Sharif Digital Repository

Most natural folate derivatives are highly sensitive to temperature, oxygen and light and their stability depends on food process condition. Alginate and pectin were evaluated for folic acid encapsulation and increasing its stability. By combining them and optimising encapsulation condition the efficiency was enhanced up to 90% . Furthermore, using polymers in combined form caused decrease in folic acid leakage from capsules in acidic condition of stomach. First of all, the time of encapsulation was measured which was 140-180 minutes. In this study the effect of Calcium Chloride concentration on encapsulation was studied. Therefore, two variables were selected which were pectin to algine... 

Folic acid is a pterin derivative containing a glutamyl moiety and essential for biological reactions. Pterins are a class of heterocyclic compounds with unique structures and biological functions. Tetrahydrobiopterine has been known to be essential for catalytic hydroxylation of aromatic amino acids by metal ions-containing aromatic amino acid hydroxylases. Metal ions at the active site of these enzymes have been inferred to be closely associated with the pterin cofactors in the catalytic reactions.Information on pterin-metal interaction may give clues to the role of metal ions in enzymatic reactions. With these points in mind, studies have been conducted to verify the formation of ternary... 

The complexation between folic acid and the complexes of Cu(L)2 (L = Glycine, Alanine, Valine) were investigated using UV.Vis spectroscopy. The values of the equilibrium constant K and molar absorption coefficient Ɛ of the complexes were estimated in the aquation environment at various temperatures. The temperature dependence of the K can be used for the determination of the thermodynamic reaction quantities (∆G, ∆H, ∆S) for linear regression fits to the Van’t Hoff equation. The kinetic studies reveals that the stoichiometry of reaction were 1:1 for these systems. All reaction were endothermic and the values of the ∆H are positive. In all cases entropy increased and the values of the ∆S... 

Application of nanoparticles in targeted delivery and controlled drug release is recently highly attracted especially in cancer therapy. In this study with the aim of developing a novel drug vector based on metallic nanoparticles, gold nanoparticles with their unique characteristics were used to design a vector for targeted anti-cancer drug delivery to tumor. First, gold nanoparticles were chemically synthesized therough sodium citrate and sodium brohydrate reductions with average diameters of 22 and 11 nm, respectively. Then, the activated poly ethylene glycol (PEG) and activated folic acid were conjugated to the lysine-capped gold nanoparticles. Subsequently, the widely used anticancer... 

This study aimed to prepare a type of microcapsule that microencapsulates folic acid and iron at the same time and protects these two substances against environmental and gastrointestinal conditions. Simultaneous release of these two nutrients has dual health properties and improves the efficiency of folic acid microencapsulation. In this study, biocomposites were formed containing alginate, pectin, and carboxymethylcellulose, and the microcapsules were synthesized by the ionization of calcium-alginate ions. Biocomposite optimization mixture with 13 experiments using experimental design software, optimal combination design method based on repopulation separator, restoring folic acid...