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    Curcumin as a green fluorescent label to revive the fluorescence property of functionalized graphene oxide nanosheets

    , Article Journal of Drug Delivery Science and Technology ; Volume 45 , June , 2018 , Pages 422-427 ; 17732247 (ISSN) Akbari, E ; Akhavan, O ; Hatamie, S ; Rahighi, R ; Sharif University of Technology
    Editions de Sante  2018
    Abstract
    In this work, graphene oxide (GO) aqueous suspensions prepared by a chemical exfoliation method showed a fluorescence peak at ∼615 nm. Photoluminescence spectroscopy determined that functionalization of the GO sheets by 3-(2-Aminoethylamino) propyltrimethoxysilane molecules significantly quench the fluorescence property of the GO sheets. Fourier transform infrared spectroscopy confirmed proper functionalization of the GO sheets. Curcumin was applied as a fluorescent natural material with an emission peak at ∼550 nm wavelength for green fluorescent labeling of the functionalized-GO sheets. The curcumin-labeled functionalized-GO sheets showed an intense emission band fluorescent property with... 

    Simple and rapid detection of L-dopa based on in situ formation of polylevodopa nanoparticles

    , Article Sensors and Actuators, B: Chemical ; Volume 243 , 2017 , Pages 715-720 ; 09254005 (ISSN) Hormozi Nezhad, M. R ; Moslehipour, A ; Bigdeli, A ; Sharif University of Technology
    Elsevier B.V  2017
    Abstract
    Levodopa [L-3, 4-dihydroxyphenylalanine, or L-DOPA] is an important neurotransmitter used for the treatment of neural disorders such as Parkinson's disease. Abnormal L-Dopa concentrations in biological fluids can be used for the evaluation of such diseases. In this work, a rapid and sensitive method for L-DOPA detection has been reported which is based on in situ formation of polylevodopa nanoparticles. Under alkaline conditions, L-DOPA is spontaneously oxidized to its quinone derivative and shows fluorescence properties. The fluorescence signal of the oxidation product has been monitored and used for the determination of L-DOPA in the presence of dopamine, uric acid, ascorbic acid and other...