image velocimetry method to determine the pipe flow velocity
, Article Journal of Fluids Engineering, Transactions of the ASME ; Volume 135, Issue 3 , Feb , 2013 , Paper No: FE-12-1217 ; 00982202 (ISSN) ; Shafii, M. B ; Shirani, S ; Sharif University of Technology
2013
Abstract
Microbubbles are broadly used as ultrasound contrast agents. In this paper we use a low-cost flow focusing microchannel fabrication method for preparing microbubble contrast agents by using some surface active agents and a viscosity enhancing material to obtain appropriate microbubbles with desired lifetime and stability for any in vitro infusion for velocity measurement. All the five parameters that govern the bubble size extract and some efforts are done to achieve the smallest bubbles by adding suitable surfactant concentrations. By using these microbubbles for the echo-particle image velocimetry method, we experimentally determine the velocity field of steady state and pulsatile pipe...
An interface–particle interaction approach for evaluation of the co-encapsulation efficiency of cells in a flow-focusing droplet generator
, Article Sensors (Switzerland) ; Volume 20, Issue 13 , 2020 , Pages 1-17 ; Saidi, M. S ; Ghadami, S ; Kashaninejad, N ; Sharif University of Technology
MDPI AG
2020
Abstract
Droplet-based microfluidics offers significant advantages, such as high throughput and scalability, making platforms based on this technology ideal candidates for point-of-care (POC) testing and clinical diagnosis. However, the efficiency of co-encapsulation in droplets is suboptimal, limiting the applicability of such platforms for the biosensing applications. The homogeneity of the bioanalytes in the droplets is an unsolved problem. While there is extensive literature on the experimental setups and active methods used to increase the efficiency of such platforms, passive techniques have received less attention, and their fundamentals have not been fully explored. Here, we develop a novel...
Investigating the effects of precursor concentration and gelling parameters on droplet-based generation of Ca-Alginate microgels: identifying new stable modes of droplet formation
, Article Materials Today Chemistry ; Volume 24 , 2022 ; 24685194 (ISSN) ; Rezaeian, M ; Mahmoudi, Z ; Shamloo, A ; Kazemzadeh Hannani, S ; Sharif University of Technology
Elsevier Ltd
2022
Abstract
Droplet-based microfluidics is an attractive approach for producing microgels due to its high potential to control the size and shape of the particles and precisely entrap the substances within the hydrogel matrix. However, the microfluidic generation of monodisperse microgels with desired structures is still challenging. Indeed, the rheological and interfacial properties of the immiscible fluids, as well as the adopted gelling strategy, play important roles in microfluidic methods. Herein, sodium alginate droplets with different concentrations are generated via a microfluidic device with a flow-focusing unit. Besides, a combined in situ and ex situ strategy is optimized to crosslink sodium...