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gallic-acids
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Design and Fabrication of Drug-loaded Nanoparticles to Prevent Fibrillation of Alpha-synuclein in Parkinson
, M.Sc. Thesis Sharif University of Technology ; Mashayekhan, Shohreh (Supervisor) ; Morshedi, Dina (Supervisor)
Abstract
The purpose of this study is to assess the inhibitory effects of an appropriate nanoparticles loaded with gallic acid on the fibrillation of alpha-synuclein. Alpha-synuclein is a major component of protein plaques in synucleinopathies, particularly Parkinson’s disease. Gallic acid (GA, 3,4,5-trihydroxy benzoic acid) is a well–known small molecule which can inhibit the formation of α-synuclein fibrils. For the process of fibrillation, purified protein was incubated at 37◦C and pH 7.2. Fibrillation was analyzed by the standard fibril methods.after that investigated fabricating of gallic acid trapped in the chitosan nanoparticles and gallic acid loaded in chitosan –coated mesoporous silica...
Construction of a modified carbon paste electrode based on TiO2 nanoparticles for the determination of gallic acid
, Article Journal of Solid State Electrochemistry ; Volume 17, Issue 1 , 2013 , Pages 157-165 ; 14328488 (ISSN) ; Nami Ana, S. F ; Hashemnia, S ; Hormozi Nezhad, M. R ; Sharif University of Technology
2013
Abstract
A modified carbon paste electrode was prepared by incorporating the TiO2 nanoparticles in the carbon paste matrix. The electrochemical behavior of gallic acid (GA) is investigated on the surface of the electrode using cyclic voltammetry and differential pulse voltammetry. The surface morphology of the prepared electrode was characterized using the scanning electron microscopy. The results indicate that the electrochemical response of GA is improved significantly at the modified electrode compared with the unmodified electrode. Furthermore, the capabilities of electron transfer on these two electrodes were also investigated by electrochemical impedance spectroscopy. Under the optimized...
Determination of antioxidant component and activity of rice bran extract
, Article Scientia Iranica ; Volume 18, Issue 6 , December , 2011 , Pages 1402-1406 ; 10263098 (ISSN) ; Alemzadeh, I ; Maghsoudi, V ; Sharif University of Technology
2011
Abstract
Rice bran is one of the most important co-products in the rice milling. In this research, antioxidant activity of two Iranian rice bran varieties, Fajr and Tarem, extracted by three different solvents (methanol, ethanol and ethyl acetate) was evaluated. The order of antioxidant activity was evaluated by measurement of total phenolic content, antioxidant activity in linoleic acid system, reducing power and scavenging capacity by DPPH radical. The methanolic extract of Fajr rice bran showed a total phenolic content of 3.31 mg Gallic acid/gr rice bran and a DPPH free radical-scavenging activity of 93.91%, achieved at 50 mg/ml concentration, and a percent inhibition of linoleic acid peroxidation...
Quantitative structure - Mobility relationship study of a diverse set of organic acids using classification and regression trees and adaptive neuro-fuzzy inference systems
, Article Electrophoresis ; Volume 29, Issue 2 , 2008 , Pages 363-374 ; 01730835 (ISSN) ; Shahbazikhah, P ; Sharif University of Technology
2008
Abstract
A quantitative structure-mobility relationship was developed to accurately predict the electrophoretic mobility of organic acids. The absolute electrophoretic mobilities (μ0) of a diverse dataset consisting of 115 carboxylic and sulfonic acids were investigated. A set of 1195 zero- to three-dimensional descriptors representing various structural characteristics was calculated for each molecule in the dataset. Classification and regression trees were successfully used as a descriptor selection method. Four descriptors were selected and used as inputs for adaptive neuro-fuzzy inference system. The root mean square errors for the calibration and prediction sets are 1.61 and 2.27, respectively,...