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fluorouracil
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A correlative model to predict in vivo AUC for nanosystem drug delivery with release rate-limited absorption
, Article Journal of Pharmacy and Pharmaceutical Sciences ; Volume 15, Issue 4 , 2012 , Pages 583-591 ; 14821826 (ISSN) ; Mohammadi, K ; Mohammadi, G ; Valizadeh, H ; Barzegar Jalali, A ; Adibkia, K ; Nokhodchi, A ; Sharif University of Technology
2012
Abstract
Purpose. Drug release from nanosystems at the sites of either absorption or effect biophase is a major determinant of its biological action. Thus, in vitro drug release is of paramount importance in gaining insight for the systems performance in vivo. Methods. A novel in vitro in vivo correlation, IVIVC, model denoted as double reciprocal area method was presented and applied to 19 drugs from 55 nano formulations with total 336 data, gathered from literature. Results. The proposed model correlated the in vitro with in vivo parameters with overall error of 12.4 ± 3.9%. Also the trained version of the model predicted the test formulations with overall error of 15.8 ± 3.7% indicating the...
Graphene oxide-l-arginine nanogel: A pH-sensitive fluorouracil nanocarrier
, Article Biotechnology and Applied Biochemistry ; Volume 66, Issue 5 , 2019 , Pages 772-780 ; 08854513 (ISSN) ; Ghaemi, A ; Masoudi, G ; Chogan, F ; Rashedi, H ; Yazdian, F ; Omidi, M ; Javadi, S ; Haghiralsadat, B. F ; Teimouri, M ; Faal Hamedani, N ; Sharif University of Technology
Wiley-Blackwell Publishing Ltd
2019
Abstract
Nowadays, putting forward an accurate cancer therapy method with minimal side effects is an important topic of research. Nanostructures, for their ability in controlled and targeted drug release on specific cells, are critical materials in this field. In this study, a pH-sensitive graphene oxide-l-arginine nanogel was synthesized to carry and release 5-fluorouracil. Optimized conditions using statistical analysis, based on the maximum relative viscosity of nanogel, were evaluated: 5.489 for the concentration of l-arginine and 2.404 for pH. The prepared nanogels were characterized using scanning electron microscope and transmission electron microscope images and Fourier-transform infrared...
Burgeoning polymer nano blends for improved controlled drug release: A review
, Article International Journal of Nanomedicine ; Volume 15 , March , 2020 , Pages 4363-4392 ; Shahraki, B. T ; Rabiee, N ; Fatahi, Y ; Dinarvand, R ; Tavakolizadeh, M ; Ahmadi, S ; Rabiee, M ; Bagherzadeh, M ; Pourjavadi, A ; Farhadnejad, H ; Tahriri, M ; Webster, T. J ; Tayebi, L ; Sharif University of Technology
Dove Medical Press Ltd
2020
Abstract
With continual rapid developments in the biomedical field and understanding of the important mechanisms and pharmacokinetics of biological molecules, controlled drug delivery systems (CDDSs) have been at the forefront over conventional drug delivery systems. Over the past several years, scientists have placed boundless energy and time into exploiting a wide variety of excipients, particularly diverse polymers, both natural and synthetic. More recently, the development of nano polymer blends has achieved noteworthy attention due to their amazing properties, such as biocompatibility, biodegradability and more importantly, their pivotal role in controlled and sustained drug release in vitro and...
Simultaneous controlled release of 5-FU, DOX and PTX from chitosan/PLA/5-FU/g-C3N4-DOX/g-C3N4-PTX triaxial nanofibers for breast cancer treatment in vitro
, Article Colloids and Surfaces B: Biointerfaces ; Volume 179 , 2019 , Pages 495-504 ; 09277765 (ISSN) ; Hosseini, S ; Mahboobnia, K ; Boloursaz, L. A ; Moradi, M ; Irani, M ; Sharif University of Technology
Elsevier B.V
2019
Abstract
In the present study, the tri-layer nanofibers were synthesized via triaxial electrospinning process to control the sustained delivery of Doxorubicin (DOX), Paclitaxel (PTX) and 5- fluorouracil (5-FU) anticancer drugs from nanofibers. The 5-FU molecules were incorporated into the core solution (chitosan/polyvinyl alcohol (CS/PVA)) to fabricate the CS/PVA/5-FU inner layer of nanofibers. The intermediate layer was prepared from poly(lactic acid)/chitosan (PLA/CS) nanofibers. The DOX and PTX molecules were initially loaded into the g-C3N4 nanosheets and following were incorporated into the PLA/CS solution to fabricate the outer layer of nanofibers. The synthesized nanosheets and nanofibers were...
Brain-on-a-chip: Recent advances in design and techniques for microfluidic models of the brain in health and disease
, Article Biomaterials ; Volume 285 , 2022 ; 01429612 (ISSN) ; Shamloo, A ; Nasiri, R ; de Barros, N. R ; Wang, Z. Z ; Unluturk, B. D ; Libanori, A ; Ievglevskyi, O ; Diltemiz, S. E ; Sances, S ; Balasingham, I ; Seidlits, S. K ; Ashammakhi, N ; Sharif University of Technology
Elsevier Ltd
2022
Abstract
Recent advances in biomaterials, microfabrication, microfluidics, and cell biology have led to the development of organ-on-a-chip devices that can reproduce key functions of various organs. Such platforms promise to provide novel insights into various physiological events, including mechanisms of disease, and evaluate the effects of external interventions, such as drug administration. The neuroscience field is expected to benefit greatly from these innovative tools. Conventional ex vivo studies of the nervous system have been limited by the inability of cell culture to adequately mimic in vivo physiology. While animal models can be used, their relevance to human physiology is uncertain and...