Loading...
Search for:
gelation-time
0.005 seconds
Gelation time and degradation rate of chitosan-based injectable hydrogel
, Article Journal of Sol-Gel Science and Technology ; Volume 42, Issue 1 , 2007 , Pages 47-53 ; 09280707 (ISSN) ; Abdekhodaie, M. J ; Ramazani S. A., A ; Sharif University of Technology
2007
Abstract
Gelation time and degradation rate of thermally-sensitive aqueous solutions of chitosan/Gp (glycerophosphate disodium salt) have been studied. The effects of different parameters such as Gp salt concentration, solution temperature, degree of deacetylation of chitosan (DDA) and drug loading on the gelation time have been investigated. Gravimetric analysis, gel permeation chromatography and FTIR spectrophotometry were used to investigate the influence of the DDA and concentration of chitosan solution on hydrogel degradation. The presented results indicated that gelation time decreases by increasing Gp salt concentration, temperature, concentration and DDA of chitosan solutions, while drug...
A dual functional chondro-inductive chitosan thermogel with high shear modulus and sustained drug release for cartilage tissue engineering
, Article International Journal of Biological Macromolecules ; Volume 205 , 2022 , Pages 638-650 ; 01418130 (ISSN) ; Mehrjou, B ; Wang, D ; Bagheri, R ; Solouk, A ; Chu, P. K ; Wu, H ; Sharif University of Technology
Elsevier B.V
2022
Abstract
We report a chitosan-based nanocomposite thermogel with superior shear modulus resembling that of cartilage and dual pro-chondrogenic and anti-inflammatory functions. Two therapeutic agents, kartogenin (KGN) and diclofenac sodium (DS), are employed to promote chondrogenesis of stem cells and suppress inflammation, respectively. To extend the release time in a controlled manner, KGN is encapsulated in the uniform-sized starch microspheres and DS is loaded into the halloysite nanotubes. Both drug carriers are doped into the maleimide-modified chitosan hydrogel to produce a shear modulus of 167 ± 5 kPa that is comparable to that of articular cartilage (50–250 kPa). Owing to the hydrogel...